1. Anti-infection
  2. HCV
  3. TMC647055 Choline salt

TMC647055 Choline salt 

Cat. No.: HY-15591A Purity: 98.06%
COA Handling Instructions

TMC647055 (Choline salt) is a potent nonnucleoside NS5B polymerase inhibitor of HCV replication. TMC647055 Choline salt has potent HCV combine activity with an IC50 value of 82 nM. TMC647055 Choline salt can be used for the research of Hepatitis C virus (HCV).

For research use only. We do not sell to patients.

TMC647055 Choline salt Chemical Structure

TMC647055 Choline salt Chemical Structure

Size Price Stock Quantity
Solution
10 mM * 1 mL in DMSO USD 577 In-stock
Estimated Time of Arrival: December 31
Solid + Solvent
10 mM * 1 mL
ready for reconstitution
USD 577 In-stock
Estimated Time of Arrival: December 31
Solid
5 mg USD 360 In-stock
Estimated Time of Arrival: December 31
10 mg USD 540 In-stock
Estimated Time of Arrival: December 31
50 mg USD 1560 In-stock
Estimated Time of Arrival: December 31
100 mg USD 2520 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

* Please select Quantity before adding items.

Customer Review

Based on 1 publication(s) in Google Scholar

Top Publications Citing Use of Products

1 Publications Citing Use of MCE TMC647055 Choline salt

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

TMC647055 (Choline salt) is a potent nonnucleoside NS5B polymerase inhibitor of HCV replication. TMC647055 Choline salt has potent HCV combine activity with an IC50 value of 82 nM. TMC647055 Choline salt can be used for the research of Hepatitis C virus (HCV)[1][2].

IC50 & Target

EC90: 0.3 μM (Huh7-Luc cell)[1].
EC50: 82 nM (HCV)[2]

In Vitro

TMC647055 (Choline salt) has antiviral activity with an EC90 value of 0.3 μM in Huh7-Luc cells[1].
TMC647055 Choline salt has potent combine activity with an EC50 value of 82 nM in cellular HCV assays[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

TMC647055 Choline salt (compound 18a) (2 mg/kg, iv.; 10mg/kg, po.) shows an acceptable PK profile, characterized by high oral bioavailability and high systemic exposure after single oral dosing of 10 mg/kg, combined with a moderate plasma clearanceand low volume of distribution[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Rats[2]
Dosage: 2 mg/kg; 10mg/kg
Administration: 2 mg/kg, iv.; 10mg/kg, po.; singel
Result:
No. Cl (L/h/kg) Cmax(ng/mL) [Liver] (ng/mL) L/P F (%)
TMC647055 (compound 18a) 3.2 440 7800 46 >66
Clinical Trial
Molecular Weight

727.91

Formula

C37H53N5O8S

SMILES

OCC[N+](C)(C)C.COC1=CC2=C(C=C1)C3=C(C4CCCCC4)C5=CC=C(C6=O)C=C5N3CC(C(N(C)CCOCCN(S(N6)(=O)=O)C)=O)=C2.[OH-]

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : ≥ 43 mg/mL (59.07 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.3738 mL 6.8690 mL 13.7380 mL
5 mM 0.2748 mL 1.3738 mL 2.7476 mL
10 mM 0.1374 mL 0.6869 mL 1.3738 mL
*Please refer to the solubility information to select the appropriate solvent.
Purity & Documentation
References
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Product Name:
TMC647055 Choline salt
Cat. No.:
HY-15591A
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