Zinilisib
Zinilisib (Zinilisibum) is a PI3K inhibitor. Zinilisib potently inhibits the phosphorylation of AKT in cells expressing mutant PI3KαH1047R and wild-type PI3Kα, with IC50 values of 1-500 nM and 2-15 μM, respectively. Zinilisib can be used in breast cancer-related research.
For research use only. We do not sell to patients.
- CAS No.: 3031974-57-6
- Formula: C26H29F3N4O3
- Molecular Weight:502.53
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
In Vitro
Zinilisib (Example 8) potently inhibits the proliferation of T47D cells expressing mutant PI3KαH1047R, with a mean EC50 ranging from 1 nM to 500 nM; it also inhibits the proliferation of SKBR3 cells expressing wild-type PI3Kα, with a mean EC50 ranging from 2 μM to 15 μM[2].
Zinilisib (6 h) potently inhibits AKT phosphorylation in T47D cells expressing mutant PI3KαH1047R, with a mean IC50 ranging from 1 nM to 500 nM; it also inhibits AKT phosphorylation in SKBR3 cells expressing wild-type PI3Kα, with a mean IC50 ranging from 2 μM to 15 μM[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:T47D cells expressing mutant PI3Kα (H1047R), SKBR3 cells expressing wild-type PI3Kα
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Concentration:10-point dilution series
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Incubation Time:72 h
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Result:Inhibited proliferation of T47D cells with an average EC50 in the range of 1 nM to 500 nM.
Inhibited proliferation of SKBR3 cells with an average EC50 in the range of 2 μM to 15 μM.
Chemical Information
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CAS No. 3031974-57-6
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Molecular Weight 502.53
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Formula C26H29F3N4O3
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SMILES
OC(C(C=CC=C1)=C1N[C@@H](C2=C3C(C(N(C(N4CCN(CC4)CC(F)(F)F)=C3)C)=O)=CC(C)=C2)C)=O
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Synonyms
zinilisibum
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Zinilisib Related Classifications
HY-184099 Related Classifications
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