β-catenin-IN-9 

β-catenin-IN-9 is a β-catenin inhibitor. β-catenin-IN-9 induces apoptosis, cell cycle arrest, and inhibits migration, invasion, and epithelial-mesenchymal transition (EMT) in colorectal cancer cells. β-catenin-IN-9 suppresses the transcription of β-catenin and vimentin, and significantly inhibits β-catenin at the protein level. β-catenin-IN-9 can be used for the research of colorectal cancer^[1].

β-catenin-IN-9 (compound 10d) demonstrates potent cytotoxic activity against Colo-205 cells, with an IC₅₀ value of 0.55 μM^[1].
β-catenin-IN-9 (0.55 μM; 48 hours; Colo-205) demonstrates potent cytotoxic activity, induces apoptosis, and inhibits migration and invasion, induces cell cycle arrest in colorectal cancer cells, leading to increased total cell death and S-phase cell accumulation^[1].
β-catenin-IN-9 (0.55 μM; 48 hours; Colo-205) significantly inhibits β-catenin protein levels and increases vimentin protein levels^[1].
β-catenin-IN-9 (0.55 μM; 48 hours; Colo-205) significantly suppresses gene expression of β-catenin and vimentin, and induces E-cadherin expression^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

670.99

C₄₀H₅₈N₆OS

3029462-00-5

CCCCCCCCCCCCCCCCCC1=NN=C(SCN2CCOCC2)N1/N=C/C3=CN(CC4=CC=CC=C4)C5=C3C=CC=C5

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Abdelmegeed H, et al. A novel 1,2,4-triazole derivative inhibits epithelial-mesenchymal transition in metastatic colorectal cancer via β-catenin suppression. Eur J Med Chem. 2026;302(Pt 1):118279.  [Content Brief]