1. Membrane Transporter/Ion Channel
    Neuronal Signaling
  2. GABA Receptor

DAA-1106 

Cat. No.: HY-19945 Purity: 99.70%
Handling Instructions

DAA1106 is a potent and selective ligand for peripheral benzodiazepine receptor (PBR), as a potent and selective agonist at the peripheral benzodiazepine receptor.

For research use only. We do not sell to patients.

DAA-1106 Chemical Structure

DAA-1106 Chemical Structure

CAS No. : 220551-92-8

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 365 In-stock
Estimated Time of Arrival: December 31
2 mg USD 192 In-stock
Estimated Time of Arrival: December 31
5 mg USD 420 In-stock
Estimated Time of Arrival: December 31
10 mg USD 600 In-stock
Estimated Time of Arrival: December 31
25 mg USD 1200 In-stock
Estimated Time of Arrival: December 31
50 mg USD 1800 In-stock
Estimated Time of Arrival: December 31
100 mg   Get quote  
200 mg   Get quote  

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Customer Review

  • Biological Activity

  • Technical Information

  • Purity & Documentation

  • References

Description

DAA1106 is a potent and selective ligand for peripheral benzodiazepine receptor (PBR), as a potent and selective agonist at the peripheral benzodiazepine receptor. Target:PBR in vitro: DAA1106 binding to PBR was significantly increased in widespread areas in MCI subjects when compared to healthy controls.[1] DAA-1106 is a drug which acts as a potent and selective agonist at the peripheral benzodiazepine receptor, also known as the mitochondrial 18 kDa translocator protein or TSPO, but with no affinity at the GABAA receptor. [2] in vivo: DAA-1106 has anxiolytic effects in animal studies. DAA-1106 has a sub-nanomolar binding affinity (Ki) of 0.28nM, and has been used extensively in its 3H or 11C radiolabelled form to map TSPO in the body and brain, which has proved especially helpful in monitoring the progress of neurodegenerative diseases such as Alzheimer's disease. [2]

Solvent & Solubility
In Vitro: 

DMSO : ≥ 35 mg/mL (88.51 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.5290 mL 12.6448 mL 25.2896 mL
5 mM 0.5058 mL 2.5290 mL 5.0579 mL
10 mM 0.2529 mL 1.2645 mL 2.5290 mL
*Please refer to the solubility information to select the appropriate solvent.
References
Molecular Weight

395.42

Formula

C₂₃H₂₂FNO₄

CAS No.

220551-92-8

SMILES

CC(N(CC1=CC(OC)=CC=C1OC)C2=CC(F)=CC=C2OC3=CC=CC=C3)=O

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Shipping

Room temperature in continental US; may vary elsewhere

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Product Name:
DAA-1106
Cat. No.:
HY-19945
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DAA-1106

Cat. No.: HY-19945