WIZ degrader 7
WIZ degrader 7 (Example 16) is a WIZ molecular glue degrader with an IC50 value of < 0.01 μM. WIZ degrader 7 can be used to investigate sickle cell disease (SCD) and thalassemia.
For research use only. We do not sell to patients.
- CAS No.: 3036553-83-7
- Formula: C29H24N6O4
- Molecular Weight:520.54
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Protocols
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
In Vitro
Sickle cell disease (SCD) is a group of serious inherited blood disorders that cause red blood cells to twist and deform into a sickle shape. These cells can cause blood flow obstruction, leading to severe pain, organ damage, and premature death. β-thalassemia is a group of inherited blood disorders caused by reduced or absent synthesis of β-globin, resulting in anemia. WIZ is widely expressed and plays a role in targeting G9a/GLP histone methyltransferases to genomic sites to regulate chromatin structure and transcription.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.
Chemical Information
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CAS No. 3036553-83-7
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Molecular Weight 520.54
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Formula C29H24N6O4
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SMILES
O=C1C2=C(C(N1C3C(NC(CC3)=O)=O)=O)C(NC4=CC5=C(C=C4C6=CC(C)=NC=C6)N=CN5C7CC7)=CC=C2
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Protocols
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Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
WIZ degrader 7 Related Classifications
HY-163824 Related Classifications
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