Scyliorhinin II
Scyliorhinin II is a selective neurokinin-3 receptor agonist, with a Ki of 2.5 nM for neurokinin-3 receptor in rat cerebral cortex.
For research use only. We do not sell to patients.
- CAS No.: 112748-19-3
- Formula: C77H119N21O26S3
- Molecular Weight:1851.09
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
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HY-P1492
Substance P (7-11)Active Compound -
HY-P1494
Substance P (1-9)Neurokinin Receptor -
HY-P0197
Neurokinin APeptide Neurotransmitter -
HY-19632
FezolinetantNK3R Antagonist -
HY-P0242
Neurokinin BNeurokinin 3 Receptor Activator -
HY-14552
TalnetantNK3 Receptor Antagonist -
![[Sar9,Met(O2)11]-Substance P](https://file.medchemexpress.com/product_pic/hy-p1012.gif)
HY-P1012
[Sar9,Met(O2)11]-Substance PTachykinin NK1 Receptor Agonist -
HY-14432
PavinetantNeurokinin Receptor Antagonist -
HY-16732
TradipitantNK-1 Receptor Antagonist -
![[Sar9] Substance P](https://file.medchemexpress.com/product_pic/hy-p1738.gif)
HY-P1738
[Sar9] Substance PNeurokinin Receptor Agonist -
HY-P0201
Substance PNeurotransmitter -
HY-10053
MaropitantNK1 Receptor Antagonist
Biological Activity
Description
IC50 & Target
Ki: 2.5 nM (Neurokinin-3 receptor)[1]
In Vitro
Scyliorhinin II is a neurokinin-3 selective tachykinin receptor, with a Ki of 2.5 nM for neurokinin-3 (NK-3) receptor in rat cerebral cortex. Scyliorhinin II has little effect on NK-1 and NK-2 receptors, with Ki (NK-1 receptor)/Ki (NK-3 receptor) and Ki (NK-2 receptor)/Ki (NK-3 receptor) of 176 and 200[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. .
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 112748-19-3
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Molecular Weight 1851.09
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Formula C77H119N21O26S3
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Sequence
Ser-Pro-Ser-Asn-Ser-Lys-Cys-Pro-Asp-Gly-Pro-Asp-Cys-Phe-Val-Gly-Leu-Met-NH2
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Sequence Shortening
SPSNSKCPDGPDCFVGLM-NH2
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Buck SH, et al. The dogfish peptides scyliorhinin I and scyliorhinin II bind with differential selectivity to mammalian tachykinin receptors. Eur J Pharmacol. 1987 Nov 24;144(1):109-11. [Content Brief]
[2]. Raffa RB, et al. Scyliorhinin-I and -II induce reciprocal hindlimb scratching in mice: differentiation of spinal and supraspinal neurokinin receptors in vivo. Neurosci Lett. 1993 Aug 6;158(1):87-91. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Scyliorhinin II Related Classifications
HY-P1588 Related Classifications
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