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Cat. No.: HY-N6741R

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β-Zearalenol (Standard)

β-Zearalenol (Standard) is the analytical standard of β-Zearalenol (HY-N6741). This product is intended for research and analytical applications. β-Zearalenol is a zearalenone metabolite and Estrogen receptor binder (K_d = 0.406 nM) that induces apoptosis through activation of p53, JNK, and p38 kinases and the mitochondrial apoptosis pathway, while inhibiting CYP19A1 and inducing autophagy via SIRT1. β-Zearalenol is used in research on cardiotoxicity, mycotoxin-induced reproductive toxicity, and breast cancer.

For research use only. We do not sell to patients.

CAS No.: 71030-11-0
Formula: C₁₈H₂₄O₅
Molecular Weight:320.38

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

β-Zearalenol (Standard) Chemical Structure

CAS No.: 71030-11-0

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Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

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The compound is the grade of analytical standard, which is the reference standard supplied assay. It is commonly used in qualitative, quantitative and methodological research experiments in HPLC, GC and MS.

Chemical Information

CAS No. 71030-11-0
Molecular Weight 320.38
Formula C₁₈H₂₄O₅
SMILES

OC1=C2C(O[C@H](CCC[C@H](CCC/C=C/C2=CC(O)=C1)O)C)=O
Structure Classification
- Phenols
- Antibiotics
Initial Source
- Microorganisms
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

References

[1]. Lu J, et al. Cellular mechanisms of the cytotoxic effects of the zearalenone metabolites α-zearalenol and β-zearalenol on RAW264.7 macrophages. Toxicology in vitro : an international journal published in association with BIBRA. 2013 Apr;27(3):1007-17.

[2]. Ben Salem I, et al. SIRT1 protects cardiac cells against apoptosis induced by zearalenone or its metabolites α- and β-zearalenol through an autophagy-dependent pathway. Toxicology and applied pharmacology. 2017 Jan 01;314:82-90.

[3]. Yang F, et al. Melatonin alleviates β-zearalenol and HT-2 toxin-induced apoptosis and oxidative stress in bovine ovarian granulosa cells. Environmental toxicology and pharmacology. 2019 May;68:52-60. [Content Brief]

[4]. Othmen ZO, et al. Cytotoxicity effects induced by Zearalenone metabolites, alpha Zearalenol and beta Zearalenol, on cultured Vero cells. Toxicology. 2008 Oct 30;252(1-3):72-7.

[5]. Faisal Z, et al. Interactions of zearalenone and its reduced metabolites α-zearalenol and β-zearalenol with serum albumins: species differences, binding sites, and thermodynamics. Mycotoxin research. 2018 Nov;34(4):269-278.

[6]. Tiemann U, et al. Influence of the mycotoxins alpha- and beta-zearalenol and deoxynivalenol on the cell cycle of cultured porcine endometrial cells. Reproductive toxicology (Elmsford, N.Y.). 2003;17(2):209-18.

[7]. Zheng Z, et al. Species-specific inhibition of human and rat aromatase by mycotoxins: Integrated enzyme assays, docking, and structure-activity relationship analysis. International journal of biological macromolecules. 2025 Sep;322(Pt 1):146406.

[8]. Ben Salem I, et al. Activation of ER stress and apoptosis by α- and β-zearalenol in HCT116 cells, protective role of Quercetin. Neurotoxicology. 2016 Mar;53:334-342.

[9]. Abid-Essefi S, et al. Comparative study of toxic effects of zearalenone and its two major metabolites alpha-zearalenol and beta-zearalenol on cultured human Caco-2 cells. Journal of biochemical and molecular toxicology. 2009;23(4):233-43.

[10]. Tatay E, et al. Estrogenic activity of zearalenone, α-zearalenol and β-zearalenol assessed using the E-screen assay in MCF-7 cells. Toxicology mechanisms and methods. 2018 May;28(4):239-242. [Content Brief]

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How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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β-Zearalenol (Standard)

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