Metabolic Disease

Oleic acid triethanolamine (9-cis-Octadecenoic acid triethanolamine) is the most common monounsaturated fatty acid found in human adipocytes and other tissues. Oleic acid triethanolamine is a Na⁺/K⁺ ATPase activator.

8-Hydroxyoctadecanoic acid is an ester product.

1-Docosapentaenoin-2-palmitin-3-olein is an acylglycerol.

VULM 1457 (Standard) is the analytical standard of VULM 1457 (HY-107571). This product is intended for research and analytical applications. VULM 1457 is a potent inhibitor of cholesterol acyltransferase (acyl-CoA). VULM1457 significantly reduces production and secretion of adrenomedullin (AM) and down-regulates AM receptors on human hepatoblastic cells. VULM 1457 has remarkable hypolipidaemic activity and improves the overall myocardial ischaemia-reperfusion injury outcomes. VULM 1457 has the potential for the research of diabetes mellitus and hypercholesterolaemia.

C18(Plasm)-18:1 PE is a lycerophospholipid.

Linolenyl palmitate is an ester product.

5-Formyl-dCTP is a monomeric raw material that can be used for nucleic acid synthesis.

Rimonabant (Standard) is the analytical standard of Rimonabant. This product is intended for research and analytical applications. Rimonabant (SR141716) is a highly potent, brain penetrated and selective central cannabinoid receptor (CB1) antagonist with a Ki of 1.8 nM. Rimonabant (SR141716) also inhibits Mycobacterial membrane protein Large 3 (MMPL3).

N-Oleoyl sphinganine (C18:1-Dihydro-ceramide) is an ester product.

1,3-Dipentanoin is a glycerolipid.

11-S-Hydroxyeicosatetraenoic acid (11(S)-Hydroxy-5(Z),8(Z),12(E),14(Z)-eicosatetraenoic acid) is an ester product.

1,2-Olein-3-acetyl is an acylglycerol.

Fructo-oligosaccharide DP12/GF11 belongs to fructooligosaccharides (FOS) with degree of polymerization (DP=12). Fructo-oligosaccharides (FOS) are composed of 11 fructose units linked by (2→1)-β-glycosidic bonds and having a single D-glucosyl unit at the non-reducing end.

Heptadecyl methane sulfonate (1-Heptadecanol, methanesulfonate) is an ester product.

DMTr-S-5-C-Me-2'-F-dA(Bz)-3'-CE-phosphoramidite is a monomeric raw material that can be used for nucleic acid synthesis.

TGR5 Receptor Agonist (Standard) is the analytical standard of TGR5 Receptor Agonist. This product is intended for research and analytical applications. TGR5 Receptor Agonist (CCDC), a potent Takeda G protein-coupled receptor 5 (TGR5; GPCR19) agonist, shows improved potency in the U2-OS cells and melanophore cells with pEC50s of 6.8 and 7.5, respectively. TGR5 Receptor Agonist can induce peripheral and central hypersensitivity to bladder distension in mice, and increase intracellular Ca2+ concentration. TGR5 Receptor Agonist can also reduces food intake and improves insulin responsiveness, in diet-induced obese mice. TGR5 Receptor Agonist can be used to research diabetes, bladder hypersensitivity and anti-obesity.

Cinitapride (Standard) is the analytical standard of Cinitapride. This product is intended for research and analytical applications. Cinitapride is a nonselective 5-HT1 and 5-HT4 receptors agonist and a 5-HT2 and D2 antagonist. Cinitapride can be used in functional dyspepsia (FD) and gastroesophageal reflux disease (GERD) research.

rac-Dihydrophytol is an intermediate in the biosynthesis of Phytanic acid (HY-113067).

Azemiglitazone (Standard) is the analytical standard of Azemiglitazone (HY-108022). This product is intended for research and analytical applications. Azemiglitazone (MSDC-0602) is an orally active thiazolidinedione (TZD) -like molecule, which binds to PPARγ with low binding and activating affinity. Azemiglitazone inhibits mitochondrial pyruvate carrier (MPC), which inhibits Alzheimer’s disease and diminishes nonalcoholic steatohepatitis (NASH) caused liver injury.

KHK-IN-8 is a selective KHK inhibitor, with an IC₅₀ of 13.0 nM against hKHK-C and an IC₅₀ of 22.7 nM against hKHK-A. KHK-IN-8 is applicable to research on non-alcoholic steatohepatitis, type 2 diabetes and obesity.