Infection

NHS-PEG2000-Mannose is an NHS-PEG-Mannose containing PEG2000. NHS-PEG-Mannose is a D-mannose derivative and linker. NHS-PEG-Mannose can bind to phage coat proteins via amino-carboxyl reaction to form mannose-modified phage (Man-phage).

Dowicil 200 (Quaternium-15) is a skin toxin and allergen that inhibits the growth of Pinctada fucata cells. Dowicil 200 has antimicrobial activity and is more potent against fungi and molds than against fungi.

Tropone (Cycloheptatrienone) is a non-benzenoid aromatic natural product that acts as a membrane reverse transporter and metal chelator. Tropone disrupts the proton motive force by affecting the transmembrane proton gradient and functions as a quorum sensing signal through LuxR-type transcriptional regulators. Tropone exhibits broad-spectrum antibiotic, anticancer, algicidal, and probiotic activities. As a virulence factor toxic to rice seedlings, Tropone promotes biofilm formation in Burkholderia plantarii and induces neurotoxicity involving mitochondrial and cytoskeletal damage, increased Ca²⁺ influx, and oxidative stress. Tropone is used in the study of bacterial infections.

Adipic acid-d₈ (Hexanedioic acid-d₈) is the deuterium labeled Adipic acid (HY-W017522). Adipic acid (Hexanedioic acid) is an orally active compound with anti-HSV-1 activity. Adipic acid has low toxicity and can be used as a food additive and a gelling agent. Adipic acid can also be used in the synthesis of lubricants, artificial resins, plastics, etc.

Alpelisib (BYL-719) (Standard) is the analytical standard of Alpelisib (HY-15244). This product is intended for research and analytical applications. Alpelisib (BYL-719) is an orally active PI3Kα-selective inhibitor that blocks the conversion of PIP2 to PIP3, thereby inhibiting pathways including PI3K/AKT/mTOR, MAPK/ERK, Notch and JAK-STAT. Alpelisib also induces apoptosis, G0/G1 phase arrest and senescence; it significantly inhibits the proliferation, self-renewal, stemness and epithelial-mesenchymal transition (EMT) of tumor cells, reduces cancer stem cell populations and decreases the expression of stem cell markers. Alpelisib not only enhances the sensitivity to Eribulin (HY-13442) and exerts a synergistic effect with Paclitaxel (HY-B0015), but may also induce drug resistance by upregulating the SGK3/GSK3β/β-catenin signaling pathway. Alpelisib can be applied to research related to breast cancer, gastric cancer and lipomas associated with PTEN hamartoma tumor syndrome.

(-)-Lupinine is an alkaloid and membrane fusion inhibitor. (-)-Lupinine does not affect the synthesis of proinflammatory cytokines during the host response to Serratia proteamaculans infection. (-)-Lupinine can enhance the expression of the bacterial surface protein OmpX. (-)-Lupinine can be used for research on bacterial infections.

Z-Arg-Leu-Arg-Gly-Gly-AMC acetate is a peptide substrate for SARS-CoV PL^pro.

T3SS-IN-2 (Compound 2h) is a type three secretion system (T3SS) inhibitor. T3SS-IN-2 can be used for bacterial infection research.

Cyclosporin C is a fungal metabolite that has been found in T. inflatum and has diverse biological activities, including antifungal, antiviral, and immunosuppressant properties. Cyclosporin C shows no activity against bacteria or yeasts.

2'-Hydroxy-4'-methylacetophenone is an acetophenone (HY-Y0989) derivative and acaricide that can be isolated from the roots of Angelica koreana. 2'-Hydroxy-4'-methylacetophenone exhibits toxicity against mites. It serves as a starting material for the synthesis of flavonoid derivatives. 2'-Hydroxy-4'-methylacetophenone can be used in studies related to infestations of house dust mites and stored food mites.

SM-102-d₄ is the deuterium labeled SM-102 (HY-134541). SM-102 is an amino cationic lipid useful in the formation of lipid nanoparticles (LNPs). SM-102 has higher transfection efficiency. SM-102 plays an important role in the effectiveness of lipid nanoparticles (LNPs) in delivering mRNA therapeutics and vaccines.

Ciprofloxacin-¹³C₃,¹⁵N (Bay-09867-¹³C₃,¹⁵N) monohydrochloride is ¹³C- and ¹⁵N-labeled Ciprofloxacin (monohydrochloride) (HY-B0356A).

3-Amino-5-hydroxybenzoic acid is a biosynthetic precursor of the mC7N unit of ansamycin antibiotics, including ansatrienin A and geldanamycin, as well as the antitumor antibiotic mitomycin C. 3-Amino-5-hydroxybenzoic acid may be an early intermediate in the shikimic acid pathway from glucose.

Dimethyl fumarate (Standard) is the analytical standard of Dimethyl fumarate. This product is intended for research and analytical applications. Dimethyl fumarate (DMF) is an orally active and brain-penetrant Nrf2 activator and induces upregulation of antioxidant gene expression. Dimethyl fumarate induces necroptosis in colon cancer cells through GSH depletion/ROS increase/MAPKs activation pathway, and also induces cell autophagy. Dimethyl fumarate can be used for multiple sclerosis research.

1-Docosanol (Behenyl alcohol) is a saturated fatty alcohol with reported inhibitory activity against lipid-enveloped viruses, including herpes simplex virus (HSV).

T-705RMP (ammonium) is the ammonium form of T-705RMP. T-705RMP (ammonium)’s the inhibition of IMP dehydrogenase (IMPDH) activity is weak .

Ronidazole (Standard) is the analytical standard of Ronidazole. This product is intended for research and analytical applications. Ronidazole is a potent and orally active antiprotozoal and anti-microbial agent. Ronidazole acts as a veterinary agent against Tritrichomonas foetus?in cats models. Ronidazole can be used the research of forhistomoniasis?and?swine?dysentery.

Retusin (Quercetin-3,3',4',7-tetramethylether) is a tyrosinase inhibitor, with IC₅₀ values of 50.9 μM and 51.8 μM against mushroom and intracellular tyrosinase, respectively. Retusin also acts as a free radical scavenger, melanogenesis inhibitor, anti-apoptosis agent, neuroprotective agent, antiemetic, antifungal agent, and antiviral agent. Retusin scavenges ABTS•⁺ and DPPH• free radicals. Retusin can be used in studies related to hyperpigmentation, vomiting, Aspergillus niger infection, and COVID-19 infection.

Montmorillonite is a calcium-based 2:1 layered silicate clay mineral with excellent adsorption capacity, which can adsorb and immobilize a variety of substances, such as organic compounds, metal ions, and bacteria. Montmorillonite can serve as a nanoparticle carrier for research on functional nanocomposites for multiple scenarios, such as biomedical applications and food additives. Montmorillonite is also applicable to research related to wastewater treatment.

3-Iodobenzoic acid is a Monoiodobenzoic acid. 3-Iodobenzoic acid inhibits the ADV7 virus. 3-Iodobenzoic acid can be used in the study of respiratory infections caused by ADV7.