Neurological Disease

Autocamtide-3, a 13-amino-acid peptide containing Thr287, is a selective CaMKII (Ca²⁺/calmodulin-dependent kinase II) (CaMK) substrate.

CB2 receptor agonist 4 (Compound 8) is a highly selective cannabinoid receptor type 2 (CB2 Receptor) agonist with an EC₅₀ of 13.99 nM. CB2 receptor agonist 4 shows no significant activity against cannabinoid receptor type 1. CB2 receptor agonist 4 can be used for the research of pain and immune-related diseases.

(R)-Nantenine ((R)-(-)-nantenine) is the levorotatory isomer of Nantenine (HY-N9141). (R)-Nantenine has high affinity and selectivity for the α1A adrenergic receptor. (R)-Nantenine can block the behavioral suppression induced by MDMA. (R)-Nantenine is mainly used for the research related to diseases caused by MDMA abuse.

YIAD-0205 is an orally available Aβ(1?42) aggregation inhibitor. YIAD-0205 demonstrated in vivo efficacy in an AD transgenic mouse model with five familial AD mutations (5XFAD).

Serotonin hydrogen maleate is a monoamine neurotransmitter in the CNS and an endogenous 5-HT receptor agonist. Serotonin hydrogen maleate is also a catechol O-methyltransferase (COMT) inhibitor with a K_i of 44 μM .

MOR antagonist 2 hydrochloride is a blood-brain barrier-permeable μ-opioid receptor (MOR) antagonist, with an IC₅₀ of 28.37 nM, an EC₅₀ of 4.25 nM, and a K_i of 0.18 nM against MOR. MOR antagonist 2 hydrochloride stabilizes the inactive conformation of MOR to reduce receptor activation levels. MOR antagonist 2 hydrochloride antagonizes analgesic effects in the mouse warm-water tail-flick test. MOR antagonist 2 hydrochloride induces fewer opioid withdrawal symptoms (wet dog shakes, paw tremors) in mice with opioid withdrawal symptoms. MOR antagonist 2 hydrochloride can be used for the research of opioid use disorder.

BNP(1-32), porcine (pBNP-32) is a cardiac hormone. BNP(1-32), porcine is an atrial natriuretic peptide, which exhibits natriuretic, diuretic and vasorelaxant effects. BNP(1-32), porcine affects passive avoidance learning in rats with dopaminergic, cholinergic, α-and β-adrenergic mediation.

5-HT_1AR agonist 2 (Compound 4f) is a 5-HT_1A receptor agonist (K_i: 10.0 nM). 5-HT_1AR agonist 2 also binds to the SERT, D₂ receptor and 5-HT₆ receptor (K_i: SERT, 2.8 nM; D₂, 23 nM; 5-HT₆, 192 nM). 5-HT_1AR agonist 2 is stabilized in microsomes and induces hypothermia in mice.

W-2429 (NSC294836) is considerably more effective than acetylsalicylic acid in inhibiting carrageenan-induced edema and in reducing brewer's yeast-induced fever in rats.

Ganoleucoin R is a triterpenoid compound that can be isolated from Ganoderma leucocontextum. Ganoleucoin R exerts a protective effect against H₂O₂-induced oxidative damage and can promote neurite outgrowth in PC12 cells. Ganoleucoin R possesses neuroprotective and neurogenic activities, and can be used in the research of neurodegenerative diseases.

Ethoheptazine is an oraly active analgesic agent. Ethoheptazine can induce toxic effects in mouse and rat models.

4-AcO-DALT hydrochloride is a tryptamine compound with psychoactive effects. 4-AcO-DALT hydrochloride inhibits 5-HT receptors, alpha receptors, dopamine receptors, histamine receptor 1 (H1), muscarinic M2 receptor and Sigma 2 receptor. 4-AcO-DALT hydrochloride shows K_i values of 582 nM, 2689 nM, 2099 nM, 2116 nM, 958 nM, 137 nM, 824 nM, 479 nM, 406 nM, 874 nM, 4190 nM, 482 nM, 214 nM, 803 nM, 4522 nM, 1907 nM for 5-HT1B, 5-HT1D, 5-HT1E, 5-HT2A, 5-HT2B, 5-HT2C, 5-HT6, 5-HT7A, H1, Sigma 2, α2A, α2B, α2C, D2, D3 receptors.

Cyclophostin is an acetylcholinesterase (AChE) inhibitor with IC₅₀ values of 45, 0.76 and 1.3 nM for humans and two different insects, respectively.

L-Tyrosine-d₁ is the deuterium labeled L-Tyrosine (HY-N0473). L-Tyrosine is a non-essential amino acid which can inhibit citrate synthase activity in the posterior cortex.

HCN2 modulator-5 (S-configuration 39) is a HCN2 ion channel inhibitor. HCN2 modulator-5 inhibits HCN2 ion channel activity. HCN2 modulator-5 can be used for the research of pain, inflammatory pain, neuropathic pain, tinnitus, central nervous system disorders, psychiatric disorders, mood disorders.

S-Adenosyl-L-methionine (S-Adenosyl methionine) 1,4-butanedisulfonate is an orally active methyl group donor. S-Adenosyl-L-methionine 1,4-butanedisulfonate is a dietary supplement with potent antidepressant effects. S-Adenosyl-L-methionine 1,4-butanedisulfonate also has anti‑proliferative, pro‑apoptotic and anti‑metastatic roles in cancers. S-Adenosyl-L-methionine 1,4-butanedisulfonate has the potential for, cancer, liver disease and osteoarthritis research.

GsAF-II is a peptide toxin that blocks hERG1 subtype potassium channels in a voltage-dependent manner. GsAF-II blocks Nav1.x subtype sodium channels.

Oseltamivir acid methyl ester is a precursor form of the neuraminidase inhibitor and antiviral oseltamivir acid. Oseltamivir acid methyl ester is converted to oseltamivir acid by carboxylesterase 1 (CES1).

Levoxadrol is an active enantiomer of dexoxadrol.

Tubercidin 5'-triphosphate (7-Deazaadenosine 5'-triphosphate) (Compound II) is an ATP (HY-B2176) analogue. Tubercidin 5'-triphosphate is hydrolyzable by Myosin B. Tubercidin 5'-triphosphate induces weak contraction of rabbit psoas myofibrils.