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Serotonin maleate

(Synonyms: 5-Hydroxytryptamine maleate; 5-HT maleate)
35 Cited Publications
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Based on 35 publication(s) in Google Scholar

Serotonin hydrogen maleate is a monoamine neurotransmitter in the CNS and an endogenous 5-HT receptor agonist. Serotonin hydrogen maleate is also a catechol O-methyltransferase (COMT) inhibitor with a Ki of 44 μM .

For research use only. We do not sell to patients.

  • CAS No.: 18525-25-2
  • Formula: C14H16N2O5
  • Molecular Weight:292.29
  • Storage:

    Please store the product under the recommended conditions in the Certificate of Analysis.

  • Serotonin maleate Chemical Structure
    Serotonin maleate Chemical Structure
  • Experimental Validation Results for Serotonin maleate
  • Experimental Validation Results for Serotonin maleate
  • Experimental Validation Results for Serotonin maleate
  • Experimental Validation Results for Serotonin maleate
  • Experimental Validation Results for Serotonin maleate
CAS No.: 18525-25-2
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Cell Proliferation/Viability AssayELISACell Migration/Invasion AssayRT-PCRWB
  • Cell Migration/Invasion Assay
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  • RT-PCR
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All 5-HT Receptor Isoforms

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  • Serotonin maleate Chemical Structure
    Serotonin maleate Chemical Structure
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    Serotonin maleate purchased from MedChemExpress. Usage Cited in: iScience. 2025 Nov 19;28(12):114120. [Abstract]

    Customer Validation
     Scratch tests were used to observe the migration ability of MLE-12 cells treated with 5-HT (Serotonin, 10 μM) for 24 h.

  • 1/16

    Serotonin maleate purchased from MedChemExpress. Usage Cited in: iScience. 2025 Jun 18;28(7):112931. [Abstract]

    Customer Validation
     SH-SY5Y cells were treated with 10 μM Serotonin (5-HT), then the intracellular 5-HT was detected through ELISA assay for 0, 60, 120 min.

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    Serotonin maleate purchased from MedChemExpress. Usage Cited in: Curr Res Food Sci. 2024 Apr 26:8:100754. [Abstract]

    Customer Validation
     Dose-response and time course of cell viability after in vitro administration of 5-HT(Serotonin);

  • 1/16

    Serotonin maleate purchased from MedChemExpress. Usage Cited in: J Immunother Cancer. 2021 Jul;9(7):e002383. [Abstract]

    Customer Validation
     Relative IDO1 transcription levels detected by quantitative reverse transcription PCR (qRT-PCR) analysis in BT549 cells treated with dimethyl sulfoxide (DMSO), tetrahydrobiopterin (BH4, 10 µM), 5-HTP (500 µM), serotonin (10 µM), NAS (100 µM), and melatonin (1 µM) for 24 hours.

  • 1/16

    Serotonin maleate purchased from MedChemExpress. Usage Cited in: J Immunother Cancer. 2021 Jul;9(7):e002383. [Abstract]

    Customer Validation
     Relative IDO1 levels detected by western blot in BT549 cells treated with dimethyl sulfoxide (DMSO), tetrahydrobiopterin (BH4, 10 µM), 5-HTP (500 µM), serotonin (10 µM), NAS (100 µM), and melatonin (1 µM) for 24 hours.

  • Serotonin maleate