2. GPCR/G Protein Neuronal Signaling Metabolic Enzyme/Protease
  3. 5-HT Receptor COMT
  4. Serotonin maleate

Serotonin maleate  (Synonyms: 5-Hydroxytryptamine maleate; 5-HT maleate)

Cat. No.: HY-169611
Handling Instructions Technical Support

Serotonin hydrogen maleate is a monoamine neurotransmitter in the CNS and an endogenous 5-HT receptor agonist. Serotonin hydrogen maleate is also a catechol O-methyltransferase (COMT) inhibitor with a Ki of 44 μM .

For research use only. We do not sell to patients.

CAS No. : 18525-25-2

Size Stock
50 mg   Get quote  
100 mg   Get quote  
250 mg   Get quote  

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Other In-stock Forms of Serotonin maleate:

Other Forms of Serotonin maleate:

Serotonin maleate Related Antibodies

Top Publications Citing Use of Products
Cell Proliferation/Viability Assay
ELISA
Cell Migration/Invasion Assay
RT-PCR
WB

    Serotonin maleate purchased from MedChemExpress. Usage Cited in: iScience. 2025 Nov 19;28(12):114120.  [Abstract]

    Scratch tests were used to observe the migration ability of MLE-12 cells treated with 5-HT (Serotonin, 10 μM) for 24 h.

    Serotonin maleate purchased from MedChemExpress. Usage Cited in: iScience. 2025 Jun 18;28(7):112931.  [Abstract]

    SH-SY5Y cells were treated with 10 μM Serotonin (5-HT), then the intracellular 5-HT was detected through ELISA assay for 0, 60, 120 min.

    Serotonin maleate purchased from MedChemExpress. Usage Cited in: Curr Res Food Sci. 2024 Apr 26:8:100754.  [Abstract]

    Dose-response and time course of cell viability after in vitro administration of 5-HT(Serotonin);

    Serotonin maleate purchased from MedChemExpress. Usage Cited in: J Immunother Cancer. 2021 Jul;9(7):e002383.  [Abstract]

    Relative IDO1 transcription levels detected by quantitative reverse transcription PCR (qRT-PCR) analysis in BT549 cells treated with dimethyl sulfoxide (DMSO), tetrahydrobiopterin (BH4, 10 µM), 5-HTP (500 µM), serotonin (10 µM), NAS (100 µM), and melatonin (1 µM) for 24 hours.

    Serotonin maleate purchased from MedChemExpress. Usage Cited in: J Immunother Cancer. 2021 Jul;9(7):e002383.  [Abstract]

    Relative IDO1 levels detected by western blot in BT549 cells treated with dimethyl sulfoxide (DMSO), tetrahydrobiopterin (BH4, 10 µM), 5-HTP (500 µM), serotonin (10 µM), NAS (100 µM), and melatonin (1 µM) for 24 hours.

    View All 5-HT Receptor Isoform Specific Products:

    View All Isoforms
    5-HT Receptor 5-HT1 Receptor 5-HT2 Receptor 5-HT3 Receptor 5-HT4 Receptor 5-HT5 Receptor 5-HT6 Receptor 5-HT7 Receptor

    • Biological Activity

    • Purity & Documentation

    • References

    • Customer Review

    Description

    Serotonin hydrogen maleate is a monoamine neurotransmitter in the CNS and an endogenous 5-HT receptor agonist. Serotonin hydrogen maleate is also a catechol O-methyltransferase (COMT) inhibitor with a Ki of 44 μM [1] [2].

    Molecular Weight

    292.29

    Formula

    C14H16N2O5
    CAS No.
    SMILES

    NCCC(C1=C2)=CNC1=CC=C2O.OC(/C=C\C(O)=O)=O
    Shipping

    Room temperature in continental US; may vary elsewhere.
    Storage

    Please store the product under the recommended conditions in the Certificate of Analysis.
    Purity & Documentation
    References
    • No file chosen (Maximum size is: 1024 Kb)
    • If you have published this work, please enter the PubMed ID.
    • Your name will appear on the site.

    Serotonin maleate Related Classifications

    • Molarity Calculator

    • Dilution Calculator

    The molarity calculator equation

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

    Mass   Concentration   Volume   Molecular Weight *
    = × ×

    The dilution calculator equation

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
    × = ×
    C1   V1   C2   V2
    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    Serotonin18525-25-25-Hydroxytryptamine5-HT5-HT ReceptorCOMTSerotonin Receptor5-hydroxytryptamine ReceptorCatechol-O-methyltransferaseInhibitorinhibitorinhibit

    Your Recently Viewed Products:

    Inquiry Online

    Your information is safe with us. * Required Fields.

    Product Name

    		  

    Requested Quantity *

    Applicant Name *

    		 

    Salutation

    Email Address *

    		 

    Phone Number *

    Department

    		 

    Organization Name *

    City

    State

    Country or Region *

    		      

    Remarks

    Bulk Inquiry

    Inquiry Information

    Product Name:
    Serotonin maleate
    Cat. No.:
    HY-169611
    Quantity:
    MCE Japan Authorized Agent:

    Customer Review

    Thank You for Your Feedback!

    Request for HNMR Report

    Please fill out this form to request the QC report. We will send it to your Email address shortly.

    Your information is safe with us. * Required Fields.

    Product Name

    		  

    Lot #

    Applicant Name *

    		 

    Email Address *

    Phone Number

    		 

    Department *

    Organization Name *

    		 

    Country or Region *

    Remarks

    SAFETY DATA SHEET (SDS)

    Request for HNMR Report

    We have received your request and will respond to you as soon as possible.