7α,15-Dihydroxydehydroabietic acid
7α,15-Dihydroxydehydroabietic acid is a natural abietane-type diterpenoid with antiangiogenic effects.
For research use only. We do not sell to patients.
- CAS No.: 155205-64-4
- Formula: C20H28O4
- Molecular Weight:332.43
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HEK293 | IC50 |
>100 μg/mL
Compound: 45
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Inhibition of TNF-alpha-induced NF-kappaB activity in human pNF-kappaB-luc-293 cells
Inhibition of TNF-alpha-induced NF-kappaB activity in human pNF-kappaB-luc-293 cells
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[PMID: 20022253] |
| LoVo | IC50 |
>25 μg/mL
Compound: 45
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Antiproliferative activity against human LoVo cells
Antiproliferative activity against human LoVo cells
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[PMID: 20022253] |
| QGY-7703 | IC50 |
>25 μg/mL
Compound: 45
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Antiproliferative activity against human QGY7703 cells
Antiproliferative activity against human QGY7703 cells
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[PMID: 20022253] |
| RAW264.7 | IC50 |
>100 μg/mL
Compound: 45
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Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced NO release
Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced NO release
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[PMID: 20022253] |
7α,15-Dihydroxydehydroabietic acid (3.125-100 μM; 24 hours) significantly decreases HUVEC cell viability[1].
7α,15-Dihydroxydehydroabietic acid (3.125-6.25 μM; 24 hours) significantly inhibits the promotion of angiogenesis in HUVECs. 7α,15-Dihydroxydehydroabietic acid inhibits angiogenesis through downregulation of the VEGF, p-Akt and p-ERK signaling pathways[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:Human umbilical vein endothelial cells (HUVECs)
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Concentration:3.125 μM, 6.25 μM, 12.5 μM, 25 μM, 50 μM, 100 μM
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Incubation Time:24 hours
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Result:Significantly decreased HUVEC cell viability.
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Cell Line:Human umbilical vein endothelial cells (HUVECs)
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Concentration:3.125 μM, 6.25 μM
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Incubation Time:24 hours
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Result:Human umbilical vein endothelial cells (HUVECs)[1] 3.125 μM, 6.25 μM 24 hours Showed downregulation of VEGF, p-Akt and p-ERK in HUVECs.
Chemical Information
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CAS No. 155205-64-4
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Molecular Weight 332.43
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Formula C20H28O4
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SMILES
O=C([C@]1(C)CCC[C@]2(C)C3=C([C@H](O)C[C@@]12[H])C=C(C(C)(O)C)C=C3)O
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Structure Classification
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
7α,15-Dihydroxydehydroabietic acid Related Classifications
HY-N7830 Related Classifications
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