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Cat. No.: HY-N0375A

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3-epi-18β-Glycyrrhetinic acid

3-epi-18β-Glycyrrhetinic acid is an inhibitor of 11β-HSD1 and 11β-HSD2, with an IC₅₀ of 0.17 μM against 11β-HSD2. 3-epi-18β-Glycyrrhetinic acid acts as a weak substrate for sulfotransferase 2A1. It serves as a biomarker for the toxicity of licorice-related pseudoaldosteronism. 3-epi-18β-Glycyrrhetinic acid is applicable to studies related to pseudoaldosteronism.

For research use only. We do not sell to patients.

CAS No.: 90365-60-9
Formula: C₃₀H₄₆O₄
Molecular Weight:470.69

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

3-epi-18β-Glycyrrhetinic acid Chemical Structure

CAS No.: 90365-60-9

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- Cellular Effect
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
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Classifications
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Biological Activity

Description

IC₅₀ & Target

^[1]^[3]

11β-HSD1

11β-HSD2

0.17 μM (IC₅₀)

All SULT Isoforms :

SULT1

Cellular Effect

Cell Line	Type	Value	Description	References
518A2	IC₅₀	30 μmol Compound: 3	Cytotoxicity against human 518A2 cells after 96 hrs by SRB assay Cytotoxicity against human 518A2 cells after 96 hrs by SRB assay	[PMID: 21959232]
A-431	IC₅₀	30 μmol Compound: 3	Cytotoxicity against human A431 cells after 96 hrs by SRB assay Cytotoxicity against human A431 cells after 96 hrs by SRB assay	[PMID: 21959232]
A549	IC₅₀	30 μmol Compound: 3	Cytotoxicity against human A549 cells after 96 hrs by SRB assay Cytotoxicity against human A549 cells after 96 hrs by SRB assay	[PMID: 21959232]
DLD-1	IC₅₀	30 μmol Compound: 3	Cytotoxicity against human DLD1 cells after 96 hrs by SRB assay Cytotoxicity against human DLD1 cells after 96 hrs by SRB assay	[PMID: 21959232]
HCT-116	IC₅₀	30 μmol Compound: 3	Cytotoxicity against human HCT116 cells after 96 hrs by SRB assay Cytotoxicity against human HCT116 cells after 96 hrs by SRB assay	[PMID: 21959232]
HCT-8	IC₅₀	30 μmol Compound: 3	Cytotoxicity against human HCT8 cells after 96 hrs by SRB assay Cytotoxicity against human HCT8 cells after 96 hrs by SRB assay	[PMID: 21959232]
HT-29	IC₅₀	30 μmol Compound: 3	Cytotoxicity against human HT-29 cells after 96 hrs by SRB assay Cytotoxicity against human HT-29 cells after 96 hrs by SRB assay	[PMID: 21959232]
MCF7	IC₅₀	30 μmol Compound: 3	Cytotoxicity against human MCF7 cells after 96 hrs by SRB assay Cytotoxicity against human MCF7 cells after 96 hrs by SRB assay	[PMID: 21959232]
SW-1736	IC₅₀	30 μmol Compound: 3	Cytotoxicity against human SW1736 cells after 96 hrs by SRB assay Cytotoxicity against human SW1736 cells after 96 hrs by SRB assay	[PMID: 21959232]

In Vitro

3-epi-18β-Glycyrrhetinic acid (Compound 12) (1 μM; 10 min) potently inhibits recombinant h11β-HSD1 and h11β-HSD2, with inhibition rates of 97.4% and 97.0% at the concentration of 1 μM, respectively^[1].
3-epi-18β-Glycyrrhetinic acid (30 min) potently inhibits 11β-HSD2 in vitro, with a mean IC₅₀ of 0.17 μM^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 90365-60-9
Molecular Weight 470.69
Formula C₃₀H₄₆O₄
SMILES

C[C@]12[C@@]([C@]3(C)[C@@](CC1)(C(C)(C)[C@H](O)CC3)[H])(C(=O)C=C4[C@@]2(C)CC[C@]5(C)[C@]4(C[C@](C(O)=O)(C)CC5)[H])[H]
Structure Classification
- Terpenoids
- Triterpenes
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Beseda I, et al. Synthesis of glycyrrhetinic acid derivatives for the treatment of metabolic diseases. Bioorganic & medicinal chemistry. 2010 Jan 01;18(1):433-54. [Content Brief]

[2]. Sakoda R, et al. Stereoisomerism at the 3-position of glycyrrhetinic acid affects pseudoaldosteronism-related toxicokinetics. Drug metabolism and disposition: the biological fate of chemicals. 2025 Nov;53(11):100180. [Content Brief]

[3]. Sakoda R, et al. 3--18-Glycyrrhetinic Acid or Its Glucuronide, the Metabolites of Glycyrrhizinic Acid with Individual Differences, Correlated with Diagnostic Marker for Licorice-Induced Pseudoaldosteronism in Humans. Drug metabolism and disposition: the biological fate of chemicals. 2024 Nov 15;52(12):1407-1416. [Content Brief]

[4]. Yoshino T, et al. The Role of 3-epi-18β-Glycyrrhetinic Acid and Hepatic Function in Licorice-Induced Pseudohyperaldosteronism. Kidney Int Rep. 2026 Jan 9;11(3):103771. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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