Drug Derivative
Drug derivative
Drug derivatives are derived from parent compounds. They replace or add atoms and groups through chemical reactions to optimize the various properties of the parent compound and reduce side effects. The application of drug derivatives provides a diverse compound library for drug research and development and accelerates the discovery of new drugs. For example, urea derivatives Glibenclamide can prolong the blood sugar-lowering effect of anti-diabetic drugs.
References:
- [1]. Vardanyan RS, et al. Fentanyl-related compounds and derivatives: current status and future prospects for pharmaceutical applications. Future Med Chem. 2014 Mar;6(4):385-412.x
- [2]. Ghosh AK, et al. Urea Derivatives in Modern Drug Discovery and Medicinal Chemistry. J Med Chem. 2020 Mar 26;63(6):2751-2788.x
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Drug Derivative Inhibitors
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Drug Derivative Related Products (4056)
Related Products (4056)
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14,15-EE-8(Z)-E
0 ImagesCat. No.: HY-165067CAS No.: 519038-93-8Synonyms: 14,15-Epoxyeicosa-8(Z)-enoic acid14,15-EE-8(Z)-E (14,15-Epoxyeicosa-8(Z)-enoic acid) has potent vasodilator agonist activity in bovine coronary arteries. 14,15-EE-8(Z)-E is a 14,15-EET (HY-113489) analog. EETs represent important mediators of coronary vascular tone.
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5-MeO-NBpBrT
0 ImagesCat. No.: HY-180495CAS No.: 155639-13-7Synonyms: 5MT-NB4B5-MeO-NBpBrT (Compound 2f) (5MT-NB4B) is a NBOMe derivative and 5MT-based N-(bromobenzyl) isomer.
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2-Methoxy-3-methylcarbazole
0 Images2-Methoxy-3-methylcarbazole is a natural carbazole alkaloid.
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4-Cl-Benzodioxolyl chalcone
0 ImagesCat. No.: HY-181638CAS No.: 934022-22-74-Cl-Benzodioxolyl chalcone is a type of chalcone. It reduces the viability of endometriotic cells while maintaining or increasing the viability of normal endometrial cells. 4-Cl-Benzodioxolyl chalcone can be used in the research of endometriosis.
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4-Hydroxy DPT
0 ImagesCat. No.: HY-118802CAS No.: 63065-88-34-Hydroxy DPT is a tryptamine that induces the head-twitch response (HTR) in mice.
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Besifovir Dipivoxil
0 ImagesCat. No.: HY-113586CAS No.: 441785-26-8Synonyms: LB-80380Besifovir Dipivoxil (LB-80380), an analog of guanosine monophosphate, is an acyclic nucleotide phosphonate with antiviral effect. Besifovir Dipivoxil is rapidly converted by the liver and intestine to the intermediate metabolite LB80331 via the esterification process, subsequently phosphorylated into the di- and triphosphate forms, which act as antiviral DNA synthesis inhibitors. Besifovir Dipivoxil is promising for research of chronic hepatitis B.
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Ambroxdiol
0 ImagesCat. No.: HY-N1409CAS No.: 38419-75-9Ambroxdiol is a diterpenoid compound with anti-inflammatory activity. Ambroxdiol can be used as an active ingredient in the preparation of preparations for inhibiting inflammatory responses, and can also be used as an anti-inflammatory ingredient in cosmetic preparations for skin and mucous membrane care. Ambroxdiol is applicable to the research of inflammatory diseases.
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5-Formyltetrahydropteroic acid hydrochloride
0 ImagesCat. No.: HY-W654199CAS No.: 2469007-14-35-Formyltetrahydropteroic acid hydrochloride is a derivative of Folinic acid (HY-17556).
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N-Benzenesulfonyltryptamine
0 ImagesN-Benzenesulfonyltryptamine is an inhibitor of Hydroxyindole-O-methyltransferase (HIOMT).
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Proxicromil
0 ImagesCat. No.: HY-164012CAS No.: 60400-92-2Proxicromil is a derivative of chromone. Proxicromil is an orally active anti-asthmatic agent, and exhibits no liver toxicity.
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1,2-Bis(phenylsulfinyl)ethanepalladium(II) acetate
0 ImagesSynonyms: White catalyst1,2-Bis(phenylsulfinyl)ethanepalladium(II) acetate (White catalyst) is an active compound.
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Hydroxyacetildenafil
0 ImagesCat. No.: HY-W587964CAS No.: 147676-56-0Hydroxyacetildenafil is an analog of Acetildenafil (HY-13927).
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Acetylaranotin
0 ImagesCat. No.: HY-122474CAS No.: 20485-01-2Acetylaranotin is a metabolite produced by the fungus Arachniotus aureus, exhibiting antitumor activity. Acetylaranotin is utilized in research within the field of oncology for its potential in anti-cancer applications.
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BAS-118
0 ImagesCat. No.: HY-169823CAS No.: 218936-13-1BAS-118 is a benzamide derivative with antibacterial activity. The MIC50, MIC90 and MIC ranges of BAS-118 for 100 randomly selected isolates of Helicobacter pylori are ≤0.003, 0.013 and ≤0.003-0.025 mg/L, respectively. BAS-118 is promising for research of anti-H. pylori agent.
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Lamellarin H
0 ImagesCat. No.: HY-121430CAS No.: 115982-22-4Lamellarin H is a benzo-isoquinoline-coumarin.
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5-PT TFA
0 ImagesCat. No.: HY-156562BCAS No.: 3117303-22-4Synonyms: 5-Propargyltryptamide TFA5-PT (5-Propargyltryptamide) TFA is an alkyne-functionalized derivative of 5-HT (HY-B1473A) and serotonylation substrate that can be taken up by living cells. After conjugation with biotin, 5-PT TFA enables the identification of serotonylated proteins via copper click chemistry and mass spectrometry. 5-PT TFA can label and isolate serotonylated cells in alveolar epithelial cells for proteomic analysis. 5-PT TFA is applicable to research related to bronchopulmonary dysplasia.
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3,4-MDPA hydrochloride
0 ImagesCat. No.: HY-172031CAS No.: 74341-77-83,4-MDPA hydrochloride is a phenethylamine.
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25iP-NBOMe hydrochloride
0 ImagesCat. No.: HY-W720337CAS No.: 2725318-60-325iP-NBOMe hydrochloride is classified as a phenethylamine.
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2-Amino-1-(4-chlorophenyl)propan-1-one hydrochloride
0 ImagesCat. No.: HY-W173408CAS No.: 23184-97-62-Amino-1-(4-chlorophenyl)propan-1-one hydrochloride is a drug derivative.
