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Cat. No.: HY-P2699

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ω-Grammotoxin SIA

(Synonyms: GrTx; ω-GsTx SIA)

ω-Grammotoxin SIA (GrTx) is P/Q and N-type voltage-gated Calcium channels inhibitor. ω-Grammotoxin SIA is also a protein toxin that can be obtained from spider venom. ω-Grammotoxin SIA has the potential to study neurological diseases as well as cardiovascular diseases.

For research use only. We do not sell to patients.

CAS No.: 152617-90-8
Formula: C₁₇₇H₂₆₃N₅₃O₄₉S₆
Molecular Weight:4109.70

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

ω-Grammotoxin SIA Chemical Structure

CAS No.: 152617-90-8

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity

Description

All Calcium Channel Isoforms :

Chemical Information

CAS No. 152617-90-8
Molecular Weight 4109.70
Formula C₁₇₇H₂₆₃N₅₃O₄₉S₆
Synonyms

GrTx; ω-GsTx SIA
Sequence

Asp-Cys-Val-Arg-Phe-Trp-Gly-Lys-Cys-Ser-Gln-Thr-Ser-Asp-Cys-Cys-Pro-His-Leu-Ala-Cys-Lys-Ser-Lys-Trp-Pro-Arg-Asn-Ile-Cys-Val-Trp-Asp-Gly-Ser-Val-NH2 (Disulfide bridge:Cys2-Cys16;Cys9-Cys21;Cys15-Cys30)
Sequence Shortening

DCVRFWGKCSQTSDCCPHLACKSKWPRNICVWDGSV-NH2 (Disulfide bridge:Cys2-Cys16;Cys9-Cys21;Cys15-Cys30)
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (260 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Takeuchi K, et al. Solution structure of omega-grammotoxin SIA, a gating modifier of P/Q and N-type Ca(2+) channel. J Mol Biol. 2002 Aug 16;321(3):517-26. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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ω-Grammotoxin SIA

All Calcium Channel Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

ω-Grammotoxin SIA Related Classifications

HY-P2699 Related Classifications