(4S)-GLP-1 receptor agonist 14
Based on 1 Customer Validation
(4S)-GLP-1 receptor agonist 14 is a potent and orally active GLP-1 receptor agonist with an EC50 ≤ 20 nM. (4S)-GLP-1 receptor agonist 14 can be used for research on diabetes, obesity, metabolic diseases, cardiovascular diseases, liver diseases, nonalcoholic steatohepatitis (NASH), and other diseases associated with GLP-1 receptor.
For research use only. We do not sell to patients.
- Purity : 99.62%
- CAS No.: 2758659-09-3
- Formula: C48H46F2N10O5
- Molecular Weight:880.94
-
Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
-
Solvent & Solubility
- Protocols
- Purity & Documentation
- References
-
Help & FAQs
Biological Activity
Description
IC50 & Target
[1]|
GLP-1 receptor ≤20 nM (EC50) |
In Vitro
(4S)-GLP-1 receptor agonist 14 (compound 73) inhibits OATP1B1 with an IC50 < 1 μM in HEK293 cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.
Parmacokinetics
| Species | Dose | Route | Note | Cmax | AUC | F |
|---|---|---|---|---|---|---|
| Rat[1] | 5 mg/kg | p.o. | SD rats | 1700 ng/mL | 10193 ng·h/mL | 90 % |
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
-
CAS No. 2758659-09-3
-
Appearance Solid
-
Molecular Weight 880.94
-
Formula C48H46F2N10O5
-
Color Light yellow to light brown
-
SMILES
O=C(N1[C@H](C2=C(N3C(N(C4=CC=C(N(N=C5)C)C5=C4F)C=C3)=O)N(C6=CC(C7CC7)=C(C=C6)F)N=C2CC1)C)C8=C(N9C(C=C(C%10CC(C)(OCC%10)C)C=C9)=C8)C%11(C%12=NOC(N%12)=O)CC%11
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
In Vitro:
DMSO : 125 mg/mL (141.89 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Protocols
-
Research Protocol for Metabolic Diseases
AMP-activated protein kinase, AMPK, is a conserved cellular energy sensor that responds to reduced cellular energy status and coordinates metabolism by increasing ATP-generating catabolic pathways while suppressing ATP-consuming anabolic processes. In metabolic disease research, the AMPK pathway is experimentally relevant because it regulates hepatic lipid synthesis, fatty acid oxidation, glucose production, skeletal-muscle glucose disposal, mTORC1-linked biosynthesis, autophagy, mitochondrial homeostasis, and whole-body energy balance. The central pathway logic is that energy stress, metformin, exercise-like stimulation, or direct AMPK activators increase AMPKα Thr172 phosphorylation and downstream substrate phosphorylation, including ACC and RAPTOR. Phosphorylation of ACC suppresses lipogenesis and supports fatty acid oxidation, whereas phosphorylation of RAPTOR suppresses mTORC1 signaling and links cellular energy status to growth and protein synthesis control. The pathway is linked
Purity & Documentation
-
Data Sheet (278 KB)
-
SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
-
Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.1352 mL | 5.6758 mL | 11.3515 mL | 28.3788 mL |
| 5 mM | 0.2270 mL | 1.1352 mL | 2.2703 mL | 5.6758 mL | |
| 10 mM | 0.1135 mL | 0.5676 mL | 1.1352 mL | 2.8379 mL | |
| 15 mM | 0.0757 mL | 0.3784 mL | 0.7568 mL | 1.8919 mL | |
| 20 mM | 0.0568 mL | 0.2838 mL | 0.5676 mL | 1.4189 mL | |
| 25 mM | 0.0454 mL | 0.2270 mL | 0.4541 mL | 1.1352 mL | |
| 30 mM | 0.0378 mL | 0.1892 mL | 0.3784 mL | 0.9460 mL | |
| 40 mM | 0.0284 mL | 0.1419 mL | 0.2838 mL | 0.7095 mL | |
| 50 mM | 0.0227 mL | 0.1135 mL | 0.2270 mL | 0.5676 mL | |
| 60 mM | 0.0189 mL | 0.0946 mL | 0.1892 mL | 0.4730 mL | |
| 80 mM | 0.0142 mL | 0.0709 mL | 0.1419 mL | 0.3547 mL | |
| 100 mM | 0.0114 mL | 0.0568 mL | 0.1135 mL | 0.2838 mL |
(4S)-GLP-1 receptor agonist 14 Related Classifications
HY-164774 Related Classifications
Powered by Bioz