Cathepsin
Cathepsins are protease enzymes, categorized into multiple families. Cathepsins can be serine protease, cysteine protease, or aspartyl protease. There are about 15 classes of cathepsins in humans (Cathepsin A, B, C, D, E, F, G, H, K, L, O, S, V, W, and Z). Cathepsins are active in the low pH milieu of lysosomes and are versatile in their functions. Like other enzymes, they are vital for the normal physiological functions such as digestion, blood coagulation, bone resorption, ion channel activity, innate immunity, complement activation, apoptosis, vesicular trafficking, autophagy, angiogenesis, proliferation, and metastasis, among scores of others.
Numerous pathologies have been attributed to the dysregulated cathepsins, some of which include arthritis, periodontitis, pancreatitis, macular degeneration, muscular dystrophy, atherosclerosis, obesity, stroke, Alzheimer's disease, schizophrenia, tuberculosis, and Ebola.
Cathepsin Isoform Specific Products
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Cathepsin Inhibitors
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Cathepsin Antagonist
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Cathepsin Activators
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Cathepsin Inducers
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Cathepsin Degrader
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Cathepsin Control
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Cathepsin Substrates
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Cathepsin Ligand
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Cathepsin Proteins
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Cathepsin B Proteins
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Cathepsin C Proteins
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Cathepsin D Proteins
(5)
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Cathepsin E Proteins
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Cathepsin K Proteins
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Cathepsin L1 Proteins
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Cathepsin S Proteins
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Cathepsin Related Products (297)
Related Products (297)
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Recombinant Proteins (35)
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Antibodies (6)
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Cathepsin Isoform Comparison
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Gardenin B (Standard)
0 ImagesGardenin B (Standard) is the analytical standard of Gardenin B (HY-N6037). This product is intended for research and analytical applications. Gardenin B is a flavonoid isolated from Gardenia jasminoides. Gardenin B is a methoxyflavone compound and an inhibitor of USP7, ODC (IC50: 6.24 μg/mL), and Cathepsin D (IC50: 5.61 μg/mL). Gardenin B exhibits antioxidant and antitumor activities. Gardenin B shows IC50 values of 8.87 and 10.59 μg/mL for DPPH and NO scavenging, respectively, and also possesses ferric ion reducing ability. Additionally, Gardenin B can inhibit tumor cell proliferation, induce cell cycle arrest and apoptosis. Gardenin B can be used in cancer research.
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Ctsb Mouse Pre-designed siRNA Set A
0 ImagesCat. No.: HY-RS03323Ctsb Mouse Pre-designed siRNA Set A contains three designed siRNAs for Ctsb gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
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Ctse Rat Pre-designed siRNA Set A
0 ImagesCat. No.: HY-RS03333Ctse Rat Pre-designed siRNA Set A contains three designed siRNAs for Ctse gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
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Cathepsin L-IN-6
0 ImagesCat. No.: HY-180799CAS No.: 3077842-39-5Cathepsin L-IN-6 (Compound 6a) is a selective cathepsin L inhibitor with an IC50 of 0.021 μM. Cathepsin L-IN-6 suppresses cathepsin L activity by directly binding to cathepsin L. Cathepsin L-IN-6 inhibits IL-6 and IL-8. Cathepsin L-IN-6 shows a high anti-inflammatory activity. Cathepsin L-IN-6 can be used in the research of acute lung injury.
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CLIK-148
0 ImagesCat. No.: HY-164634CAS No.: 215098-90-1CLIK-148 is a highly selective, irreversible and orally active cysteine protease inhibitor, primarily targeting Cathepsin L. CLIK-148 effectively inhibits the Cathepsin L-dependent degradation of HMG-CoA reductase in the endoplasmic reticulum (ER) membrane. CLIK-148 inhibits the processing of proCCK by Cathepsin L, thereby reducing the production of CCK8 (HY-P0093). CLIK-148 inhibits the degradation of type I collagen by osteoclasts' secreted Cathepsin L, reducing tumor-induced bone metastasis and malignant hypercalcemia. CLIK-148 can be used for the studies of bone metabolism disorders and regulation of neuropeptide processing.
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Z-Arg-Arg-4MβNA triacetate
0 ImagesCat. No.: HY-D1523CAS No.: 100900-19-4Z-Arg-Arg-4MβNA triacetate is a cathepsin B-specific substrate and can produce fluorescent end product 4MβNA (λex = 355 nm, λem = 430 nm).
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Cathepsin L-IN-3
0 ImagesCat. No.: HY-P10118CAS No.: 478164-48-6Cathepsin L-IN-3 (Compound cat L inh. 7) is selective a noncovalent cathepsin L inhibitor with a Ki of 4.3 nM.
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Ferroptosis inducer-16
0 ImagesCat. No.: HY-182052CAS No.: 3063042-21-4Synonyms: anti-NSCLC agent-2Ferroptosis inducer-16 (anti-NSCLC agent-2) is a nitric oxide (NO) donor and a ferroptosis inducer. Ferroptosis inducer-16 inhibits DNA synthesis and colony formation. Ferroptosis inducer-16 disrupts lysosomal integrity by releasing NO, triggers iron overload and oxidative stress, downregulates the SLC7A11-GPX4 axis, depletes GSH, and accumulates lipid peroxides. Ferroptosis inducer-16 inhibits tumor growth in an OVCAR8/ADR xenograft mouse model without obvious toxicity, and can be used in the study of non-small cell lung cancer and drug-resistant ovarian cancer.
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H-Gly-Arg-NH2
0 ImagesCat. No.: HY-P5086CAS No.: 24326-03-2H-Gly-Arg-NH2 is a substrate for the determination of bovine spleen cathepsin C activity.
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ABP 25
0 ImagesCat. No.: HY-139685CAS No.: 2965359-45-7ABP 25 is an activity-based probe for cathepsin K imaging with excellent potency and selectivity.
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SQ 32056
0 ImagesCat. No.: HY-125386CAS No.: 139113-49-8SQ 32056 is a cathepsin E inhibitor. SQ 32056 can block the pressor response to endothelin.
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Leupeptin Ac-LL
0 ImagesCat. No.: HY-18234BCAS No.: 24365-47-7Leupeptin Ac-LL is a broad-spectrum protease inhibitor. Leupeptin Ac-LL inhibits serine, cysteine and threonine proteases, and regulates autophagy. Leupeptin Ac-LL reduces the expression levels of LC3B, iNOS, Cox-2, Beclin-1 and the level of endopeptidases; increases the levels of p62, Arg 1, Msr 1 and Mrc−1; and blocks the upregulation of p-PTEN, p-NF-κB, p-PI3K, p-Akt, p-p38 and ERK1/2. Leupeptin Ac-LL inhibits NO, ROS, proinflammatory cytokines, the IFN-γ/IL-10 ratio, phagolysosome fusion, mammalian lysosomal hydrolase activity and SARS-CoV-2 replication; and reverses impaired autophagic flux. Leupeptin Ac-LL is applicable to research related to chronic inflammatory diseases, edema, skin tumorigenesis, COVID-19 and respiratory infections.
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FGA139
0 ImagesCat. No.: HY-172977FGA139 is a cysteine proteases inhibitor with IC50 values of 4.98/3.14 μM for cathepsin B/L. FGA139 reduces LPS-induced NO production in RAW264.7 cells and tumor necrosis factor (TNFα) levels in microglia, and has anti-oxidative stress and anti-inflammatory activities. FGA139 promotes the secretion of neuroprotective metabolites purine and linoleic acid by LPS-stimulated microglia. FGA139 can be used in neuroinflammatory diseases research.
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(Rac)-Neurodegenerative Disorder-Targeting Compound 1
0 ImagesCat. No.: HY-U00362ACAS No.: 1254699-12-1(Rac)-Neurodegenerative Disorder-Targeting Compound 1 is a calpain inhibitor (extracted from patent WO2010128102A1, compound 63) .
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Z-Arg-Lys-AOMK diTFA
0 ImagesCat. No.: HY-183166AZ-Arg-Lys-AOMK diTFA is a cathepsin B inhibitor that can cross the blood-brain barrier. Z-Arg-Lys-AOMK diTFA reduces cytosolic cathepsin B activity in homogenates of mouse cerebral cortex and hippocampal tissues, and alleviates motor dysfunction associated with CCI-TBI. Z-Arg-Lys-AOMK diTFA can be used in the research of traumatic brain injury.
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Olgotrelvir
0 ImagesCat. No.: HY-156655CAS No.: 2763596-71-8Synonyms: STI-1558Olgotrelvir (STI-1558) is an orally active dual inhibitor of coronavirus main protease (Mpro) and human cell cathepsin (Cathepsin L). Olgotrelvir is readily converted to its active form, AC1115, in full blood and/or plasma. Olgotrelvir can effectively inhibit both SARS-CoV-2 replication and entry into host cells.
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Phe-Arg-Arg-Gly
0 ImagesCat. No.: HY-P4565CAS No.: 642080-61-3Phe-Arg-Arg-Gly is a polypeptide that can be used for agent coupling.
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Papain (USP)
0 ImagesCat. No.: HY-E71363Papain (USP) refers to Papain (HY-P1645) that meets the standards of the US Pharmacopoeia. Papain is a cysteine protease of the peptidase C1 family. Papain enhances red cell agglutination by anti-D and anti-A, and increases red cell sensitivity to K cell-mediated lysis in ADCC assays. Papain can induce pulmonary emphysema. Papain can be used for the researches of Rh haemolytic disease of the newborn and pulmonary emphysema.
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Z-L(D-Val)G-CHN2
0 ImagesCat. No.: HY-108137APurity: 99.35%Z-L(D-Val)G-CHN2 is the isoform of Z-LVG-CHN2 (HY-108137). Z-LVG-CHN2 is a cell-permeable and irreversible inhibitor of cysteine proteinase. Z-LVG-CHN2 is a tripeptide derivative and mimics part of the human cysteine proteinase-binding center. Z-LVG-CHN2 displays an inhibition on HSV whereas no significant effect on poliovirus replication. Z-LVG-CHN2 effectively blocks SARS-COV-2 replication (EC50=190 nM) via inhibition of SARS-COV-2 3CL pro protease.
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K777 tosylate
0 ImagesCat. No.: HY-119293ACAS No.: 502960-91-0K777 tosylate is a potent, orally active and irreversible cysteine protease inhibitor. K777 tosylate is also a potent CYP3A4 inhibitor with an IC50 of 60 nM. K777 tosylate irreversibly inhibits Cruzain, the major cysteine protease of Trypansoma cruzi, and cathepsins B and L. K777 tosylate is a broad-spectrum antiviral by targeting cathepsin-mediated cell entry. K777 tosylate inhibits SARS-CoV and EBOV pseudovirus entry with IC50 values of 0.68 nM and 0.87 nM, respectively.
