1-Caffeoylquinic acid
Based on 1 publication(s) in Google Scholar
1-Caffeoylquinic acid is an effective NF-κB inhibitor, shows significant binding affinity to the RH domain of p105 with Ki of 0.007 μM. 1-Caffeoylquinic acid has anti-oxidative stress ability. 1-Caffeoylquinic acid is the Inhibitor for PD-1/PD-L1.
For research use only. We do not sell to patients.
- Purity : 99.54%
- CAS No.: 1241-87-8
- Formula: C16H18O9
- Molecular Weight:354.31
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Storage:
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Protocols
- Purity & Documentation
- References
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Help & FAQs
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HY-N0787
Cryptochlorogenic acidphenolic Acid Compound -
HY-N0722
Neochlorogenic acidCOX Inhibitor -
HY-N0055
Chlorogenic acidAntioxidant -
HY-N0057
3,4-Dicaffeoylquinic acidAntioxidant -
HY-N0056
Isochlorogenic acid AAntioxidant -
HY-N0460R
1-Caffeoylquinic acid (Standard)NF-κB Inhibitor -
HY-N0510
Aristolochic acid ANF-κB Inhibitor -
HY-19991
BMS-1PD-1/PD-L1 PPI Inhibitor -
HY-N0387
RhynchophyllineNF-κB Inhibitor -
HY-N0436
EngeletinNF-κB Inhibitor -
HY-14621
ZingeronePhenolic Ketone -
HY-N0277
AconineNF-κB Inhibitor
Publications Citing Use of MedChemExpress (MCE) 1-Caffeoylquinic acid
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Biological Activity
Description
IC50 & Target
Ki: 0.007 μM (1-Caffeoylquinic acid)[1]
In Vitro
1-Caffeoylquinic acid blocks the interaction between PD-1 and PD-L1 (IC50=87.28 µM), restores the activity of T cells, and enhances anti-tumor immune response[3].
1-Caffeoylquinic acid is the main phenolic compound that can be isolated from Tetrastigma hemsleyanum leaf. T. hemsleyanum leaf extracts exhibits antioxidant and antiproliferative activities[4].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.
Chemical Information
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CAS No. 1241-87-8
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Appearance Solid
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Molecular Weight 354.31
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Formula C16H18O9
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Color White to off-white
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SMILES
O[C@@H]1[C@H](O)C[C@@](OC(/C=C/C2=CC(O)=C(O)C=C2)=O)(C(O)=O)C[C@H]1O
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Structure Classification
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Publications (1)
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Journal Impact Factor
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Most Recent
Solvent & Solubility
In Vitro:
DMSO : 250 mg/mL (705.60 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Protocols
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ROS/oxidative-stress fluorescent staining
ROS/oxidative-stress fluorescent staining uses cell-permeant fluorogenic probes that become fluorescent after oxidation inside cells or tissues; commonly used examples include DCFH-DA/DCFDA for broad cellular oxidant detection, DHE for superoxide-related signal detection, MitoSOX for mitochondrial superoxide-related signal detection, and CellROX probes for oxidative-stress-associated fluorescence readouts. The assay detects probe oxidation rather than a single ROS species unless the probe and analysis method have been chemically validated for that species. DCFH-DA enters cells, is deacetylated by intracellular esterases to DCFH, and produces fluorescent DCF after oxidation, so the readout is used as an operational measure of total cellular oxidative stress rather than a species-specific ROS measurement. DHE and MitoSOX can report superoxide-related oxidation, but red fluorescence alone can include non-specific ethidium-like oxidation products; HPLC or optimized spectral approaches are
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Research Protocol for Inflammation-related Diseases
The NLRP3 inflammasome is a cytosolic innate immune signaling platform that integrates priming signals and danger-signal activation to promote caspase-1 activation, maturation of IL-1β and IL-18, and gasdermin D-mediated pyroptotic cell death. The core experimental logic is to determine whether inflammatory disease phenotypes are driven by increased NLRP3 expression, ASC-containing inflammasome assembly, caspase-1 cleavage, GSDMD cleavage, and extracellular release of IL-1β/IL-18 rather than by nonspecific cell injury alone. The pathway is strongly linked to inflammation-related disease phenotypes because monosodium urate crystals activate NALP3/NLRP3 inflammasome signaling in gout-like crystal inflammation, cholesterol crystals activate NLRP3 inflammasomes in atherogenesis models, and DSS-induced intestinal inflammation has been reported to involve NLRP3 inflammasome activity. However, experimental colitis studies also show context-dependent protective effects of NLRP3 inflammasome co
Purity & Documentation
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Data Sheet (275 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
[1]. Khan MK, et al. Dietary phytochemicals as potent chemotherapeutic agents against breast cancer: Inhibition of NF-κB pathway via molecular interactions in rel homology domain of its precursor protein p105. Pharmacogn Mag. 2013 Jan;9(33):51-7. [Content Brief]
[2]. Jiang Y, et al. Caffeoylquinic acid derivatives rich extract from Gnaphalium pensylvanicum willd. Ameliorates hyperuricemia and acute gouty arthritis in animal model. BMC Complement Altern Med. 2017 Jun 17;17(1):320. [Content Brief]
[3]. Han Y, et al. PD-1/PD-L1 inhibitor screening of caffeoylquinic acid compounds using surface plasmon resonance spectroscopy. Anal Biochem. 2018 Apr 15;547:52-56. [Content Brief]
[4]. Sun Y, et al., Qualitative and quantitative analysis of phenolics in Tetrastigma hemsleyanum and their antioxidant and antiproliferative activities. J Agric Food Chem. 2013 Nov 6;61(44):10507-15. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.8224 mL | 14.1119 mL | 28.2239 mL | 70.5597 mL |
| 5 mM | 0.5645 mL | 2.8224 mL | 5.6448 mL | 14.1119 mL | |
| 10 mM | 0.2822 mL | 1.4112 mL | 2.8224 mL | 7.0560 mL | |
| 15 mM | 0.1882 mL | 0.9408 mL | 1.8816 mL | 4.7040 mL | |
| 20 mM | 0.1411 mL | 0.7056 mL | 1.4112 mL | 3.5280 mL | |
| 25 mM | 0.1129 mL | 0.5645 mL | 1.1290 mL | 2.8224 mL | |
| 30 mM | 0.0941 mL | 0.4704 mL | 0.9408 mL | 2.3520 mL | |
| 40 mM | 0.0706 mL | 0.3528 mL | 0.7056 mL | 1.7640 mL | |
| 50 mM | 0.0564 mL | 0.2822 mL | 0.5645 mL | 1.4112 mL | |
| 60 mM | 0.0470 mL | 0.2352 mL | 0.4704 mL | 1.1760 mL | |
| 80 mM | 0.0353 mL | 0.1764 mL | 0.3528 mL | 0.8820 mL | |
| 100 mM | 0.0282 mL | 0.1411 mL | 0.2822 mL | 0.7056 mL |
1-Caffeoylquinic acid Related Classifications
HY-N0460 Related Classifications
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