7236-57-9
7236-57-9
Chemical Structure
4-Thiothymidine
- CAS No.: 7236-57-9
- Formula:C10H14N2O4S
- Molecular Weight:258.29
IUPAC Name: (R)-2-(tert-butylamino)-1-(7-ethylbenzofuran-2-yl)ethan-1-ol hydrochloride
InChIKey: AVKSPBJBGGHUMW-XLPZGREQSA-N
SMILES: OC[C@@H]1[C@@H](O)C[C@H](N2C(NC(C(C)=C2)=S)=O)O1
Biological Activity: 4-Thiothymidine is a thymidine analog with UVA photosensitizing properties. 4-Thiothymidine incorporates into the DNA of dividing cells via the thymidine kinase-mediated salvage pathway, replacing thymine and sensitizing cells to UVA irradiation, thereby inducing apoptosis. 4-Thiothymidine induces DNA damage upon UVA activation and inhibits DNA replication. 4-Thiothymidine is used in research related to non-melanoma skin malignancies such as squamous cell carcinoma[1][2][3].
| Cat. No. | 상품명 | Purity | 제품 설명 | Pricing | |||||||||||||||||||
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4-Thiothymidine | 99.69% | 4-Thiothymidine is a thymidine analog with UVA photosensitizing properties. 4-Thiothymidine incorporates into the DNA of dividing cells via the thymidine kinase-mediated salvage pathway, replacing thymine and sensitizing cells to UVA irradiation, thereby inducing apoptosis. 4-Thiothymidine induces DNA damage upon UVA activation and inhibits DNA replication. 4-Thiothymidine is used in research related to non-melanoma skin malignancies such as squamous cell carcinoma. | ||||||||||||||||||||
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5-Methyl-4-thiouridine | 5-Methyl-4-thiouridine is a purine nucleoside analogue. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc. | |||||||||||||||||||||
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1-(2-Deoxy-β-D-threo-pentofuranosyl)thymine | 99.68% | 1-(2-Deoxy-β-D-threo-pentofuranosyl)thymine is a thymidine analog. Analogs of this series have insertional activity towards replicated DNA. They can be used to label cells and track DNA synthesis. | ||||||||||||||||||||
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Telbivudine | 99.92% | Telbivudine (Epavudine), an orally active thymidine nucleoside analog, is a potent antiviral inhibitor of hepatitis B virus (HBV) replication. | ||||||||||||||||||||
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Thymidine (Standard) | 99.98% | Thymidine (Standard) is the analytical standard of Thymidine. This product is intended for research and analytical applications. Thymidine, a specific precursor of deoxyribonucleic acid, is used as a cell synchronizing agent. Thymidine is a DNA synthesis inhibitor that can arrest cell at G1/S boundary, prior to DNA replication. | ||||||||||||||||||||
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Thymidine-13C | 99.11% | Thymidine-13C is the 13C labeled Thymidine. Thymidine, a specific precursor of deoxyribonucleic acid, is used as a cell synchronizing agent. Thymidine is a DNA synthesis inhibitor that can arrest cell at G1/S boundary, prior to DNA replication | ||||||||||||||||||||
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Thymidine-13C-1 | Thymidine-13C-1 is the 13C labeled Thymidine. Thymidine, a specific precursor of deoxyribonucleic acid, is used as a cell synchronizing agent. Thymidine is a DNA synthesis inhibitor that can arrest cell at G1/S boundary, prior to DNA replication | |||||||||||||||||||||
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Thymidine-2′-13C | 98.12% | Thymidine-2′-13C is the 13C labeled Thymidine. Thymidine, a specific precursor of deoxyribonucleic acid, is used as a cell synchronizing agent. Thymidine is a DNA synthesis inhibitor that can arrest cell at G1/S boundary, prior to DNA replication. | ||||||||||||||||||||
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Thymidine-13C10,15N2 | 99.97% | Thymidine-13C10,15N2 is the 13C and 15N labeled Thymidine. Thymidine, a specific precursor of deoxyribonucleic acid, is used as a cell synchronizing agent. Thymidine is a DNA synthesis inhibitor that can arrest cell at G1/S boundary, prior to DNA replication. | ||||||||||||||||||||
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4-Thio-2’-deoxyuridine | 99.78% | 4-Thio-2’-deoxyuridine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc. | ||||||||||||||||||||
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Thymidine-13C5 | 99.85% | Thymidine-13C5 (DThyd-13C5; NSC 21548-13C5) is 13C-labeled Thymidine (HY-N1150). | ||||||||||||||||||||
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References
- [1]. Reelfs O, et al. Identification of potentially cytotoxic lesions induced by UVA photoactivation of DNA 4-thiothymidine in human cells. Nucleic acids research. 2011 Dec;39(22):9620-32.
- [2]. Gemenetzidis E, et al. Topical 4-thiothymidine is a viable photosensitiser for the photodynamic therapy of skin malignancies. The Journal of dermatological treatment. 2013 Jun;24(3):209-14.
- [3]. Pollum M, et al. 2,4-Dithiothymine as a potent UVA chemotherapeutic agent. Journal of the American Chemical Society. 2014 Dec 31;136(52):17930-3.
