TP-020
Based on 1 Customer Validation
TP-020 (MGAT2-IN-1), a chemical probe, is an orally active inhibitor of monoacylglycerol acyltransferase (MGAT2) with IC50 of 7.8 and 2.4 nM for human and mouse MGAT2, respectively.
For research use only. We do not sell to patients.
- Purity : 99.94%
- CAS No.: 1800025-30-2
- Formula: C27H21ClF5N7O3S
- Molecular Weight:654.01
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 2 years , -20°C, 1 year
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Protocols
- Purity & Documentation
- References
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Help & FAQs
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TP-020 (Standard)Reference Standard
Biological Activity
Description
IC50 & Target
IC50: 7.8 nM (Human MGAT2), 2.4 nM (Mouse MGAT2)[1]
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 1800025-30-2
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Appearance Solid
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Molecular Weight 654.01
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Formula C27H21ClF5N7O3S
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Color White to gray
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SMILES
O=S(C1=CC2=C(N(C3=NC=C(C4=CC(C(F)(F)F)=NN4C)C=N3)CC2)C(N5C(CCC5)=O)=C1)(NC6=C(F)C=C(Cl)C=C6F)=O
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Synonyms
MGAT2-IN-1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 2 years -20°C 1 year
Solvent & Solubility
In Vitro:
DMSO : ≥ 125 mg/mL (191.13 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Protocols
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Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.
Purity & Documentation
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Data Sheet (277 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.5290 mL | 7.6451 mL | 15.2903 mL | 38.2257 mL |
| 5 mM | 0.3058 mL | 1.5290 mL | 3.0581 mL | 7.6451 mL | |
| 10 mM | 0.1529 mL | 0.7645 mL | 1.5290 mL | 3.8226 mL | |
| 15 mM | 0.1019 mL | 0.5097 mL | 1.0194 mL | 2.5484 mL | |
| 20 mM | 0.0765 mL | 0.3823 mL | 0.7645 mL | 1.9113 mL | |
| 25 mM | 0.0612 mL | 0.3058 mL | 0.6116 mL | 1.5290 mL | |
| 30 mM | 0.0510 mL | 0.2548 mL | 0.5097 mL | 1.2742 mL | |
| 40 mM | 0.0382 mL | 0.1911 mL | 0.3823 mL | 0.9556 mL | |
| 50 mM | 0.0306 mL | 0.1529 mL | 0.3058 mL | 0.7645 mL | |
| 60 mM | 0.0255 mL | 0.1274 mL | 0.2548 mL | 0.6371 mL | |
| 80 mM | 0.0191 mL | 0.0956 mL | 0.1911 mL | 0.4778 mL | |
| 100 mM | 0.0153 mL | 0.0765 mL | 0.1529 mL | 0.3823 mL |
TP-020 Related Classifications
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