1. Signaling Pathways
  2. GPCR/G Protein
    Neuronal Signaling
  3. Dopamine Receptor
  4. D1 Receptor Isoform
  5. D1 Receptor Antagonist

D1 Receptor Antagonist

D1 Receptor Antagonists (25):

Cat. No. Product Name Effect Purity
  • HY-19545A
    SCH-23390 hydrochloride
    Antagonist 99.91%
    SCH-23390 hydrochloride (R-(+)-SCH-23390 hydrochloride) is a potent and selective dopamine D1-like receptor antagonist with Kis of 0.2 nM and 0.3 nM for the D1 and D5 receptor, respectively.
  • HY-103414
    Raclopride
    Antagonist 99.72%
    Raclopride is a dopamine D2/D3 receptor antagonist with potential antipsychotic effects.
  • HY-103430A
    SKF-83566
    Antagonist 99.86%
    SKF-83566 is a potent, blood-brain permeable and orally active D1-like dopamine receptor (D1DR) antagonist and a weaker competitive antagonist at the vascular 5-HT2 receptor (Ki=11 nM).
  • HY-15856B
    Flupentixol dihydrochloride
    Antagonist 99.73%
    Flupentixol is an orally active D1/D2 dopamine receptor antagonist and new PI3K inhibitor (PI3Kα IC50=127 nM).
  • HY-101313
    (S)-Remoxipride
    Antagonist
    (S)-Remoxipride ((-)-Remoxipride) is a selective dopamine D2-receptor antagonist with an IC50 value of 1.57 μM.
  • HY-B0274
    Chlorprothixene
    Antagonist 99.13%
    Chlorprothixene is a dopamine and histamine receptors antagonist with Kis of 18 nM, 2.96 nM, 4.56 nM, 9 nM and 3.75 nM for hD1, hD2, hD3, hD5 and hH1 receptors, respectively.
  • HY-10121
    Asenapine
    Antagonist 99.93%
    Asenapine (Org 5222), an atypical antipsychotic, is an antagonist of serotonin receptors (pKi: 8.4-10.5), adrenoceptors (pKi: 8.9-9.5), dopamine receptors (pKi: 8.9-9.4) and histamine receptors (pKi: 8.2-9.0).
  • HY-B0274A
    Chlorprothixene hydrochloride
    Antagonist ≥98.0%
    Chlorprothixene hydrochloride is a dopamine and histamine receptors antagonist with Kis of 18 nM, 2.96 nM, 4.56 nM, 9 nM and 3.75 nM for hD1, hD2, hD3, hD5 and hH1 receptors, respectively.
  • HY-13575
    Blonanserin
    Antagonist 98.73%
    Blonanserin (AD-5423) is a potent and orally active 5-HT2A (Ki=0.812 nM) and dopamine D2 receptor (Ki =0.142 nM) antagonist.
  • HY-N0096
    Rotundine
    Antagonist 99.87%
    Rotundine is an antagonist of dopamine D1, D2 and D3 receptors with IC50s of 166 nM, 1.4 μM and 3.3 μM, respectively.
  • HY-B1371A
    Spiperone hydrochloride
    Antagonist 99.10%
    Spiperone hydrochloride (Spiroperidol hydrochloride) is a selective dopamine D2 receptor (Ki values of 0.06 nM, 0.6 nM, 0.08 nM, ~350 nM, ~3500 nM for D2, D3, D4, D1 and D5 receptors, respectively) and 5-HT2A/5-HT1A receptor (Kis of 1 nM/49 nM) antagonist.
  • HY-17410
    Iloperidone
    Antagonist 99.97%
    Iloperidone (HP 873) is a D2/5-HT2 receptor antagonist.
  • HY-100971
    Spiramide
    Antagonist 98.81%
    Spiramide (AMI-193) is a potent and selective antagonist of 5-HT2 and dopamine D2 receptor, with Kis of 2 nM and 3 nM, respectively.
  • HY-110033
    Ecopipam hydrobromide
    Antagonist ≥99.0%
    Ecopipam (SCH 39166) hydrobromide is a potent, selective and orally active antagonist of dopamine D1/D5 receptor, with Kis of 1.2 nM and 2.0 nM, respectively.
  • HY-103430
    SKF-83566 hydrobromide
    Antagonist
    SKF-83566 hydrobromide is a potent, blood-brain permeable and orally active D1-like dopamine receptor (D1DR) antagonist and a weaker competitive antagonist at the vascular 5-HT2 receptor (Ki=11 nM).
  • HY-13575A
    Blonanserin dihydrochloride
    Antagonist
    Blonanserin dihydrochloride is a potent and orally active 5-HT2A and dopamine D2 receptor antagonist, with Ki values of 0.812 and 0.142 nM, respectively.
  • HY-108400
    SCH-23390 maleate
    Antagonist
    SCH-23390 maleate (R-(+)-SCH-23390 maleate) is a potent and selective dopamine D1-like receptor antagonist with Kis of 0.2 nM and 0.3 nM for the D1 and D5 receptor, respectively.
  • HY-108976
    Raclopride tartrate
    Antagonist
    Raclopride tartrate is a selective dopamine D2/D3 receptor antagonist with potential antipsychotic effects.
  • HY-B0731
    Perospirone hydrochloride
    Antagonist
    Perospirone hydrochloride (SM-9018) is an orally active antagonist of 5-HT2A receptor (Ki of 0.6 nM) and dopamine D2 receptor (Ki of 1.4 nM).
  • HY-14690
    Ecopipam
    Antagonist
    Ecopipam (SCH 39166) is a potent, selective and orally active antagonist of dopamine D1/D5 receptor, with Kis of 1.2 nM and 2.0 nM, respectively.