Metabolic Disease

GPR40/FFAR1 modulator 1 (Standard) is the analytical standard of GPR40/FFAR1 modulator 1 (HY-111763). This product is intended for research and analytical applications. GPR40/FFAR1 modulator 1 is an agonist and an allosteric modulator for Gq-coupled free fatty acid receptor 1 (GPR40/FFAR1).

12-Pentacosanone (pentacosan-12-one) is an ester product.

Hispidin (Standard) is the analytical standard of Hispidin. This product is intended for research and analytical applications. Hispidin, a PKC inhibitor and a phenolic compound can be found in Phellinus linteus, has been shown to possess strong anti-oxidant, anti-cancer, anti-diabetic, and anti-dementia properties[1][2][3][4][5][6][7].

Compound amino acids solution (18AA) is a nutritional supplement solution containing 18 essential and non-essential amino acids, which can improve the nutritional status.

(4Z)-4-Decenoic acid is a fatty acid.

DGAT-1 inhibitor 2 (Standard) is the analytical standard of DGAT-1 inhibitor 2 (HY-50670). This product is intended for research and analytical applications. DGAT-1 inhibitor 2 is an orally active DGAT-1 inhibitor with IC₅₀ values of 15 nM and 9 nM for human DGAT-1 and rat DGAT-1, respectively. DGAT-1 inhibitor 2 increases ROS concentration, GRP78, and PERK protein abundance. DGAT-1 inhibitor 2 increases SREBF1, CPT1A, and MTTP mRNA in fatty acid-treated cells. DGAT-1 inhibitor 2 improves obesity.

MK6-83 (Standard) is the analytical standard of MK6-83 (HY-110238). This product is intended for research and analytical applications. MK6-83 is a new candidate agonist of TRPML1 with an improved efficacy and potency. MK6-83 has the potential for Mucolipidosis type IV study.

Sobetirome (Standard) is the analytical standard of Sobetirome. This product is intended for research and analytical applications. Sobetirome (GC-1) is a thyroid hormone receptor β (TRβ)-specific agonist which bind selectively to TRβ-1 with an EC50 of 0.16 μM.

10(Z),13(Z)-Nonadecadienoyl chloride is an ester product.

3'-O-TBDMS-2'-dC(Bz) is a monomeric raw material that can be used for nucleic acid synthesis.

Asimadoline hydrochloride (Standard) (EMD-61753 hydrochloride (Standard)) is the analytical standard of Asimadoline (hydrochloride) (HY-107384A). This product is intended for research and analytical applications. Asimadoline (EMD-61753) hydrochloride is an orally active, selective and peripherally active κ-opioid agonist with IC₅₀s of 5.6 nM (guinea pig) and 1.2 nM (human recombinant). Asimadoline hydrochloride has low permeability across the blood brain barrier and has peripheral anti-inflammatory actions. Asimadoline hydrochloride ameliorates allodynia in diabetic rats and has the potential for irritable bowel syndrome (IBS).

1,3-Didocosanoyl-2-oleoyl glycerol is a triacylglycerol that contains Docosanoic acid (HY-W013049) at the sn-1 and sn-3 positions and Oleic acid (HY-N1446) at the sn-2 position.

MRL-650 (CB1 inverse agonist 1), a chemical probe, is a highly potent, orally active, and specific inverse agonist of CB1 receptor with IC₅₀s of 7.5 nM and 4100 nM for CB1 and CB2 receptors, respectively. Anorexigenic effects.

Eicosane (Standard) is the analytical standard of Eicosane. This product is intended for research and analytical applications. Eicosane is an ester product.

Muramyl dipeptide (Standard) is the analytical standard of Muramyl dipeptide (HY-127090). This product is intended for research and analytical applications. Muramyl dipeptide (MDP) is a synthetic immunoreactive peptide, consisting of N-acetyl muramic acid attached to a short amino acid chain of L-Ala-D-isoGln. Muramyl dipeptide is an inducer of bone formation through induction of Runx2. Muramyl dipeptide directly enhances osteoblast differentiation by up-regulating Runx2 gene expression through MAPK pathways. Muramyl dipeptide is a NLRP1 agonist.

Lauryl linoleate is an ester product.

Isovaleryl-CoA sodium is a branched-chain acyl-CoA and an inhibitor of succinate-CoA ligase (SCL), with an IC₅₀ of 273 μM in rat liver mitochondria.

Methyl benzyl sulfoxide is an uncompetitive inhibitor of horse liver alcohol dehydrogenase with a K_i of 5.0 mM. Methyl benzyl sulfoxide inhibits ethanol metabolism in rats.

Sotagliflozin (Standard) is the analytical standard of Sotagliflozin. This product is intended for research and analytical applications. Sotagliflozin (LX-4211) is a potent dual SGLT2/1 inhibitor. Antidiabetic agents.

8-Hydroxyoctadecanoic acid is an ester product.