3D-Monophosphoryl Lipid A-5 triethylamine  (Synonyms: 3D-MPLA-5 triethylamine)

3D-Monophosphoryl Lipid A-5 (3D-MPLA-5) triethylamine is a TLR agonist that can be used as an adjuvant for vaccines to enhance their immunogenicity^[1].

Monophosphoryl Lipid A (MPLA) is a low-toxicity derivative of lipopolysaccharide (LPS) that retains the immunologically active lipid A portion of the parent molecule. Both LPS and MPLA are TLR4 agonists, but they signal through different adaptors, MyD88 and TRIF, respectively.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

1621.27

C₈₈H₁₇₀N₃O₂₀P

CCCCCCCCCCCCCC(O[C@H](CCCCCCCCCCC)CC(N[C@@H]1[C@H]([C@@H]([C@H](O[C@H]1OC[C@@H]2[C@H]([C@@H]([C@H]([C@H](O2)O)NC(C[C@H](O)CCCCCCCCCCC)=O)O)O)CO)OP(O)(O)=O)OC(C[C@@H](CCCCCCCCCCC)OC(CCCCCCCCCCCCC)=O)=O)=O)=O.CCN(CC)CC

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Rollman E, et al. Evaluation of immunogenicity and efficacy of combined DNA and adjuvanted protein vaccination in a human immunodeficiency virus type 1/murine leukemia virus pseudotype challenge model[J]. Vaccine, 2007, 25(11): 2145-2154.  [Content Brief]