D₁ Receptor Antagonist

D₁ Receptor Antagonists (25):

Cat. No.	Product Name	Effect	Purity

HY-19545A

SCH-23390 hydrochloride	Antagonist	99.91%
SCH-23390 hydrochloride (R-(+)-SCH-23390 hydrochloride) is a potent and selective dopamine D₁-like receptor antagonist with K_is of 0.2 nM and 0.3 nM for the D₁ and D₅ receptor, respectively.

HY-103414

Raclopride	Antagonist	99.72%
Raclopride is a dopamine D₂/D₃ receptor antagonist with potential antipsychotic effects.

HY-103430A

SKF-83566	Antagonist	99.86%
SKF-83566 is a potent, blood-brain permeable and orally active D1-like dopamine receptor (D1DR) antagonist and a weaker competitive antagonist at the vascular 5-HT₂ receptor (K_i=11 nM).

HY-15856B

Flupentixol dihydrochloride	Antagonist	99.73%
Flupentixol is an orally active D₁/D₂ dopamine receptor antagonist and new PI3K inhibitor (PI3Kα IC₅₀=127 nM).

HY-101313

(S)-Remoxipride	Antagonist
(S)-Remoxipride ((-)-Remoxipride) is a selective dopamine D₂-receptor antagonist with an IC₅₀ value of 1.57 μM.

HY-B0274

Chlorprothixene	Antagonist	99.13%
Chlorprothixene is a dopamine and histamine receptors antagonist with K_is of 18 nM, 2.96 nM, 4.56 nM, 9 nM and 3.75 nM for hD1, hD2, hD3, hD5 and hH1 receptors, respectively.

HY-10121

Asenapine	Antagonist	99.93%
Asenapine (Org 5222), an atypical antipsychotic, is an antagonist of serotonin receptors (pK_i: 8.4-10.5), adrenoceptors (pK_i: 8.9-9.5), dopamine receptors (pK_i: 8.9-9.4) and histamine receptors (pK_i: 8.2-9.0).

HY-B0274A

Chlorprothixene hydrochloride	Antagonist	≥98.0%
Chlorprothixene hydrochloride is a dopamine and histamine receptors antagonist with K_is of 18 nM, 2.96 nM, 4.56 nM, 9 nM and 3.75 nM for hD1, hD2, hD3, hD5 and hH1 receptors, respectively.

HY-13575

Blonanserin	Antagonist	98.73%
Blonanserin (AD-5423) is a potent and orally active 5-HT_2A (K_i=0.812 nM) and dopamine D2 receptor (K_i=0.142 nM) antagonist.

HY-N0096

Rotundine	Antagonist	99.87%
Rotundine is an antagonist of dopamine D1, D2 and D3 receptors with IC₅₀s of 166 nM, 1.4 μM and 3.3 μM, respectively.

HY-B1371A

Spiperone hydrochloride	Antagonist	99.10%
Spiperone hydrochloride (Spiroperidol hydrochloride) is a selective dopamine D₂ receptor (K_i values of 0.06 nM, 0.6 nM, 0.08 nM, ~350 nM, ~3500 nM for D₂, D₃, D₄, D₁ and D₅ receptors, respectively) and 5-HT_2A/5-HT_1A receptor (K_is of 1 nM/49 nM) antagonist.

HY-17410

Iloperidone	Antagonist	99.97%
Iloperidone (HP 873) is a D₂/5-HT₂ receptor antagonist.

HY-100971

Spiramide	Antagonist	98.81%
Spiramide (AMI-193) is a potent and selective antagonist of 5-HT₂ and dopamine D2 receptor, with K_is of 2 nM and 3 nM, respectively.

HY-110033

Ecopipam hydrobromide	Antagonist	≥99.0%
Ecopipam (SCH 39166) hydrobromide is a potent, selective and orally active antagonist of dopamine D1/D5 receptor, with K_is of 1.2 nM and 2.0 nM, respectively.

HY-103430

SKF-83566 hydrobromide	Antagonist
SKF-83566 hydrobromide is a potent, blood-brain permeable and orally active D1-like dopamine receptor (D1DR) antagonist and a weaker competitive antagonist at the vascular 5-HT₂ receptor (K_i=11 nM).

HY-13575A

Blonanserin dihydrochloride	Antagonist
Blonanserin dihydrochloride is a potent and orally active 5-HT_2A and dopamine D2 receptor antagonist, with K_i values of 0.812 and 0.142 nM, respectively.

HY-108400

SCH-23390 maleate	Antagonist
SCH-23390 maleate (R-(+)-SCH-23390 maleate) is a potent and selective dopamine D₁-like receptor antagonist with K_is of 0.2 nM and 0.3 nM for the D₁ and D₅ receptor, respectively.

HY-108976

Raclopride tartrate	Antagonist
Raclopride tartrate is a selective dopamine D₂/D₃ receptor antagonist with potential antipsychotic effects.

HY-B0731

Perospirone hydrochloride	Antagonist
Perospirone hydrochloride (SM-9018) is an orally active antagonist of 5-HT_2A receptor (K_i of 0.6 nM) and dopamine D₂ receptor (K_i of 1.4 nM).

HY-14690

Ecopipam	Antagonist
Ecopipam (SCH 39166) is a potent, selective and orally active antagonist of dopamine D1/D5 receptor, with K_is of 1.2 nM and 2.0 nM, respectively.

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