Art. -Nr.: HY-B1372

2,2,2-Tribromoethanol

Name: 2,2,2-Tribromoethanol
Brand: MedChemExpress
SKU: HY-B1372
Price: 30.00 USD
Availability: InStock
Rating: 5 (24 reviews)

(Synonyms: Tribromoethyl alcohol; Narcolan)

24 Cited Publications

Kundenbewertung

Based on 24 publication(s) in Google Scholar

2,2,2-Tribromoethanol (Tribromoethyl alcohol) is an injectable compound used for general anesthesia. 2,2,2-Tribromoethanol induces general anesthesia through inhibition of the respiratory/cardiovascular centers, cardiac depression, and chemical restraint, and produces dose-dependent surgical anesthetic effects. 2,2,2-Tribromoethanol is commonly used for anesthesia in rodents.

Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.

Reinheit : 99.97%
CAS. Nr.: 75-80-9
Formel: C₂H₃Br₃O
Molecular Weight:282.76

Speicherung:

4°C, protect from light

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

2,2,2-Tribromoethanol Chemical Structure

CAS. Nr.: 75-80-9

Größe

Preis

Verfügbarkeit

Menge

Amount: USD 0.00

* Bitte wählen Sie Menge, bevor Sie Artikel hinzufügen.

Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- In Vivo
Chemical Information
Publications (24)
Lösungsmittel & Löslichkeit
- In Vitro
- In Vivo
Reinheit & Dokumentation
Verweise
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

In Vivo

2,2,2-Tribromoethanol (250 mg/kg b.w.; i.p.; single injection) produces longer anaesthesia and delayed recovery in Nrf2 transcriptional knockout mice than in wild-type mice and has genotype-dependent effects on colon inflammation and collagen deposition^[1].
2,2,2-Tribromoethanol (125-500 mg/kg; i.p.; single injection) induces stable, dose-dependent anesthesia in male and female ICR mice from three sources, with similar anesthetic responses across sources and longer anesthesia and recovery in females at higher doses^[2].
In healthy CD-1 mice, 2,2,2-Tribromoethanol (400 mg/kg; i.p.; single injection per anesthetic event) produces rapid light anesthetic effect with rapid recovery, no anesthetic mortality, and no evidence of local or systemic inflammation^[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS. Nr. 75-80-9
Appearance Solid
Molecular Weight 282.76
Formel C₂H₃Br₃O
Color White to yellow
SMILES

BrC(Br)(Br)CO
Synonyms

Tribromoethyl alcohol; Narcolan
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

4°C, protect from light

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Publications (24)

All

Sort by:

Journal Impact Factor

Nat Commun

2026 Sep 11;17(1):10719. PMID: 42864341
Adv Sci (Weinh)

Cholesterol Promotes Lung Adenocarcinoma Brain Metastasis by Stabilizing EGFR Protein to Drive EMT, Metabolic Reprogramming, and Premetastatic Niche Formation. [Abstract]

2026 Mar;13(17):e73843. PMID: 41562200
Chem Eng J

2026 Feb 24.
J Hazard Mater

Coexposure to heat stress and polystyrene nanoplastics induces neuroinflammation and cognitive impairment via oxidative stress-NLRP6-pyroptosis axis. [Abstract]

2026 Jun 15:511:142151. PMID: 42030847
J Transl Med

Human neural stem cell-derived exosomes activate PINK1/Parkin pathway to protect against oxidative stress-induced neuronal injury in ischemic stroke. [Abstract]

2025 Apr 5;23(1):402. PMID: 40188077
Neural Regen Res

2026 Sep 30. PMID: 42821388
Free Radic Biol Med

Endoplasmic reticulum stress-induced iRhom2 up-regulation promotes macrophage-regulated cardiac inflammation and lipid deposition in high fat diet (HFD)-challenged mice: Intervention of fisetin and metformin. [Abstract]

2019 Sep:141:67-83. PMID: 31153974
EMBO Mol Med

Isoginkgetin antagonizes ALS pathologies in its animal and patient iPSC models via PINK1-Parkin-dependent mitophagy. [Abstract]

2025 Oct 15. PMID: 41094045
Stem Cell Res Ther

Migrasomes derived from human umbilical cord mesenchymal stem cells: a new therapeutic agent for ovalbumin-induced asthma in mice. [Abstract]

2025 Jan 26;16(1):26. PMID: 39865246
Cell Prolif

In vivo development and single-cell transcriptome profiling of human brain organoids. [Abstract]

2022 Mar;55(3):e13201. PMID: 35141969
Cell Mol Neurobiol

Activation of the Reverse Cholesterol Transport Pathway: A Strategy to Ameliorate Lipid Metabolic Dyshomeostasis in the Microenvironment Following Spinal Cord Injury. [Abstract]

2026 Jun 19. PMID: 42321551
Cancer Cell Int

DDX52 knockdown inhibits the growth of prostate cancer cells by regulating c-Myc signaling. [Abstract]

2021 Aug 16;21(1):430. PMID: 34399732
J Ethnopharmacol

Miao medicine Jinshanxiaoke granules alleviates MASLD via Ampk/Ppar-α and Pi3k/Akt-mediated restoration of hepatic lipid homeostasis. [Abstract]

2026 Jul 15:366:121677. PMID: 41990925
Biochem Pharmacol

Obacunone mitigates cisplatin-induced ototoxicity by activating CRHBP-mediated autophagy. [Abstract]

2026 Jan 27:247:117759. PMID: 41611132
Life Sci

Activation of autophagy-lysosome function by MiT/TFE transcription factors ameliorates pulmonary endothelial injury. [Abstract]

2026 May 25:400:124469. PMID: 42184923
Pharm Biol

Small ubiquitin-related modifier (SUMO)ylation of SIRT1 mediates (-)-epicatechin inhibited- differentiation of cardiac fibroblasts into myofibroblasts. [Abstract]

2022 Dec;60(1):1762-1770. PMID: 36086802
Respir Res

Vacuum-stabilized lung window enables real-time and simultaneous imaging of vascular and calcium responses to hypoxia in vivo. [Abstract]

2026 Jun 10. PMID: 42271323
Int Immunopharmacol

ACT001 suppressing M1 polarization against inflammation via NF-κB and STAT1 signaling pathways alleviates acute lung injury in mice. [Abstract]

2022 Sep:110:108944. PMID: 35728304
J Nutr Biochem

Oral flavonoid fisetin treatment protects against prolonged high-fat-diet-induced cardiac dysfunction by regulation of multicombined signaling. [Abstract]

2020 Mar:77:108253. PMID: 31835147
Sci Rep

2026 Sep 25.
Mediators Inflamm

LncRNA NEAT1 Knockdown Alleviates Macrophage Ferroptosis and Atherosclerosis by Suppressing STAT3 Activation. [Abstract]

2025 Nov 12:2025:8862449. PMID: 41268533
Immunobiology

Exosomes derived from baicalin-pretreated bone marrow mesenchymal stem cells inactivate the TLR4/MyD88/NF-kB pathway to improve asthma. [Abstract]

2025 Jul 16;230(4):153103. PMID: 40695068
Res Sq

2026 May 4.
Research Square Preprint

2021 May.

Lösungsmittel & Löslichkeit

In Vitro:

DMSO : ≥ 125 mg/mL (442.07 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Ethanol : ≥ 100 mg/mL (353.66 mM)

H₂O : 2 mg/mL (7.07 mM; Need ultrasonic)

* "≥" means soluble, but saturation unknown.

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

3.5366 mL

17.6828 mL

35.3657 mL

5 mM

0.7073 mL

3.5366 mL

7.0731 mL

10 mM

0.3537 mL

1.7683 mL

3.5366 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

Stock Solution Working Solution

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% EtOH 40% PEG300 5% Tween-80 45% Saline

Solubility: ≥ 2.5 mg/mL (8.84 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

Taking 1 mL working solution as an example, add 100 μL EtOH stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

Protocol 2

Add each solvent one by one: 10% EtOH 90% (20% SBE-β-CD in Saline)

Solubility: ≥ 2.5 mg/mL (8.84 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

Taking 1 mL working solution as an example, add 100 μL EtOH stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

Protocol 3

Add each solvent one by one: 10% EtOH 90% Corn Oil

Solubility: ≥ 2.5 mg/mL (8.84 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Taking 1 mL working solution as an example, add 100 μL EtOH stock solution (25.0 mg/mL) to 900 μL Corn oil, and mix evenly.

Protocol 4

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline

Solubility: ≥ 2.08 mg/mL (7.36 mM); Clear solution

This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown).

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

Protocol 5

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)

Solubility: ≥ 2.08 mg/mL (7.36 mM); Clear solution

This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown).

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

Protocol 6

Add each solvent one by one: 10% DMSO 90% Corn Oil

Solubility: ≥ 2.08 mg/mL (7.36 mM); Clear solution

This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 900 μL Corn oil, and mix evenly.

Working Solution

For the following dissolution methods, please prepare the working solution directly:

It is recommended to prepare fresh solutions and use them promptly within a short period of time.

The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: Saline

Solubility: 10 mg/mL (35.37 mM); Clear solution; Need ultrasonic and warming and heat to 60°C

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage Dosage
mg/kg
Animal Weight (Per Animal) Animal Weight (Per Animal)
g
Dosing Volume (Per Animal) Dosing Volume (Per Animal)
μL
Number of Animals Number of Animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

%
DMSO +

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
%
+
+
%
Tween-80 + +
%
Saline +

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Working solution concentration: 0.22 mg/mL

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (285 KB)
SDS (396 KB)
- English - EN (396 KB)
- Français - FR (396 KB)
- Deutsch - DE (396 KB)
- Norwegian - NO (396 KB)
- Español - ES (396 KB)
- Swedish - SV (396 KB)
- Italian - IT (396 KB)
- Korean - KR (396 KB)
- Portuguese - PT (396 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Kopacz A, et al. Nrf2 transcriptional activity in the mouse affects the physiological response to tribromoethanol. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2020 Aug;128:110317.

[2]. Lee MR, et al. Comparison of the anesthetic effects of 2,2,2-tribromoethanol on ICR mice derived from three different sources. Laboratory animal research. 2018 Dec;34(4):270-278.

[3]. Roniérik P. Vieira, et al. Styrene ATRP using the new initiator 2,2,2-tribromoethanol: Experimental and simulation approach. POLYMER ENGINEERING AND SCIENCE. 02 June 2015.

[4]. Black C, et al. Revisiting tribromoethanol as a safe and effective murine anesthetic for veterinary clinical and biomedical research. Veterinary immunology and immunopathology. 2025 Apr;282:110909.

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
H₂O / Ethanol / DMSO	1 mM	3.5366 mL	17.6828 mL	35.3657 mL	88.4142 mL
H₂O / Ethanol / DMSO	5 mM	0.7073 mL	3.5366 mL	7.0731 mL	17.6828 mL
Ethanol / DMSO	10 mM	0.3537 mL	1.7683 mL	3.5366 mL	8.8414 mL
	15 mM	0.2358 mL	1.1789 mL	2.3577 mL	5.8943 mL
	20 mM	0.1768 mL	0.8841 mL	1.7683 mL	4.4207 mL
	25 mM	0.1415 mL	0.7073 mL	1.4146 mL	3.5366 mL
	30 mM	0.1179 mL	0.5894 mL	1.1789 mL	2.9471 mL
	40 mM	0.0884 mL	0.4421 mL	0.8841 mL	2.2104 mL
	50 mM	0.0707 mL	0.3537 mL	0.7073 mL	1.7683 mL
	60 mM	0.0589 mL	0.2947 mL	0.5894 mL	1.4736 mL
	80 mM	0.0442 mL	0.2210 mL	0.4421 mL	1.1052 mL
	100 mM	0.0354 mL	0.1768 mL	0.3537 mL	0.8841 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Bioz

Keywords

2,2,2-Tribromoethanol

24 Cited Publications

100 mg Angebot einholen

Subscribe to the

MedChemExpress

Newsletter

Produktname:
Art. -Nr.:
Menge:
MCE Japan Authorized Agent:

Produktname:
CAS. Nr.:
Species:
Reinheit:
Menge:

2,2,2-Tribromoethanol

Publications Citing Use of MedChemExpress (MCE) 2,2,2-Tribromoethanol