2-Aminobenzonitrile
Based on 1 Customer Validation
2-Aminobenzonitrile is an aminobenzonitrile synthetic building block and an arylamine coupling ligand. 2-Aminobenzonitrile participates in the Friedländer condensation reaction. 2-Aminobenzonitrile is an o-cyanoaniline precursor that can be used to synthesize cyclic N-linked C8,N7-dG adducts. 2-Aminobenzonitrile is used to prepare Tacrine (HY-111338) and its analogs.
For research use only. We do not sell to patients.
- Purity : 99.96%
- CAS No.: 1885-29-6
- Formula: C7H6N2
- Molecular Weight:118.14
-
Storage:
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
-
Solvent & Solubility
- Purity & Documentation
- References
-
Help & FAQs
-
HY-W015823
4-Hydroxybenzyl cyanideAromatic Nitrile -
HY-12452
DPNERβ Agonist -
HY-W012869
2-HydroxybenzonitrileBiochemical Reagent -
HY-W017601
2-ChlorobenzonitrileAntimalarial Agent -
HY-Y0146
4-BromophenylacetonitrilePROTAC Linker -
HY-B1987
2,6-Dichlorobenzonitrile -
HY-W015823R
4-Hydroxybenzyl cyanide (Standard) -
HY-W015052
DiphenylacetonitrileBiochemical Reagent -
HY-Y0259
4-ChlorobutyronitrilePROTAC Linker -
HY-W041621
5-ChloropentanenitrilePROTAC Linker -
HY-Y0900
5-BromovaleronitrilePROTAC Linker
Biological Activity
Description
In Vitro
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
-
CAS No. 1885-29-6
-
Appearance Solid
-
Molecular Weight 118.14
-
Formula C7H6N2
-
Color White to light brown
-
SMILES
N#CC1=C(N)C=CC=C1
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Solvent & Solubility
In Vitro:
DMSO : 100 mg/mL (846.45 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
In Vivo:
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.5 mg/mL (21.16 mM); Clear solution
This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:
-
-
-
-
Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
-
%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
-
%+
-
+%Tween-80 + +
-
%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL. * In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Purity & Documentation
-
Data Sheet (278 KB)
-
SDS (394 KB)
- English - EN (394 KB)
- Français - FR (394 KB)
- Deutsch - DE (394 KB)
- Norwegian - NO (394 KB)
- Español - ES (394 KB)
- Swedish - SV (394 KB)
- Italian - IT (394 KB)
- Korean - KR (394 KB)
- Portuguese - PT (394 KB)
-
Handling Instructions (2659 KB)
References
[1]. Camps P, et al. Tacrine-huperzine A hybrids (huprines): a new class of highly potent and selective acetylcholinesterase inhibitors of interest for the treatment of Alzheimer's disease. Mini reviews in medicinal chemistry. 2001 Jul;1(2):163-74. [Content Brief]
[2]. Useini L, et al. Carboranyl Analogues of Mefenamic Acid and Their Biological Evaluation. ACS omega. 2022 Jul 19;7(28):24282-24291. [Content Brief]
[3]. Manning TW, et al. Structure of an unusual tetracyclic deoxyguanosine adduct: implications for frameshift mutagenicity of ortho-cyano nitroanilines. Chemical Research in Toxicology. 2020 Feb 17;33(2):584-93. [Content Brief]
[4]. Kulkarni AS, et al. Silicon incorporated tacrine: design, synthesis, and evaluation of biological and pharmacokinetic parameters. RSC medicinal chemistry. 2025 Jun 18;16(6):2603-2614. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 8.4645 mL | 42.3227 mL | 84.6453 mL | 211.6133 mL |
| 5 mM | 1.6929 mL | 8.4645 mL | 16.9291 mL | 42.3227 mL | |
| 10 mM | 0.8465 mL | 4.2323 mL | 8.4645 mL | 21.1613 mL | |
| 15 mM | 0.5643 mL | 2.8215 mL | 5.6430 mL | 14.1076 mL | |
| 20 mM | 0.4232 mL | 2.1161 mL | 4.2323 mL | 10.5807 mL | |
| 25 mM | 0.3386 mL | 1.6929 mL | 3.3858 mL | 8.4645 mL | |
| 30 mM | 0.2822 mL | 1.4108 mL | 2.8215 mL | 7.0538 mL | |
| 40 mM | 0.2116 mL | 1.0581 mL | 2.1161 mL | 5.2903 mL | |
| 50 mM | 0.1693 mL | 0.8465 mL | 1.6929 mL | 4.2323 mL | |
| 60 mM | 0.1411 mL | 0.7054 mL | 1.4108 mL | 3.5269 mL | |
| 80 mM | 0.1058 mL | 0.5290 mL | 1.0581 mL | 2.6452 mL | |
| 100 mM | 0.0846 mL | 0.4232 mL | 0.8465 mL | 2.1161 mL |
2-Aminobenzonitrile Related Classifications
HY-W012882 Related Classifications
Powered by Bioz