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Dehydroisoandrosterone 3-acetate (Synonyms: Dehydroepiandrosterone 3-acetate; DHEA acetate)

Cat. No.: HY-B1405 Purity: >98.0%
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Dehydroepiandrosterone 3-acetate is a testosterone/estrogen precursor and known modulator of vertebrate aggression.

For research use only. We do not sell to patients.

Dehydroisoandrosterone 3-acetate Chemical Structure

Dehydroisoandrosterone 3-acetate Chemical Structure

CAS No. : 853-23-6

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Based on 1 publication(s) in Google Scholar

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Description

Dehydroepiandrosterone 3-acetate is a testosterone/estrogen precursor and known modulator of vertebrate aggression.

In Vivo

Dehydroisoandrosterone implants increases aggression in a laboratory-based simulated territorial intrusion. Brains of Dehydroisoandrosterone-implanted birds show higher aromatase mRNA expression in the preoptic area (POA) and higher androgen receptor mRNA expression in the periventricular nucleus of the medial striatum (pvMSt) and ventromedial nucleus of the hypothalamus (VMH). The Dehydroisoandrosterone-induced increases in aromatase expression in the POA and androgen receptor expression in the pvMSt are consistent with previously reported seasonal increases in these markers associated with naturally elevated Dehydroisoandrosterone levels[1]. Dehydroisoandrosterone supplementation (10.2 mg/kg) alone significantly increases mice body weight (BW), muscle weight, testosterone level, and glycogen contents (liver and muscle) when compared with SC group[2].

Molecular Weight

330.46

Formula

C₂₁H₃₀O₃

CAS No.

853-23-6

SMILES
Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 14.29 mg/mL (43.24 mM; Need ultrasonic)

H2O : < 0.1 mg/mL (insoluble)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.0261 mL 15.1304 mL 30.2609 mL
5 mM 0.6052 mL 3.0261 mL 6.0522 mL
10 mM 0.3026 mL 1.5130 mL 3.0261 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 1.43 mg/mL (4.33 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 1.43 mg/mL (4.33 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 1.43 mg/mL (4.33 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
Animal Administration
[2]

The oral gavage treated with Dehydroisoandrosterone once a day for 6-week at 10.2 mg/day. SC group receives the same volume of distilled water equivalent to body weight. The Dehydroisoandrosterone supplementation in WBV+Dehydroisoandrosterone group is complete WBV training after 30 min. The recommended use of Dehydroisoandrosterone for humans is about 50 mg per one intake with a normal diet and exercise program. The mouse Dehydroisoandrosterone dose (10.2 mg/kg) used in this study is converted from a human equivalent dose on the basis of body surface area by the following formula from the US Food and Drug Administration 16: assuming a human weight of 60 kg, the human equivalent dose of 50 mg/60 kg (0.83 mg/kg)=0.83 × 12.3=a mouse dose of 10.2 mg/kg; the conversion coefficient 12.3 is used to account for differences in body surface area between a mouse and a human.

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

References

Purity: >98.0%

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Keywords:

Dehydroisoandrosterone 3-acetateDehydroepiandrosterone 3-acetateDHEAAndrogen ReceptorInhibitorinhibitorinhibit

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Dehydroisoandrosterone 3-acetate
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