β-Amyloid (22-35) TFA
Based on 1 Customer Validation
β-Amyloid 22-35 (Amyloid β-Protein 22-35) TFA, the residues 22-35 fragment ofβ-amyloid protein, has a cytotoxic effect on cultured neurons from the rat hippocampus in serum-free medium. β-Amyloid 22-35 TFA forms aggregates and typical amyloid fibrils resembling those of the β-amyloid protein in neutral buffer solution).
For research use only. We do not sell to patients.
- Purity: 95.24%
- Formula: C61H103F3N16O23S
- Molecular Weight:1517.64
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Storage:
Sealed storage, away from moisture.
Powder -80°C, 2 years , -20°C, 1 year* The compound is unstable in solutions, freshly prepared is recommended.
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
β-Amyloid 22-35 (Amyloid β-Protein 22-35) TFA shows significant cytotoxicity on the rat hippocampal neurons at 40 μg/mL, but exhibits no cytotoxic effect on the glial cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Glu-Asp-Val-Gly-Ser-Asn-Lys-Gly-Ala-Ile-Ile-Gly-Leu-Met
EDVGSNKGAIIGLM
Chemical Information
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Appearance Solid
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Molecular Weight 1517.64
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Formula C61H103F3N16O23S
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Color White to off-white
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Synonyms
Amyloid β-Protein (22-35) TFA
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Sealed storage, away from moisture
Powder -80°C 2 years -20°C 1 year * The compound is unstable in solutions, freshly prepared is recommended.
Solvent & Solubility
H2O : 100 mg/mL (65.89 mM; Need ultrasonic)
Please refer to the solubility information to select the appropriate solvent. The compound is unstable in solutions, freshly prepared is recommended.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. The compound is unstable in solutions, freshly prepared is recommended.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Working solution concentration: 0.22 mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
Purity & Documentation
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Data Sheet (270 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
[1]. Takadera T, et al. Toxic effect of a beta-amyloid peptide (beta 22-35) on the hippocampal neuron and its prevention. Neurosci Lett. 1993;161(1):41‐44. [Content Brief]
[2]. Zhou WW, et al. Decreasing oxidative stress and neuroinflammation with a multifunctional peptide rescues memory deficits in mice with Alzheimer disease. Free Radic Biol Med. 2014;74:50-63. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. The compound is unstable in solutions, freshly prepared is recommended.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O | 1 mM | 0.6589 mL | 3.2946 mL | 6.5892 mL | 16.4729 mL |
| 5 mM | 0.1318 mL | 0.6589 mL | 1.3178 mL | 3.2946 mL | |
| 10 mM | 0.0659 mL | 0.3295 mL | 0.6589 mL | 1.6473 mL | |
| 15 mM | 0.0439 mL | 0.2196 mL | 0.4393 mL | 1.0982 mL | |
| 20 mM | 0.0329 mL | 0.1647 mL | 0.3295 mL | 0.8236 mL | |
| 25 mM | 0.0264 mL | 0.1318 mL | 0.2636 mL | 0.6589 mL | |
| 30 mM | 0.0220 mL | 0.1098 mL | 0.2196 mL | 0.5491 mL | |
| 40 mM | 0.0165 mL | 0.0824 mL | 0.1647 mL | 0.4118 mL | |
| 50 mM | 0.0132 mL | 0.0659 mL | 0.1318 mL | 0.3295 mL | |
| 60 mM | 0.0110 mL | 0.0549 mL | 0.1098 mL | 0.2745 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
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