Tribromoethyl alcohol
Based on 20 publication(s) in Google Scholar
Tribromoethyl alcohol (2,2,2-Tribromoethanol) is used to animals, particularly rodents, before surgery.
For research use only. We do not sell to patients.
- Purity: 99.97%
- CAS No.: 75-80-9
- Formula: C2H3Br3O
- Molecular Weight:282.76
-
Storage:
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
-
Solvent & Solubility
- Purity & Documentation
- References
-
Help & FAQs
Publications Citing Use of MedChemExpress (MCE) Tribromoethyl alcohol
More- Adv Sci (Weinh). 2026 Mar;13(17):e73843. [Abstract]
- Chem Eng J. 2026 Feb 24.
- J Hazard Mater. 2026 Jun 15:511:142151. [Abstract]
- EMBO Mol Med. 2025 Oct 15. [Abstract]
- Free Radic Biol Med. 2019 Sep:141:67-83. [Abstract]
- J Transl Med. 2025 Apr 5;23(1):402. [Abstract]
- Stem Cell Res Ther. 2025 Jan 26;16(1):26. [Abstract]
- Cancer Cell Int. 2021 Aug 16;21(1):430. [Abstract]
- Biochem Pharmacol. 2026 Jan 27:247:117759. [Abstract]
- Cell Prolif. 2022 Mar;55(3):e13201. [Abstract]
- J Ethnopharmacol. 2026 Jul 15:366:121677. [Abstract]
- Life Sci. 2026 May 25:400:124469. [Abstract]
- Respir Res. 2026 Jun 10. [Abstract]
- The Journal of Nutritional Biochemistry. 2020 Mar;77:108253. [Abstract]
- Pharm Biol. 2022 Dec;60(1):1762-1770. [Abstract]
- Int Immunopharmacol. 2022 Sep:110:108944. [Abstract]
- Mediators Inflamm. 2025 Nov 12:2025:8862449. [Abstract]
- Immunobiology. 2025 Jul 16;230(4):153103. [Abstract]
- Res Sq. 2026 May 4.
- Research Square Preprint. 2021 May.
Biological Activity
Tribromoethanol (10 g) was mixed with 10 mL of tert-amyl alcohol, then diluted this stock with sterile saline to a 2.5% solution. Injected intraperitoneally this 2.5% solution as a single dose of 333 mg/kg[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
-
CAS No. 75-80-9
-
Appearance Solid
-
Molecular Weight 282.76
-
Formula C2H3Br3O
-
Color White to yellow
-
SMILES
BrC(Br)(Br)CO
-
Synonyms
2,2,2-Tribromoethanol; Narcolan
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Publications (20)
-
Journal Impact Factor
-
Most Recent
-
Adv Sci (Weinh)
Cholesterol Promotes Lung Adenocarcinoma Brain Metastasis by Stabilizing EGFR Protein to Drive EMT, Metabolic Reprogramming, and Premetastatic Niche Formation. [Abstract]2026 Mar;13(17):e73843. PMID: 41562200 -
-
J Hazard Mater
Coexposure to heat stress and polystyrene nanoplastics induces neuroinflammation and cognitive impairment via oxidative stress-NLRP6-pyroptosis axis. [Abstract]2026 Jun 15:511:142151. PMID: 42030847 -
EMBO Mol Med
Isoginkgetin antagonizes ALS pathologies in its animal and patient iPSC models via PINK1-Parkin-dependent mitophagy. [Abstract]2025 Oct 15. PMID: 41094045 -
Free Radic Biol Med
Endoplasmic reticulum stress-induced iRhom2 up-regulation promotes macrophage-regulated cardiac inflammation and lipid deposition in high fat diet (HFD)-challenged mice: Intervention of fisetin and metformin. [Abstract]2019 Sep:141:67-83. PMID: 31153974 -
J Transl Med
Human neural stem cell-derived exosomes activate PINK1/Parkin pathway to protect against oxidative stress-induced neuronal injury in ischemic stroke. [Abstract]2025 Apr 5;23(1):402. PMID: 40188077 -
Stem Cell Res Ther
Migrasomes derived from human umbilical cord mesenchymal stem cells: a new therapeutic agent for ovalbumin-induced asthma in mice. [Abstract]2025 Jan 26;16(1):26. PMID: 39865246 -
Cancer Cell Int
DDX52 knockdown inhibits the growth of prostate cancer cells by regulating c-Myc signaling. [Abstract]2021 Aug 16;21(1):430. PMID: 34399732 -
Biochem Pharmacol
Obacunone mitigates cisplatin-induced ototoxicity by activating CRHBP-mediated autophagy. [Abstract]2026 Jan 27:247:117759. PMID: 41611132 -
Cell Prolif
2022 Mar;55(3):e13201. PMID: 35141969 -
J Ethnopharmacol
Miao medicine Jinshanxiaoke granules alleviates MASLD via Ampk/Ppar-α and Pi3k/Akt-mediated restoration of hepatic lipid homeostasis. [Abstract]2026 Jul 15:366:121677. PMID: 41990925 -
Life Sci
Activation of autophagy-lysosome function by MiT/TFE transcription factors ameliorates pulmonary endothelial injury. [Abstract]2026 May 25:400:124469. PMID: 42184923 -
Respir Res
Vacuum-stabilized lung window enables real-time and simultaneous imaging of vascular and calcium responses to hypoxia in vivo. [Abstract]2026 Jun 10. PMID: 42271323 -
The Journal of Nutritional Biochemistry
Oral flavonoid fisetin treatment protects against prolonged high-fat-diet-induced cardiac dysfunction by regulation of multicombined signaling. [Abstract]2020 Mar;77:108253. PMID: 31835147 -
Pharm Biol
Small ubiquitin-related modifier (SUMO)ylation of SIRT1 mediates (-)-epicatechin inhibited- differentiation of cardiac fibroblasts into myofibroblasts. [Abstract]2022 Dec;60(1):1762-1770. PMID: 36086802 -
Int Immunopharmacol
ACT001 suppressing M1 polarization against inflammation via NF-κB and STAT1 signaling pathways alleviates acute lung injury in mice. [Abstract]2022 Sep:110:108944. PMID: 35728304 -
Mediators Inflamm
LncRNA NEAT1 Knockdown Alleviates Macrophage Ferroptosis and Atherosclerosis by Suppressing STAT3 Activation. [Abstract]2025 Nov 12:2025:8862449. PMID: 41268533 -
Immunobiology
Exosomes derived from baicalin-pretreated bone marrow mesenchymal stem cells inactivate the TLR4/MyD88/NF-kB pathway to improve asthma. [Abstract]2025 Jul 16;230(4):153103. PMID: 40695068 -
-
Solvent & Solubility
DMSO : ≥ 125 mg/mL (442.07 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Ethanol : ≥ 100 mg/mL (353.66 mM)
H2O : 2 mg/mL (7.07 mM; Need ultrasonic)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% EtOH 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL (8.84 mM); Clear solution
This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL EtOH stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Add each solvent one by one: 10% EtOH 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.5 mg/mL (8.84 mM); Clear solution
This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL EtOH stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Add each solvent one by one: 10% EtOH 90% Corn Oil
Solubility: ≥ 2.5 mg/mL (8.84 mM); Clear solution
This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Taking 1 mL working solution as an example, add 100 μL EtOH stock solution (25.0 mg/mL) to 900 μL Corn oil, and mix evenly.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.08 mg/mL (7.36 mM); Clear solution
This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.08 mg/mL (7.36 mM); Clear solution
This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Please enter the basic information of animal experiments:
-
-
-
-
Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
-
%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
-
%+
-
+%Tween-80 + +
-
%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL. * In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Purity & Documentation
-
Data Sheet (274 KB)
-
SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
-
Handling Instructions (2659 KB)
References
[1]. Hill WA, et al. Repeated administration of tribromoethanol in C57BL/6NHsd mice. J Am Assoc Lab Anim Sci. 2013 Mar;52(2):176-179. [Content Brief]
[2]. J A Nick, et al. Role of p38 mitogen-activated protein kinase in a murine model of pulmonary inflammation. J Immunol 2000 Feb 15;164(4):2151-9. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O / Ethanol / DMSO | 1 mM | 3.5366 mL | 17.6828 mL | 35.3657 mL | 88.4142 mL |
| 5 mM | 0.7073 mL | 3.5366 mL | 7.0731 mL | 17.6828 mL | |
| Ethanol / DMSO | 10 mM | 0.3537 mL | 1.7683 mL | 3.5366 mL | 8.8414 mL |
| 15 mM | 0.2358 mL | 1.1789 mL | 2.3577 mL | 5.8943 mL | |
| 20 mM | 0.1768 mL | 0.8841 mL | 1.7683 mL | 4.4207 mL | |
| 25 mM | 0.1415 mL | 0.7073 mL | 1.4146 mL | 3.5366 mL | |
| 30 mM | 0.1179 mL | 0.5894 mL | 1.1789 mL | 2.9471 mL | |
| 40 mM | 0.0884 mL | 0.4421 mL | 0.8841 mL | 2.2104 mL | |
| 50 mM | 0.0707 mL | 0.3537 mL | 0.7073 mL | 1.7683 mL | |
| 60 mM | 0.0589 mL | 0.2947 mL | 0.5894 mL | 1.4736 mL | |
| 80 mM | 0.0442 mL | 0.2210 mL | 0.4421 mL | 1.1052 mL | |
| 100 mM | 0.0354 mL | 0.1768 mL | 0.3537 mL | 0.8841 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Tribromoethyl alcohol Related Classifications
HY-B1372 Related Classifications
Powered by Bioz