1. Anti-infection
  2. Bacterial
  3. β-Glucuronidase-IN-1

β-Glucuronidase-IN-1 

Cat. No.: HY-103081
Handling Instructions

β-Glucuronidase-IN-1 is a potent, selective, uncompetitive, and orally active E. coli bacterial β-glucuronidase inhibitor, exhibiting an IC50 and a Ki of 283 nM and 164 nM, respectively.

For research use only. We do not sell to patients.

β-Glucuronidase-IN-1 Chemical Structure

β-Glucuronidase-IN-1 Chemical Structure

CAS No. : 484006-66-8

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Description

β-Glucuronidase-IN-1 is a potent, selective, uncompetitive, and orally active E. coli bacterial β-glucuronidase inhibitor, exhibiting an IC50 and a Ki of 283 nM and 164 nM, respectively[1].

IC50 & Target

IC50: 283 nM (E. coli β-glucuronidase)
Ki: 164 nM (E. coli β-glucuronidase)[1]

In Vitro

β-Glucuronidase-IN-1 (Inhibitor 1) (0.01-100 μM) inhibits E. coli β-glucuronidase activity as a dose-dependent manner and exhibits an IC50 and a Ki value with 283 nM and 164 nM, respectively[1].
β-Glucuronidase-IN-1 (100 μM; 24-72 hours) maintains potent efficacy in living bacterial cells (EC50=17.7 nM), it does not affect bacterial cell growth under aerobic or anaerobic conditions or killing mammalian epithelial cells[1].

Cell Viability Assay[1]

Cell Line: CMT93, CaCO-2, HCT116 cells
Concentration: 100 μM
Incubation Time: 24 hours, 48 hours and 72 hours
Result: Did not impact mammalian cell survival and any reduction in cell viability were attributed to the presence of DMSO.
In Vivo

β-Glucuronidase-IN-1 (oral gavage; 10 μg; twice per day; 11 days) protects the mouse GI epithelium from CPT-11–induced damage and protects the glandular structure of CPT-11-treated intestinal tissues[1].

Animal Model: Healthy 6- to 8-week-old Balb/cJ mice[1]
Dosage: 10 μg
Administration: Oral gavage; twice per day; 11 days
Result: Alleviated CPT-11-induced toxicity in mice.
Molecular Weight

425.54

Formula

C₂₃H₂₇N₃O₃S

CAS No.

484006-66-8

SMILES

S=C(NC1=CC=C(OCC)C=C1)N(CC2=CC3=C(NC2=O)C(C)=CC(C)=C3)CCO

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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Keywords:

β-Glucuronidase-IN-1BacterialColonepitheliumβ-glucuronidaseCMT93CaCO-2HCT116Inhibitorinhibitorinhibit

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β-Glucuronidase-IN-1
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