country

Change Language

EN - English
FR - Français
DE - Deutsch
ES - Español
JA - 日本語
KO - 한국어

Country or Region:

United States

Product Name	Size / Unit Price	Qty

Total: USD 0.00 Checkout

製品番号: HY-187125

Copy Link Print Information

11β-HSD1-IN-27

11β-HSD1-IN-27 is a human and mouse 11β-hydroxysteroid dehydrogenase type I inhibitor. 11β-HSD1-IN-27 inhibits catalytic activity of target enzymes in cell-based assays. 11β-HSD1-IN-27 exhibits moderate stability in mouse and human liver microsomes.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

CAS 番号: 946400-19-7
分子式: C₁₉H₁₆ClF₄N₃O₂S
分子量:461.86

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

11β-HSD1-IN-27 構造式

CAS 番号: 946400-19-7

容量

価格（税別）

在庫状況

数量

Amount: USD 0.00

* アイテムを追加する前、数量をご選択ください

Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

IC₅₀ & Target^[1]

11β-HSD1

体外実験

11β-HSD1-IN-27 (compound 19) potently inhibits human 11β-HSD1 in stable CHO cells expressing the enzyme, with an IC₅₀ of 0.016 μM^[1].
11β-HSD1-IN-27 potently inhibits mouse 11β-HSD1 in stable CHO cells expressing the enzyme, with an IC₅₀ of 0.010 μM^[1].
11β-HSD1-IN-27 (11-point dilutions; 30 min compound incubation, 120 min total) inhibits mouse 11β-HSD1 in stable CHO cells expressing the enzyme in the presence of 10% human serum, with an IC₅₀ of 0.398 μM^[1].
11β-HSD1-IN-27 (1 μM; up to 30 min) has a metabolic half-life of 13 min in mouse liver microsomes^[1].
11β-HSD1-IN-27 (1 μM; up to 30 min) has a metabolic half-life of 14 min in human liver microsomes^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

化学情報

CAS 番号 946400-19-7
分子量 461.86
分子式 C₁₉H₁₆ClF₄N₃O₂S
SMILES

FC(F)(C1=C(C=CC(F)=C1)N2C[C@H](N(CC2)S(=O)(C3=C(C=C(C=C3)C#N)Cl)=O)C)F
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

取扱説明書 (2659 KB)

参考文献

[1]. Wan ZK, et al. Efficacious 11beta-hydroxysteroid dehydrogenase type I inhibitors in the diet-induced obesity mouse model. Journal of medicinal chemistry. 2009 Sep 10;52(17):5449-61. [Content Brief]

Calculators

モル濃度計算機

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

濃度濃度

体積体積

分子量分子量

希釈計算機

濃度 _(開始) × 体積 _(開始) = 濃度 _(終了) × 体積 _(終了)

濃度 _(開始) 濃度 _(開始)

体積 _(開始) 体積 _(開始)

濃度 _(終了) 濃度 _(終了)

体積 _(終了) 体積 _(終了)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

お問い合わせ在庫あり

Other size

お問い合わせ