3-Hydroxyanthranilic acid-d3
Based on 1 publication(s) in Google Scholar
3-Hydroxyanthranilic acid-d3 is deuterium-labeled 3-Hydroxyanthranilic acid (HY-W001171).
For research use only. We do not sell to patients.
- Purity: 99.28%
- CAS No.: 1794970-56-1
- Formula: C7H4D3NO3
- Molecular Weight:156.15
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) 3-Hydroxyanthranilic acid-d3
MoreAll Endogenous Metabolite Isoforms
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Biological Activity
Stable or radioisotope-labeled compounds allow precise tracking and quantification of individual atoms in metabolic pathways. Stable isotopes generally do not change molecular properties but may slightly affect metabolic kinetics; radioactive isotopes may interfere with cells. Markers can distinguish endogenous and exogenous metabolites, reduce false positives, and are beneficial to quantification and reconstruction of metabolic pathways[2].
In cell culture or enzymatic reactions, the use of isotope markers can precisely control the concentration and exposure time, making it easy to study metabolic reactions and enzyme activities. Through stable isotope analytical metabolomics (SIRM), cellular metabolic networks can be studied, key metabolic nodes and regulatory mechanisms can be identified, and targets can be provided for compound development.
Isotope-labeled compounds can be used in competition binding experiments to evaluate the affinity and binding kinetics of compounds to receptors to help optimize design. Stable isotope labels are used as internal standards in mass spectrometry analysis to improve analysis accuracy and reproducibility and reduce matrix effect interference[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Isotope labeling can reveal specific steps in metabolic pathways. Using compounds with stable isotope labels at specific locations directly in humans or animal models can also help verify drug mechanisms and evaluate unexpected side effects, improving the accuracy and efficiency of clinical research[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Chemical Information
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CAS No. 1794970-56-1
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Unlabeled Cas 548-93-6
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Appearance Solid
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Molecular Weight 156.15
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Formula C7H4D3NO3
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Color Brown to orange
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SMILES
OC(C1=C(C(O)=C([2H])C([2H])=C1[2H])N)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Publications (1)
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Journal Impact Factor
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Most Recent
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Redox Biol
Reprogramming of the kynurenine pathway impairs NAD+ homeostasis and mediates doxorubicin-induced cardiotoxicity in mice. [Abstract]2026 Feb:89:103957. PMID: 41389767
Solvent & Solubility
DMSO : 50 mg/mL (320.20 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (276 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [Content Brief]
[2]. Smith K A, et al. Soil and environmental analysis[M]. Marcel Dekker Incorporated, 2000.
[3]. Fan T W M, et al. Stable isotope-resolved metabolomics and applications for drug development[J]. Pharmacology & therapeutics, 2012, 133(3): 366-391. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 6.4041 mL | 32.0205 mL | 64.0410 mL | 160.1025 mL |
| 5 mM | 1.2808 mL | 6.4041 mL | 12.8082 mL | 32.0205 mL | |
| 10 mM | 0.6404 mL | 3.2020 mL | 6.4041 mL | 16.0102 mL | |
| 15 mM | 0.4269 mL | 2.1347 mL | 4.2694 mL | 10.6735 mL | |
| 20 mM | 0.3202 mL | 1.6010 mL | 3.2020 mL | 8.0051 mL | |
| 25 mM | 0.2562 mL | 1.2808 mL | 2.5616 mL | 6.4041 mL | |
| 30 mM | 0.2135 mL | 1.0673 mL | 2.1347 mL | 5.3367 mL | |
| 40 mM | 0.1601 mL | 0.8005 mL | 1.6010 mL | 4.0026 mL | |
| 50 mM | 0.1281 mL | 0.6404 mL | 1.2808 mL | 3.2020 mL | |
| 60 mM | 0.1067 mL | 0.5337 mL | 1.0673 mL | 2.6684 mL | |
| 80 mM | 0.0801 mL | 0.4003 mL | 0.8005 mL | 2.0013 mL | |
| 100 mM | 0.0640 mL | 0.3202 mL | 0.6404 mL | 1.6010 mL |
3-Hydroxyanthranilic acid-d3 Related Classifications
HY-W001171S Related Classifications
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