2',3'-cGAMP-d8 ammonium
Based on 1 Customer Validation
2',3'-cGAMP-d8 (2'-3'-Cyclic GMP-AMP-d8) ammonium is the deuterated-labeled 2',3'-cGAMP ammonium. 2',3'-cGAMP (2'-3'-cyclic GMP-AMP) is a endogenous cGAMP in mammalian cells. 2',3'-cGAMP binds to STING with a high affinity and is a potent inducer of interferon-β (IFNβ). 2',3'-cGAMP is produced in mammalian cells in response to DNA in the cytoplasm.
For research use only. We do not sell to patients.
- Purity: 99.88%
- Formula: C20H22D8N12O13P2
- Molecular Weight:716.52
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Storage:
Solution, -20°C, 2 years
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
All Endogenous Metabolite Isoforms
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Biological Activity
Description
IC50 & Target
STING, IFNβ[1]
In Vitro
Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Application
1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Chemical Information
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Appearance Liquid
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Molecular Weight 716.52
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Formula C20H22D8N12O13P2
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Color Colorless to light yellow
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SMILES
O=P1(O[C@@]2([2H])[C@H]([C@@H](O[C@@]2(C([2H])(OP(O[C@]3([C@@H](O[C@]([2H])(C([2H])(O1)[2H])[C@]3(O)[2H])N4C=NC5=C4NC(N)=NC5=O)[H])([O-])=O)[2H])[2H])N6C=NC7=C6N=CN=C7N)O)[O-].[NH4+].[NH4+]
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Synonyms
2'-3'-Cyclic GMP-AMP-d8 ammonium
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Solution, -20°C, 2 years
Purity & Documentation
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Data Sheet (274 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
2',3'-cGAMP-d8 ammonium Related Classifications
HY-100564BS Related Classifications
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