Lipoxygenase
LOX
Lipoxygenases (LOXs) are a family of enzymes that are responsible for the metabolism of arachidonic and docosahexaenoic acid and for the formation of several eicosanoids and docosanoids, including leukotrienes, lipoxins and neuroprotectins. Depending on cells' redox state and other milieu conditions, these enzymes are engaged in oxidative stress and cell death mechanisms or in cell protection. Lipoxygenases are lipid peroxidizing enzymes, implicated in the pathogenesis of inflammatory and hyperproliferative diseases, which represent potential targets for pharmacological intervention.
Lipoxygenases are classified on the basis of site of arachidonate oxygenation into 5-, 8-, 9-, 11-, 12- and 15-LOX. The prominent animal LOXs are 5-LOX, 8-LOX, 12-LOX and 15-LOX, while the plant LOXs are mostly 5-LOX and 15-LOX. Among these, 5-LOX is the most predominant isoform associated with the formation of 5-hydroperoxyeicosatetraenoic acid (5-HpETE) and other bioactive lipid mediators.
Lipoxygenase Isoform Specific Products
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Lipoxygenase Inhibitors
(276)
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Lipoxygenase Antagonists
(2)
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Lipoxygenase Activators
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Lipoxygenase Modulators
(3)
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Lipoxygenase Control
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Lipoxygenase Substrates
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Lipoxygenase Ligand
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Lipoxygenase Related Products (309)
Related Products (309)
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Antibodies (5)
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Lipoxygenase Isoform Comparison
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COX-2/15-LOX-IN-2
0 ImagesCat. No.: HY-155159CAS No.: 3052736-49-6
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ALOX5 stabilizer-1 TFA
0 ImagesCat. No.: HY-175634AALOX5 stabilizer-1 TFA is an arachidonate 5-lipoxygenase (ALOX5) stabilizer with a Kd of 7.26 μM. ALOX5 stabilizer-1 TFA inhibits β-catenin protein levels and then suppresses STAT3 signal pathway. ALOX5 stabilizer-1 TFA induces lung cancer cells apoptosis, inhibited cell migration and proliferation. ALOX5 stabilizer-1 TFA can used for the study of non-small cell lung cancer (NSCLC).
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Picrinine (Standard)
0 ImagesPicrinine (Standard) is the analytical standard of Picrinine. This product is intended for research and analytical applications. Picrinine, an akuammiline alkaloid, is isolated from the leaves of Alstonia scholaris. Picrinine exhibits anti-inflammatory activity through inhibition of the 5-lipoxygenase enzyme.
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CGS 24891
0 ImagesCat. No.: HY-182696CAS No.: 134823-10-2CGS 24891 is an orally active 5-lipoxygenase (5-LO) inhibitor, with an IC50 value of 0.051 μM in guinea pigs and 0.11 μM in dogs. CGS 24891 inhibits the production of 5-hydroxyeicosatetraenoic acid (5-HETE) and leukotriene B4 (LTB4) from arachidonic acid. CGS 24891 weakly inhibits 12-lipoxygenase (12-LO) with an IC50 of 0.41 μM. CGS 24891 is applicable to research on inflammation and allergic reactions.
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Tagorizine
0 ImagesCat. No.: HY-119462CAS No.: 118420-47-6Tagorizine is a 5-LOX inhibitor. Tagorizine can be used to study cerebral (or peripheral) blood vessel dilation.
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CV-6504
0 ImagesCat. No.: HY-19064CAS No.: 117574-40-0CV-6504 is a dual inhibitor of TXA2 synthase and 5-lipoxygenase. CV-6504 can scavenge ROS and exhibit antitumor activity. CV-6504 can be used for the researches of cancer, inflammation and cardiovascular disease.
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5,6-Dehydroarachidonic acid
0 ImagesCat. No.: HY-131895CAS No.: 58688-54-35,6-Dehydroarachidonic acid is a 5-lipoxygenase (Lipoxygenase) inhibitor that inhibits the biosynthesis of leukotrienes. However, 5,6-Dehydroarachidonic acid had no effect on vascular cell proliferation.
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WY-50295
0 ImagesCat. No.: HY-19114CAS No.: 123016-21-7WY-50295 is an orally active and selective 5-lipoxygenase inhibitor. WY-5029 inhibits LTB4 formation in rat whole blood leukocytes (IC50: 40 μM and oral ED50: 18 mg/kg). WY-50295 can be used in the study of asthma and other leukotriene-dependent diseases.
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Caffeoylcalleryanin
0 ImagesCat. No.: HY-N12987CAS No.: 20300-49-6Caffeoylcalleryanin is a potent 15-lipoxygenase inhibitor with an IC50 value of 1.59 µM. Caffeoylcalleryanin shows no cytotoxic.
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AHR-5333 mandelate
0 ImagesCat. No.: HY-116638ACAS No.: 128766-12-1AHR-5333 mandelate is a selective human blood neutrophil 5-lipoxygenase inhibitor. AHR-5333 mandelate exhibits potent, long-acting activity in rat and guinea pig in vivo models of immediate hypersensitivity.
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E 3040
0 ImagesCat. No.: HY-105193CAS No.: 145096-30-6E 3040 is an orally active dual inhibitor of 5-lipoxygenase and thromboxane synthase. E 3040 exhibits anti-inflammatory effect.
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KC-11404
0 ImagesCat. No.: HY-182557CAS No.: 148490-22-6KC-11404 is an orally active antihistamine and 5-lipoxygenase inhibitor, with an IC50 of 0.9 μM against guinea pig 5-lipoxygenase. KC-11404 inhibits histamine-induced contraction of isolated guinea pig ileum with an IC50 of 0.26 μM. KC-11404 inhibits PAF-induced rabbit platelet aggregation with an IC50 of 2.0 μM. It inhibits the histamine phase of antigen-induced bronchoconstriction and PAF-induced bronchoconstriction in guinea pigs. KC-11404 can be used for the research of asthma.
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P-8977
0 ImagesCat. No.: HY-108109CAS No.: 135810-00-3P-8977 is a potent dual CO/5-LO inhibitor (IC50 = 0.01 µM). P-8977 can also inhibit cyclooxygenase (CO) (IC50 = 0.53 µM) in 3T3 cells. P-8977 can inhibit ear edema. P-8977 can be used for research on inflammatory skin conditions.
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Psoralidin (Standard)
0 ImagesPsoralidin (Standard) is the analytical standard of Psoralidin. This product is intended for research and analytical applications. Psoralidin is a dual inhibitor of COX-2 and 5-LOX, regulates ionizing radiation (IR)-induced pulmonary inflammation.Anti-cancer, anti-bacterial, and anti-inflammatory properties. Psoralidin significantly downregulates NOTCH1 signaling. Psoralidin also greatly induces ROS generation.
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(2E,9Z)-Octadeca-2,9-dienoic acid
0 ImagesCat. No.: HY-145952CAS No.: 182369-03-5(2E,9Z)-Octadeca-2,9-dienoic acid, a polyunsaturated fatty acid, can be used for the research of lipoxygenase-dependent metabolism.
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COX-2/15-LOX-IN-4
0 ImagesCat. No.: HY-155161CAS No.: 3052736-45-2COX-2/15-LOX-IN-4 (compound 5i) is a dual inhibitor of COX-2/15-LOX with IC50s of 0.075 μM and 1.97 μM, respectively. COX-2/15-LOX-IN-4 can inhibit LPS-induced cell production of promoting cytokines (IL-6, ROS) with specific anti-inflammatory activity.
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COX-2/15-LOX-IN-5
0 ImagesCat. No.: HY-163355CAS No.: 443790-30-5COX-2/15-LOX-IN-5 (Compound 4f) is a dual inhibitor of COX-2/15-LOX. COX-2/15-LOX-IN-5 attenuates increased NF-κB activation in RAW 264.7 macrophages mediated by lipopolysaccharide (HY-D1056). COX-2/15-LOX-IN-5 has anti-inflammatory and antioxidant activities.
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SKF-105809
0 ImagesCat. No.: HY-19086CAS No.: 122454-69-7SKF-105809 is a dual-action inhibitor of lipoxygenase and COX. SKF-105809 inhibits edema and inflammatory cell infiltration in mouse models of ear, paw, and peritoneum inflammation. SKF-105809 inhibits the production of relevant acute-phase reactive proteins in a mouse model of arthritis. SKF-105809 exhibits analgesic activity in a mouse abdominal contraction test and inhibits ulceration. SKF-105809 can be used in research on inflammatory and immune system diseases such as peritonitis and arthritis.
