2. Signaling Pathways
  3. Cell Cycle/DNA Damage
  4. Antifolate
  5. Antifolate Substrate

Antifolate Substrate

Antifolate Substrate (1):

Cat. No. Product Name Effect Purity
  • HY-113798
    ICI 198583
    		Substrate
    ICI 198583 is a thymidylate synthase (TS) inhibitor with a Ki value of 10 nM for both mouse and human TS. ICI 198583 serves as a substrate for folylpolyglutamate synthetase (FPGS) with a Km of 40 μM. ICI 198583 exerts persistent, dose-dependent inhibition on thymidylate synthase flux in mice. ICI 198583 is applicable to relevant research on leukemia.