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Cat. No.: HY-U00263

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LY210073

LY210073 is a Leukotriene B₄ (LTB₄) receptor antagonist with an IC₅₀ of 6.2 nM.

For research use only. We do not sell to patients.

CAS No.: 148291-65-0
Formula: C₃₀H₂₈O₈
Molecular Weight:516.54

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (264 KB)

LY210073 Chemical Structure

CAS No.: 148291-65-0

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- Cellular Effect
- In Vitro
Chemical Information
Protocols (1)
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

LY210073 is a Leukotriene B₄ (LTB₄) receptor antagonist with an IC₅₀ of 6.2 nM.

IC₅₀ & Target

LTB₄

6.2 nM (IC₅₀)

All Leukotriene Receptor Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
Neutrophil	IC₅₀	1599 nM Compound: 32 (LY-210073)	Inhibition of luminol-dependent chemiluminescence induced by stimulating the neutrophil cells with FMLP (N-formyl-L-methionyl-L-leucyl-l-phenylalanine) Inhibition of luminol-dependent chemiluminescence induced by stimulating the neutrophil cells with FMLP (N-formyl-L-methionyl-L-leucyl-l-phenylalanine)	[PMID: 8389876]
Neutrophil	IC₅₀	55 nM Compound: 32 (LY-210073)	Inhibition of luminol-dependent chemiluminescence induced by stimulating the neutrophil cells with LTB4. Inhibition of luminol-dependent chemiluminescence induced by stimulating the neutrophil cells with LTB4.	[PMID: 8389876]

In Vitro

LY210073 is a Leukotriene B₄ (LTB₄) receptor antagonist with an IC₅₀ of 6.2±0.1 nM. LY2100731 (Compound 32) appears to be one of the strongest inhibitors of LTB₄ receptor binding reported so far^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.

Chemical Information

CAS No. 148291-65-0
Molecular Weight 516.54
Formula C₃₀H₂₈O₈
SMILES

O=C(O)CCC1=C(OCCCC/C=C/C2=CC=C(OC)C=C2)C=CC(C3=O)=C1OC4=C3C=C(C(O)=O)C=C4
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Protocols

All Cell Biology

Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (264 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Jackson WT, et al. Design, synthesis, and pharmacological evaluation of potent xanthone dicarboxylic acid leukotriene B4 receptor antagonists. J Med Chem. 1993 Jun 11;36(12):1726-34.

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

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100 mg

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