γ-Secretase modulator 13
γ-Secretase modulator 13 (compound 4) is a gamma-secretase modulator (GSMs) that inhibits the production of the aggregated amyloid β-peptide Aβ42 with an IC50 value of 163 nM. γ-Secretase modulator 13 can be used in the study of Alzheimer's disease.
For research use only. We do not sell to patients.
- CAS No.: 1353570-40-7
- Formula: C22H23FN6S
- Molecular Weight:422.52
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| SH-SY5Y | IC50 |
163 nM
Compound: 6
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Modulation of gamma-secretase in human SH-SY5Y cells overexpressing wild-type human APP751 assessed as inhibition of Abeta42 level after 24 hrs by ELISA
Modulation of gamma-secretase in human SH-SY5Y cells overexpressing wild-type human APP751 assessed as inhibition of Abeta42 level after 24 hrs by ELISA
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[PMID: 27426299] |
Chemical Information
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CAS No. 1353570-40-7
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Molecular Weight 422.52
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Formula C22H23FN6S
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SMILES
FC1=C(N2C=NC(C)=C2)C=CC(C3=CSC(NC4=C5C(CCCC5)=NN4CC)=N3)=C1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
γ-Secretase modulator 13 Related Classifications
HY-150049 Related Classifications
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