(S,R,S)-AHPC-PEG4-NH2
Based on 2 publication(s) in Google Scholar
(S,R,S)-AHPC-PEG4-NH2 is a synthesized E3 ligase ligand-linker conjugate that incorporates the (S,R,S)-AHPC based VHL ligand and 4-unit PEG linker used in PROTAC technology.
Nos produits utilisent uniquement pour la recherche. Nous ne vendons pas aux patients.
- Pureté : 95.62%
- CAS No.: 2010159-57-4
- Formule: C32H49N5O8S
- Masse moléculaire:663.83
-
Stockage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 2 years , -20°C, 1 year
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Activité biologique
-
Chemical Information
-
Solvant et solubilité
- Pureté et documentation
- Références
-
Help & FAQs
-
HY-103602
(S,R,S)-AHPC-PEG3-NH2 hydrochlorideE3 Ligase Ligand-Linker Conjugate -
HY-103603
(S,R,S)-AHPC-PEG2-NH2 hydrochlorideE3 ligase ligand-linker conjugate -
HY-133487B
(S,R,S)-AHPC-C8-NH2E3 Ligase Ligand-Linker Conjugate -
HY-103603A
(S,R,S)-AHPC-PEG2-NH2E3 ligase ligand-linker conjugate -
HY-136183
(S,R,S)-AHPC-phenol-alkylC6-amine dihydrochlorideE3 Ligase Ligand-Linker Conjugate -
HY-135045
(S,R,S)-AHPC-C4-COOHE3 Ligase Ligand-Linker Conjugate -
HY-139218
(S,R,S)-AHPC-Me-C6-NH2E3 Ligase Ligand-Linker Conjugates -
HY-136006B
(S,R,S)-AHPC-C6-NH2E3 Ligase Ligand-Linker Conjugates -
HY-103611
Thalidomide-O-amido-PEG3-C2-NH2 TFAE3 ligase ligand-linker conjugate -
HY-103604AR
(S,R,S)-AHPC-PEG4-NH2 (Standard)Reference Standard -
HY-136184
(S,R,S)-AHPC-phenol-C4-NH2 dihydrochlorideE3 Ligase Ligand-Linker Conjugates -
HY-138550A
(S,R,S)-AHPC-3-methylbutanyl acetate-methanesulfonothioate-PEG3-NH2 TFAE3 Ligase Ligand-Linker Conjugate
Publications Citing Use of MedChemExpress (MCE) (S,R,S)-AHPC-PEG4-NH2
MoreVoir tous les produits spécifiques à Isoform E3 Ligase Ligand-Linker Conjugates
More
Activité biologique
Description
IC50 & Target
[1]|
VHL |
In Vitro
Chemical Information
-
CAS No. 2010159-57-4
-
Appearance Solid
-
Masse moléculaire 663.83
-
Formule C32H49N5O8S
-
Color White to off-white
-
SMILES
O=C(N[C@@H](C(C)(C)C)C(N(C[C@H](O)C1)[C@@H]1C(NCC2=CC=C(C(SC=N3)=C3C)C=C2)=O)=O)COCCOCCOCCOCCN
-
Synonyms
VH032-PEG4-NH2; VHL Ligand-Linker Conjugates 4 ; E3 ligase Ligand-Linker Conjugates 7 Free Base
-
Livraison
Room temperature in continental US; may vary elsewhere.
-
Stockage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 2 years -20°C 1 year
Publications (2)
-
Journal Impact Factor
-
Most Recent
-
ACS Omega
Development of BODIPY FL VH032 as a High-Affinity and Selective von Hippel-Lindau E3 Ligase Fluorescent Probe and Its Application in a Time-Resolved Fluorescence Resonance Energy-Transfer Assay. [Abstract]2020 Dec 29;6(1):680-695. PMID: 33458521 -
Bioconjug Chem
Development of BODIPY FL Thalidomide As a High-Affinity Fluorescent Probe for Cereblon in a Time-Resolved Fluorescence Resonance Energy Transfer Assay. [Abstract]2020 Nov 18;31(11):2564-2575. PMID: 33070611
Solvant et solubilité
In Vitro:
DMSO : 170 mg/mL (256.09 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Pureté et documentation
-
Fiche technique (271 KB)
-
SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
-
Instruction de manipulation (2659 KB)
Références
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.5064 mL | 7.5320 mL | 15.0641 mL | 37.6602 mL |
| 5 mM | 0.3013 mL | 1.5064 mL | 3.0128 mL | 7.5320 mL | |
| 10 mM | 0.1506 mL | 0.7532 mL | 1.5064 mL | 3.7660 mL | |
| 15 mM | 0.1004 mL | 0.5021 mL | 1.0043 mL | 2.5107 mL | |
| 20 mM | 0.0753 mL | 0.3766 mL | 0.7532 mL | 1.8830 mL | |
| 25 mM | 0.0603 mL | 0.3013 mL | 0.6026 mL | 1.5064 mL | |
| 30 mM | 0.0502 mL | 0.2511 mL | 0.5021 mL | 1.2553 mL | |
| 40 mM | 0.0377 mL | 0.1883 mL | 0.3766 mL | 0.9415 mL | |
| 50 mM | 0.0301 mL | 0.1506 mL | 0.3013 mL | 0.7532 mL | |
| 60 mM | 0.0251 mL | 0.1255 mL | 0.2511 mL | 0.6277 mL | |
| 80 mM | 0.0188 mL | 0.0942 mL | 0.1883 mL | 0.4708 mL | |
| 100 mM | 0.0151 mL | 0.0753 mL | 0.1506 mL | 0.3766 mL |
(S,R,S)-AHPC-PEG4-NH2 Related Classifications
HY-103604A Related Classifications
Powered by Bioz