Indacrinone
Based on 1 Customer Validation
Indacrinone (MK196) is an investigational diuretic which has pronounced saluretic activity in the rat and dog as well as both uricosuric and saluretic activity in the chimpanzee.
For research use only. We do not sell to patients.
- Purity: 99.89%
- CAS No.: 56049-88-8
- Formula: C18H14Cl2O4
- Molecular Weight:365.21
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Storage:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Protocol
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 56049-88-8
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Appearance Solid
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Molecular Weight 365.21
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Formula C18H14Cl2O4
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Color White to light yellow
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SMILES
O=C(O)COC1=CC2=C(C(C(C3=CC=CC=C3)(C)C2)=O)C(Cl)=C1Cl
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Synonyms
MK-196; Indacrynic acid
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : 125 mg/mL (342.27 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Protocol
Sixteen mice are administered Indacrinone-14C. Four mice, 2 male and 2 female, are dosed orally with 10 mg/kg of drug and four additional mice (2M, 2F) are given the drug i.v. via the tail vein. In similar fashion eight additional mice are dosed with 1 mg/kg Indacrinone-14C either orally or intravenously.The animals are housed in separate metabolism cages, 2 mice of same sex per cage.The animals are fasted overnight prior to drug administration. Urine and feces are collected for the 24-hour period post drug. Animals are allowed free access to water. Urine specimens are also obtained from mice which receive Indacrinone orally at doses of 10 and 20 mg/kg/day for 9 days. On day 9 the mice are dosed and placed in metabolism cages; two cages are used per sex per group. Urine is collected during the five-hour period post last dose. A total of nineteen mice are dosed with 10 mg/kg and 18 mice are dosed with 20 mg/kg of drug[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Purity & Documentation
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Data Sheet (271 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.7382 mL | 13.6908 mL | 27.3815 mL | 68.4538 mL |
| 5 mM | 0.5476 mL | 2.7382 mL | 5.4763 mL | 13.6908 mL | |
| 10 mM | 0.2738 mL | 1.3691 mL | 2.7382 mL | 6.8454 mL | |
| 15 mM | 0.1825 mL | 0.9127 mL | 1.8254 mL | 4.5636 mL | |
| 20 mM | 0.1369 mL | 0.6845 mL | 1.3691 mL | 3.4227 mL | |
| 25 mM | 0.1095 mL | 0.5476 mL | 1.0953 mL | 2.7382 mL | |
| 30 mM | 0.0913 mL | 0.4564 mL | 0.9127 mL | 2.2818 mL | |
| 40 mM | 0.0685 mL | 0.3423 mL | 0.6845 mL | 1.7113 mL | |
| 50 mM | 0.0548 mL | 0.2738 mL | 0.5476 mL | 1.3691 mL | |
| 60 mM | 0.0456 mL | 0.2282 mL | 0.4564 mL | 1.1409 mL | |
| 80 mM | 0.0342 mL | 0.1711 mL | 0.3423 mL | 0.8557 mL | |
| 100 mM | 0.0274 mL | 0.1369 mL | 0.2738 mL | 0.6845 mL |
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