TMC647055 Choline salt
Based on 4 publication(s) in Google Scholar
TMC647055 (Choline salt) is a potent nonnucleoside NS5B polymerase inhibitor of HCV replication. TMC647055 Choline salt has potent HCV combine activity with an IC50 value of 82 nM. TMC647055 Choline salt can be used for the research of Hepatitis C virus (HCV).
Para uso exclusivo en investigación. No vendemos a pacientes.
- Pureza : 99.43%
- Fòrmula: C37H53N5O8S
- Peso molecular:727.91
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Almacenamiento:
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
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Actividad biológica
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Chemical Information
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Solvente y solubilidad
- Pureza y Documentación
- Referencias
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) TMC647055 Choline salt
More
Actividad biológica
Descripciòn
IC50 & Target
In Vitro
TMC647055 (Choline salt) has antiviral activity with an EC90 value of 0.3 μM in Huh7-Luc cells[1].
TMC647055 Choline salt has potent combine activity with an EC50 value of 82 nM in cellular HCV assays[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Rats[2]
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Dosage:2 mg/kg; 10mg/kg
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Administration:2 mg/kg, iv.; 10mg/kg, po.; singel
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Result:
No. Cl (L/h/kg) Cmax(ng/mL) [Liver] (ng/mL) L/P F (%) TMC647055 (compound 18a) 3.2 440 7800 46 ＞66
Ensayo clínico
| NCT Number | Sponsor | Condition | Start Date |
Phase
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|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Chemical Information
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Appearance Solid
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Peso molecular 727.91
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Fòrmula C37H53N5O8S
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Color White to off-white
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SMILES
OCC[N+](C)(C)C.COC1=CC2=C(C=C1)C3=C(C4CCCCC4)C5=CC=C(C6=O)C=C5N3CC(C(N(C)CCOCCN(S(N6)(=O)=O)C)=O)=C2.[OH-]
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Publications (4)
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Journal Impact Factor
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Most Recent
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Plant Cell
SlSEC1- and SlSPY-mediated O-glycosylation stabilizes the transcription factor SlNOR to promote tomato fruit ripening. [Abstract]2026 May 14:koag144. PMID: 42135064 -
Antiviral Res
2026 Jun 22:252:106470. PMID: 42331291 -
Antiviral Res
Antiviral candidates against the hepatitis E virus (HEV) and their combinations inhibit HEV growth in in vitro. [Abstract]2019 Oct:170:104570. PMID: 31362004 -
Arch Microbiol
Antibacterial and antibiofilm efficacy of TMC647055 against methicillin-resistant Staphylococcus aureus. [Abstract]2025 Nov 1;207(12):335. PMID: 41175257
Solvente y solubilidad
In Vitro:
DMSO : 62.5 mg/mL (85.86 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
In Vivo:
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.08 mg/mL (2.86 mM); Clear solution
This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL. * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Pureza y Documentación
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Ficha de datos (283 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Instrucciones de manejo (2659 KB)
Referencias
[1]. Devogelaere B, et al. TMC647055, a potent nonnucleoside hepatitis C virus NS5B polymerase inhibitor with cross-genotypic coverage. Antimicrob Agents Chemother. 2012 Sep;56(9):4676-4684. [Content Brief]
[2]. Sandrine Vendeville, et al. Finger loop inhibitors of the HCV NS5b polymerase. Part II. Optimization of tetracyclic indole-based macrocycle leading to the discovery of TMC647055. Bioorg Med Chem Lett. 2012 Jul 1;22(13):4437-43. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.3738 mL | 6.8690 mL | 13.7380 mL | 34.3449 mL |
| 5 mM | 0.2748 mL | 1.3738 mL | 2.7476 mL | 6.8690 mL | |
| 10 mM | 0.1374 mL | 0.6869 mL | 1.3738 mL | 3.4345 mL | |
| 15 mM | 0.0916 mL | 0.4579 mL | 0.9159 mL | 2.2897 mL | |
| 20 mM | 0.0687 mL | 0.3434 mL | 0.6869 mL | 1.7172 mL | |
| 25 mM | 0.0550 mL | 0.2748 mL | 0.5495 mL | 1.3738 mL | |
| 30 mM | 0.0458 mL | 0.2290 mL | 0.4579 mL | 1.1448 mL | |
| 40 mM | 0.0343 mL | 0.1717 mL | 0.3434 mL | 0.8586 mL | |
| 50 mM | 0.0275 mL | 0.1374 mL | 0.2748 mL | 0.6869 mL | |
| 60 mM | 0.0229 mL | 0.1145 mL | 0.2290 mL | 0.5724 mL | |
| 80 mM | 0.0172 mL | 0.0859 mL | 0.1717 mL | 0.4293 mL |
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