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Cat. No.: HY-162557

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VEGFR-2-IN-45

VEGFR-2-IN-45 (compound 3j) is a potent inhibitor of VEGFR-2, with the IC₅₀ of 0.2 μM. VEGFR-2-IN-45 plays an important role in cancer research.

For research use only. We do not sell to patients.

CAS No.: 3042018-08-3
Formula: C₂₈H₂₃ClN₆O₃S
Molecular Weight:559.04

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (269 KB)

VEGFR-2-IN-45 Chemical Structure

CAS No.: 3042018-08-3

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- Cellular Effect
Chemical Information
Protocols (1)
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
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Biological Activity

Description

VEGFR-2-IN-45 (compound 3j) is a potent inhibitor of VEGFR-2, with the IC₅₀ of 0.2 μM. VEGFR-2-IN-45 plays an important role in cancer research^[1].

IC₅₀ & Target

VEGFR-2

0.2 μM (IC₅₀)

All VEGFR Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
A549	IC₅₀	7.66 μM Compound: 3j	Cytotoxicity against human A549 cells incubated for 72 hrs by MTT assay Cytotoxicity against human A549 cells incubated for 72 hrs by MTT assay	[PMID: 38894896]
HUVEC	IC₅₀	178.7 μM Compound: 3j	Cytotoxicity against HUVECs incubated for 72 hrs by MTT assay Cytotoxicity against HUVECs incubated for 72 hrs by MTT assay	[PMID: 38894896]
MCF7	IC₅₀	5.86 μM Compound: 3j	Cytotoxicity against human MCF7 cells incubated for 72 hrs by MTT assay Cytotoxicity against human MCF7 cells incubated for 72 hrs by MTT assay	[PMID: 38894896]
WI-38	IC₅₀	21.63 μM Compound: 3j	Cytotoxicity against human WI-38 cells incubated for 72 hrs by MTT assay Cytotoxicity against human WI-38 cells incubated for 72 hrs by MTT assay	[PMID: 38894896]

Chemical Information

CAS No. 3042018-08-3
Molecular Weight 559.04
Formula C₂₈H₂₃ClN₆O₃S
SMILES

O=C(N1C2=CC=C(S(=O)(NC3=NC=CC=N3)=O)C=C2)/C(N=C1C4=CC=C(Cl)C=C4)=C/C5=CC=C(N(C)C)C=C5
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Protocols

All Cell Biology

Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (269 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Manar R, et al. Insight on Some Newly Synthesized Trisubstituted Imidazolinones as VEGFR-2 Inhibitors. ACS Med. Chem. Lett. MAY 20, 2024.

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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