β-catenin-IN-9
β-catenin-IN-9 is a β-catenin inhibitor. β-catenin-IN-9 induces apoptosis, cell cycle arrest, and inhibits migration, invasion, and epithelial-mesenchymal transition (EMT) in colorectal cancer cells. β-catenin-IN-9 suppresses the transcription of β-catenin and vimentin, and significantly inhibits β-catenin at the protein level. β-catenin-IN-9 can be used for the research of colorectal cancer.
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- No. CAS: 3029462-00-5
- Fòrmula: C40H58N6OS
- Peso molecular:670.99
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Almacenamiento:
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Actividad biológica
Descripciòn
In Vitro
β-catenin-IN-9 (compound 10d) demonstrates potent cytotoxic activity against Colo-205 cells, with an IC50 value of 0.55 μM[1].
β-catenin-IN-9 (0.55 μM; 48 hours; Colo-205) demonstrates potent cytotoxic activity, induces apoptosis, and inhibits migration and invasion, induces cell cycle arrest in colorectal cancer cells, leading to increased total cell death and S-phase cell accumulation[1].
β-catenin-IN-9 (0.55 μM; 48 hours; Colo-205) significantly inhibits β-catenin protein levels and increases vimentin protein levels[1].
β-catenin-IN-9 (0.55 μM; 48 hours; Colo-205) significantly suppresses gene expression of β-catenin and vimentin, and induces E-cadherin expression[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:Colo-205
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Concentration:0.55 μM
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Incubation Time:48 hours
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Result:Significantly decreased the percentage of migrated cells by 50% and the percentage of invasive cells by 66%, indicating that it not only inhibits cell proliferation but also suppresses the migration and invasion capabilities of colorectal cancer cells.
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Cell Line:Colo-205
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Concentration:0.55 μM
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Incubation Time:48 hours
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Result:Significantly inhibited the protein levels of β-catenin without affecting the protein levels of E-cadherin. The protein level of vimentin increased, which contrasts with its effect on vimentin mRNA level, indicating post-translational regulation.
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Cell Line:Colo-205
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Concentration:0.55 μM
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Incubation Time:48 hours
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Result:Significantly suppressed the transcription of β-catenin and vimentin, while inducing the expression of E-cadherin, suggesting that it inhibits the epithelial-mesenchymal transition (EMT) in colorectal cancer cells.
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Cell Line:Colo-205
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Concentration:0.55 μM
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Incubation Time:48 hours
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Result:The late apoptosis was significantly up-regulated 14.8-fold, while necrosis significantly showed a 16-fold increase.
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Cell Line:Colo-205
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Concentration:0.55 μM
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Incubation Time:48 hours
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Result:Led to cell cycle arrest at S-phase in colorectal cancer cells.
Chemical Information
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No. CAS 3029462-00-5
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Peso molecular 670.99
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Fòrmula C40H58N6OS
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SMILES
CCCCCCCCCCCCCCCCCC1=NN=C(SCN2CCOCC2)N1/N=C/C3=CN(CC4=CC=CC=C4)C5=C3C=CC=C5
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
β-catenin-IN-9 Related Classifications
HY-179408 Related Classifications
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