Others

RWJ-68022 (Example 9) is a cyclopentene derivative and a motilin receptor antagonist. RWJ-68022 can compete with motilin and erythromycin for the motilin receptor site. RWJ-68022 can be used in the research of gastrointestinal-related diseases.

Glycerophosphoinositol 4,5-diphosphate (GroPI(4,5)P2) trisodium is a slowly metabolized analog of InsP₃. Glycerophosphoinositol 4,5-diphosphate trisodium has an EC₅₀ of 1.228 μM for inducing calcium release, with a degradation time constant of 13 seconds. Glycerophosphoinositol 4,5-diphosphate trisodium can be used to study the effect of InsP₃ degradation on calcium signal recovery.

(R)-(-)-Linoleyl-2'-hydroxy-1'-propylamide is a LOEA homolog, which can be characterized by the addition of an (R)-β-methyl group at the terminal ethanolamine carbon.

(R)-(-)-Docosahexaenyl-2'-hydroxy-1'-propylamide is a DHEA homolog. (R)-(-)-Docosahexaenyl-2'-hydroxy-1'-propylamide is characterized by the addition of an (R)-β-methyl group at the terminal ethanolamine carbon.

BCP-NC2-C12 is an ionizable cationic lipid. BCP-NC2-C12 can be used to generate lipid nanoparticles (LNPs) for in vivo delivery of mRNA. BCP-NC2-C12 LNPs mediated an approximately 90% reduction in PCSK9 serum protein levels via CRISPR/Cas9 gene knockout.

5-Aza-N6-benzoyl-5'-O-DMT-2'-deoxycytidine 3'-CE phosphoramidite is a phosphoramidite that can be used in the synthesis of oligonucleotides.

6-O-Oleoyltrehalose is a derivative of trehalose. 6-O-Oleoyltrehalose has biodegradable and low surface tension reduction ability. 6-O-Oleoyltrehalose preserves Lactate dehydrogenase (LDH) activity during freeze/thaw cycles. 6-O-Oleoyltrehalose can be used for stabilizer research.

31hP is an asymmetric A³ lipid. 31hP can facilitate in vivo luciferase expression. 31hP can be rapidly degraded in the presence of esterase owing to two biocleavable ester bonds. 31hP can be used in the synthesis of lipid nanoparticles (LNPs).

THP1 Lipid is an ionizable lipidoid. THP1 Lipid can be used to synthesize lipid nanoparticles (LNPs) for delivering mRNA to muscles with minimal toxicity and editing genes in specific liver tissues in tdTomato transgenic mice model. THP1 Lipid can be used for vaccine delivery and CRISPR/Cas9-mediated gene editing research.

ATII (Traseolide), a Polycyclic musk fragrance, is a hydrophobic hapten. ATII has no genotoxicity in the human lymphocytes and the human hepatoma cell line Hep G2. ATII can be bound by antibody M02/05/01 (H93 Val) with superior binding capacity. ATII can be conjugated to carrier proteins for antigen design.

DCPD is an amine substance with both embryotoxicity and teratogenicity, and its total effect ED₅₀ is 0.6 μmol per egg. DCPD induces early and late embryonic death, and causes multiple embryonic malformations including microcephaly, hypoplastic optic cup, eyelid and corneal defects. DCPD can serve as a calcium phosphate additive for biomimetic α-tricalcium phosphate bone cement, which inhibits the transformation of α-tricalcium phosphate into calcium-deficient hydroxyapatite, blocks the release of Gelatins (HY-Y1365), and effectively prolongs the setting time of bone cement. DCPD is applicable to studies related to embryonic malformations.\n

trans-4-Hydroxyprolinol-C10-tri-GalNAc (Formula XXIV) is a Tri-GaINAc derivative that can be used for nucleic acid drug coupling.

(±)-Biotin sulfoxide is a racemic mixture of the Biotin sulfoxide (HY-W129869).

Strychnospermine is an alkaloid that has been found in S. psilosperma.

Porantherine is an alkaloid that has been found in Poranthera corymbosa.

N-Methylcanadium iodide is an alkaloid compound.

CAI/II-IN-10 (Compound 5d) is a human carbonic anhydrase I and II (hCA I and hCA II) inhibitor with IC< The sub>50 values are 4.32 and 3.89 nM respectively.

FITC-lysine-dextran, 500kDa is a dextran with lysine coupling with a fluorescent group FITC (HY-66019). Lysine-dextran exhibits higher Glu-plasminogen binding ability than dextran alone.

Lysine-dextran, 4kDa is a dextran with lysine coupling. Lysine-dextran exhibits higher Glu-plasminogen binding ability than dextran alone.

Lysine-dextran, 10kDa is a dextran with lysine coupling. Lysine-dextran exhibits higher Glu-plasminogen binding ability than dextran alone.