Metabolic Disease

N,N,O-Tridesmethylvenlafaxine is an endogenous metabolite.

Glycyrin is a PPAR-γ ligand of licorice. Glycyrin can decrease the blood glucose levels of genetically diabetic mice. Glycyrin also shows antibacterial activity.

Amylin (IAPP), feline TFA is a 37-amino acid polypeptide from feline. Amylin (IAPP), feline TFA is one of the major secretory products of β-cells of the pancreatic islets. Amylin (IAPP), feline TFA is a regulatory peptide, which inhibits insulin and glucagon secretion.

BMS-819881 is a melaninconcentrating hormone receptor 1 (MCHR1) antagonist, which binds rat MCHR1 with a K_i of 7 nM. BMS-819881 also is selective and potent for CYP3A4 activity with an EC₅₀ of 13 μM.

L-Alanine-1-¹³C is the ¹³C-labeled L-Alanine. L-Alanine is a non-essential amino acid, involved in sugar and acid metabolism, increases immunity, and provides energy for muscle tissue, brain, and central nervous system.

N,N-Dimethylamidino Urea (N-Carbonylguanidine) is an intermediate in the electrochemical oxidation of Metformin (HY-B0627). Metformin can be used in the study of type 2 diabetes. N,N-Dimethylamidino Urea can be used as a marker to study the metabolic pathway of metformin in vivo.

Cimigenoside is an active compound from genus Cimicifuga.

GW856464 is an antagonist for MCHR1. GW856464 can be studied in research for cardiovascular diseases and obesity.

Epitheaflagallin 3-O-gallate is a minor polyphenol in black tea. Epitheaflagallin 3-O-gallate exhibits versatile physiological functions in vivo and in vitro, including antioxidative activity, pancreatic lipase inhibition, Streptococcus sorbinusglycosyltransferase inhibition, and an inhibiting effect on the activity of matrix metalloprotease-1 and -3 and their synthesis by human gingival fibroblasts.

Leucine Aminopeptidase(microsomal), Porcine (EC 3.4.11.2) is an enzyme that preferentially catalyze the hydrolysis of leucine residues at the N-terminus of peptides and proteins.

Ethyl 3,4,5-trimethoxybenzoate is a melanogenesis inhibitor. Ethyl 3,4,5-trimethoxybenzoate does not directly target tyrosinase activity, but inhibits melanin synthesis in a dose-dependent manner by downregulating α-MSH (HY-P0252)-induced tyrosinase protein expression and scavenging ROS. Ethyl 3,4,5-trimethoxybenzoate scavenges DPPH free radicals. Ethyl 3,4,5-trimethoxybenzoate can be used in the research of hyperpigmentation.

RXFP2 agonist 2 is a selective, orally active and allosteric RXFP2 agonist with an EC₅₀ value of 0.38 μM. RXFP2 agonist 2 induces osteoblast mineralization. RXFP2 agonist 2 increases bone formation in female mice. RXFP2 agonist 2 has the potential for the research of osteoporosis.

N-(3-Methoxybenzyl)oleamide (MAC 18:1) is an individual macamide. N-(3-Methoxybenzyl)oleamide can be isolated from Lepidium meyenii (maca).

LP-371-p is a lipid that can specifically and efficiently deliver oligonucleotide compounds to the fat tissues in the body (especially fat cells). LP-371-p can be used in research on diseases related to fat, such as obesity and type 2 diabetes.

4-Hydroxy nonenal glutathione (4-HNE-GSH) TFA is the primary metabolite of 4-Hydroxy-2-nonenal. 4-Hydroxy nonenal glutathionea TFA is a marker of oxidative stress in rat liver and hepatocytes. 4-Hydroxy nonenal glutathione TFA efficiently prevents formation of DNA adducts with 4-Hydroxy-2-nonenal in human cells.

N4-Acetylcytidine triphosphate is efficiently used as a substrate in T7 Polymerase-catalyzed in vitro transcription and can be incorporated into multiple templates.

Tiaprost is a prostaglandin F_2α (PGF_2α) analogue.

BIIE-0246 hydrochloride (AR-H 053591 hydrochloride) is a potent and selective NPY2R (neuropeptide Y receptor 2) antagonist with an IC₅₀ value of 15 nM for rat [¹²⁵I]PYY_3-36. BIIE-0246 hydrochloride decreases the expression of p-AKT S473, P-p44/42 MAPK under the NPY-stimulated. BIIE-0246 hydrochloride reduces albuminuria in ADR nephropathy.

Homovanillic acid-d₂ (Vanilacetic acid-d₂) is the deuterium labeled Homovanillic acid (HY-N0384). Homovanillic acid (Vanilacetic acid) is a dopamine metabolite found to be associated with aromatic L-amino acid decarboxylase deficiency, celiac disease, growth hormone deficiency, and sepiapterin reductase deficiency.

Nitisinone (Standard) is the analytical standard of Nitisinone. This product is intended for research and analytical applications. Nitisinone is an orally active, competitive and reversible 4-hydroxyphenylpyruvate dioxygenase (4-HPPD) inhibitor with an IC₅₀ of 173 nM. Nitisinone promotes tyrosine accumulation in a dose-dependent manner. nitisinone can be used in studies of hereditary tyrosinemia type 1 (HT-1) (a rare genetic disorder) and albinism.