2. Cell Cycle/DNA Damage
  3. Nucleoside Antimetabolite/Analog
  4. 4-Thiothymidine

4-Thiothymidine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.

For research use only. We do not sell to patients.

4-Thiothymidine Chemical Structure

4-Thiothymidine Chemical Structure

CAS No. : 7236-57-9

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Based on 1 publication(s) in Google Scholar

4-Thiothymidine Related Antibodies

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Description

4-Thiothymidine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1].

Molecular Weight

258.29

Formula

C10H14N2O4S
CAS No.
Appearance

Solid

Color

Light yellow to light brown

SMILES

OC[C@@H]1[C@@H](O)C[C@H](N2C(NC(C(C)=C2)=S)=O)O1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (483.95 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.8716 mL 19.3581 mL 38.7162 mL
5 mM 0.7743 mL 3.8716 mL 7.7432 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

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Volume (start)

V1

=
Concentration (final)

C2

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Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.8716 mL 19.3581 mL 38.7162 mL 96.7904 mL
5 mM 0.7743 mL 3.8716 mL 7.7432 mL 19.3581 mL
10 mM 0.3872 mL 1.9358 mL 3.8716 mL 9.6790 mL
15 mM 0.2581 mL 1.2905 mL 2.5811 mL 6.4527 mL
20 mM 0.1936 mL 0.9679 mL 1.9358 mL 4.8395 mL
25 mM 0.1549 mL 0.7743 mL 1.5486 mL 3.8716 mL
30 mM 0.1291 mL 0.6453 mL 1.2905 mL 3.2263 mL
40 mM 0.0968 mL 0.4840 mL 0.9679 mL 2.4198 mL
50 mM 0.0774 mL 0.3872 mL 0.7743 mL 1.9358 mL
60 mM 0.0645 mL 0.3226 mL 0.6453 mL 1.6132 mL
80 mM 0.0484 mL 0.2420 mL 0.4840 mL 1.2099 mL
100 mM 0.0387 mL 0.1936 mL 0.3872 mL 0.9679 mL
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4-Thiothymidine Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

4-Thiothymidine7236-57-9Nucleoside Antimetabolite/Analogindolent lymphoid malignanciesantitumorInhibitorinhibitorinhibit

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