2-Linoleoyl glycerol
Based on 1 Customer Validation
2-Linoleoyl glycerol (2-Monolinolein) is a partial CB1 receptor agonist with a pEC50 of 4.781. 2-Linoleoyl glycerol activates the hCB1 receptor. 2-Linoleoyl glycerol does not induce an increase in intracellular free Ca2+. 2-Linoleoyl glycerol can be used in the research of neurological disorders.
For research use only. We do not sell to patients.
- Purity : 99.9%
- CAS No.: 3443-82-1
- Formula: C21H38O4
- Molecular Weight:354.52
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Storage:
Solution, -20°C, 2 years
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Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Protocols
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
Description
IC50 & Target
[1]|
CB1R 4.781 (pEC50) |
In Vitro
2-Linoleoyl glycerol (1-50 μM; 4 h) acts as a low-affinity partial agonist of the CB1 receptor in Tango CNR1-bla U2OS cells, with a pEC50 value of 4.781. Its CB1-dependent activity is potentiated by JZL195 and completely inhibited by AM251[1].
2-Linoleoyl glycerol (10 μM) does not induce an increase in intracellular free calcium levels in NG108-15 cells[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.
Chemical Information
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CAS No. 3443-82-1
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Appearance Liquid
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Molecular Weight 354.52
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Formula C21H38O4
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Color Colorless to light yellow
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SMILES
CCCCC/C=C\C/C=C\CCCCCCCC(OC(CO)CO)=O
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Synonyms
2-Monolinolein; 2-Monolinoleoylglycerol
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Solution, -20°C, 2 years
Protocols
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Ca2+ Staining Technique
Ca2+ staining is an experimental technique that utilizes specific fluorescent probes (such as Fluo-4 AM, Fura-2, etc.) to qualitatively or quantitatively detect dynamic changes in intracellular Ca2+ concentrations; this is achieved by monitoring the changes in fluorescent signals generated when these probes bind to free intracellular calcium ions. The underlying principle relies primarily on the presence of chelating groups within the probe's molecular structure that possess high affinity for calcium ions.
Purity & Documentation
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Data Sheet (262 KB)
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SDS (605 KB)
- English - EN (605 KB)
- Français - FR (605 KB)
- Deutsch - DE (605 KB)
- Norwegian - NO (605 KB)
- Español - ES (605 KB)
- Swedish - SV (605 KB)
- Italian - IT (605 KB)
- Korean - KR (605 KB)
- Portuguese - PT (605 KB)
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Handling Instructions (2659 KB)
References
[1]. Lu L, et al. 2-Linoleoylglycerol Is a Partial Agonist of the Human Cannabinoid Type 1 Receptor that Can Suppress 2-Arachidonolyglycerol and Anandamide Activity. Cannabis Cannabinoid Res. 2019;4(4):231-239. Published 2019 Dec 9. [Content Brief]
[2]. Sugiura T, et al. 2-Arachidonoylglycerol, a putative endogenous cannabinoid receptor ligand, induces rapid, transient elevation of intracellular free Ca2+ in neuroblastoma x glioma hybrid NG108-15 cells. Biochem Biophys Res Commun. 1996;229(1):58-64. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
2-Linoleoyl glycerol Related Classifications
HY-130311 Related Classifications
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