1. GPCR/G Protein
    Neuronal Signaling
  2. Neurokinin Receptor
  3. Scyliorhinin II

Scyliorhinin II 

Cat. No.: HY-P1588
Handling Instructions

Scyliorhinin II is a selective neurokinin-3 receptor agonist, with a Ki of 2.5 nM for neurokinin-3 receptor in rat cerebral cortex.

For research use only. We do not sell to patients.

Custom Peptide Synthesis

Scyliorhinin II Chemical Structure

Scyliorhinin II Chemical Structure

CAS No. : 112748-19-3

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Description

Scyliorhinin II is a selective neurokinin-3 receptor agonist, with a Ki of 2.5 nM for neurokinin-3 receptor in rat cerebral cortex.

IC50 & Target

Ki: 2.5 nM (Neurokinin-3 receptor)[1]

In Vitro

Scyliorhinin II is a neurokinin-3 selective tachykinin receptor, with a Ki of 2.5 nM for neurokinin-3 (NK-3) receptor in rat cerebral cortex. Scyliorhinin II has little effect on NK-1 and NK-2 receptors, with Ki (NK-1 receptor)/Ki (NK-3 receptor) and Ki (NK-2 receptor)/Ki (NK-3 receptor) of 176 and 200[1].

In Vivo

Scyliorhinin II produces potent, dose-related reciprocal hindlimb scratching about equipotently with an ED50 of 0.08 nmol via intracerebroventricularly (i.c.v.) administration in mice[2].

Molecular Weight

1851.09

Formula

C₇₇H₁₁₉N₂₁O₂₆S₃

CAS No.

112748-19-3

Sequence

Ser-Pro-Ser-Asn-Ser-Lys-Cys-Pro-Asp-Gly-Pro-Asp-Cys-Phe-Val-Gly-Leu-Met-NH2

Sequence Shortening

SPSNSKCPDGPDCFVGLM-NH2

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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Keywords:

Scyliorhinin IINeurokinin ReceptorNK receptorInhibitorinhibitorinhibit

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