2. Signaling Pathways
  3. Metabolic Enzyme/Protease
  4. Drug Metabolite

Drug Metabolite

Drug Metabolite

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Drug metabolite results when a drug is metabolized into a modified form which continues to produce effects. Drug metabolism redox reactions such as heteroatom dealkylations, hydroxylations, heteroatom oxygenations, reductions, and dehydrogenations can yield active metabolites, and in rare cases even conjugation reactions can yield an active metabolite.

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-131396
    α-Hydroxy Montelukast
    α-Hydroxy Montelukast (M7) is a metabolite of Montelukast (HY-13315A).
    α-Hydroxy Montelukast
  • HY-G0011S
    Netupitant N-oxide-d6
    Netupitant N-oxide-d6 is the deuterium labeled Netupitant N-oxide, which is a metabolite of Netupitant.
    Netupitant N-oxide-d<sub>6</sub>
  • HY-171238
    Dihydroechinofuran
    Dihydroechinofuran is an abenzoquinone metabolite.
    Dihydroechinofuran
  • HY-A0111A
    Cefetamet sodium
    Cefetamet (Ro 15-8074) sodium is a cephalosporin antibiotic and the active metabolite of Cefetamet pivoxil (HY-B1894A). Cefetamet sodium binds to bacterial penicillin-binding protein (PBP) (IC50 for PBP3 in Escherichia coli W3110 is 2.5 μg/mL). Cefetamet sodium has significant activity against Gram-negative bacteria such as Enterobacteriaceae, Neisseria species, and Haemophilus influenzae, as well as Gram-positive bacteria such as Streptococcus. Cefetamet sodium kills and lyses Treponema pallidum. Cefetamet sodium can be used in the research of respiratory tract, urinary tract, ear, nose and throat infections, and syphilis.
    Cefetamet sodium
  • HY-149504
    3-Hydroxy darifenacin
    3-Hydroxy darifenacin is a metabolite of Darifenacin (HY-A0033). 3-Hydroxy darifenacin is an antagonist of M1-5 muscarinic receptors with Kis values of 17.78, 79.43, 2.24, 36.31 and 6.17 nM, respectively in CHO cells.
    3-Hydroxy darifenacin
  • HY-W012481R
    Nirvanol (Standard)
    Nirvanol (Ethylphenylhydantoin) is a metabolite of Mephenytoin (HY-B1184) that exerts anticonvulsant effects in the maximal electroshock (M.E.S.) seizure model in mice. Nirvanol shows potential for research in epilepsy-related neurological disorders.
    Nirvanol (Standard)
  • HY-W587489
    RL-603
    RL-603 is the metabolite of Anagrelide (HY-B0523). RL-603 exhibits platelet-lowering activity in mouse model.
    RL-603
  • HY-137070
    Rivaroxaban diol
    Rivaroxaban diol is a metabolite of Rivaroxaban (HY-50903). Rivaroxaban (BAY 59-7939) is a highly potent, selective and direct Factor Xa (FXa) inhibitor, achieving a strong gain in anti-FXa potency (IC50 0.7 nM; Ki 0.4 nM).
    Rivaroxaban diol
  • HY-W753141
    p,p'-DDE-13C12
    p,p'-DDE-13C12 is 13C labeled p,p'-DDE. p,p'-DDE (4,4'-DDE), a major metabolite of persistent dichlorodiphenyltrichloroethane (DDT), is a potent androgen receptor antagonist, with an IC50 of 5 μM and a Ki of 3.5 μM.
    p,p'-DDE-<sup>13</sup>C<sub>12</sub>
  • HY-N15533
    (S)-Menthiafolic acid
    (S)-Menthiafolic acid is a component found in wines and grape juices. (S)-Menthiafolic acid can be generated from the grape-derived (S)-menthiafolic acid glucose ester during alcoholic and malolactic fermentation, thereby influencing the aroma components of wine.
    (S)-Menthiafolic acid
  • HY-169878
    CNJ-294
    CNJ-294 is an intermediate in the synthesis of Capmatinib (HY-13404) and a metabolite of Capmatinib (HY-13404).
    CNJ-294
  • HY-131270R
    Febuxostat impurity 8 (Standard)
    Febuxostat impurity 8 (Standard) is the analytical standard of Febuxostat impurity 8. This product is intended for research and analytical applications. Febuxostat impurity 8 is an impurity of Febuxostat. Febuxostat is selective xanthine oxidase inhibitor with a Ki of 0.6 nM.
    Febuxostat impurity 8 (Standard)
  • HY-W714239
    Spirotetramat-keto-hydroxy
    Spirotetramat-keto-hydroxy is a metabolite of Spirotetramat (HY-120253). Spirotetramat is an insecticide.
    Spirotetramat-keto-hydroxy
  • HY-10873R
    N-Desethyl Sunitinib (Standard)
    N-Desethyl Sunitinib (Standard) is the analytical standard of N-Desethyl Sunitinib. This product is intended for research and analytical applications. N-Desethyl Sunitinib (SU-12662) is a metabolite of sunitinib. Sunitinib is a potent, ATP-competitive VEGFR, PDGFRβ and KIT inhibitor with Ki values of 2, 9, 17, 8 and 4 nM for VEGFR -1, -2, -3, PDGFRβ and KIT, respectively[1].
    N-Desethyl Sunitinib (Standard)
  • HY-W803860
    N-Depropylpropafenone
    N-Depropylpropafenone is an active metabolite of Propafenone (HY-B0432), generated through the CYP450 enzyme system (mainly CYP2D6). It functions by blocking sodium ion channels, slowing myocardial conduction and exhibiting certain antiarrhythmic effects.
    N-Depropylpropafenone
  • HY-W587941
    Fenthion sulfoxide
    Fenthion sulfoxide is a metabolite of the organophosphate insecticide Fenthion. Fenthion sulfoxide can be formed from the transformation of Fenthion on grapes.
    Fenthion sulfoxide
  • HY-W741491
    6-O-Demethyl griseofulvin
    6-O-Demethyl griseofulvin is a metabolite of Griseofulvin (HY-17583).
    6-O-Demethyl griseofulvin
  • HY-137769
    Captopril EP Impurity C
    Captopril EP Impurity C is an impurity of Captopril. Captopril (SQ-14534), antihypertensive agent, is a thiol-containing competitive, orally active angiotensin-converting enzyme (ACE) inhibitor (IC50=0.025 μM).
    Captopril EP Impurity C
  • HY-15661A
    OSI-413 free base
    OSI-413 (free base) (CP 373413) is a major metabolite of Erlotinib (HY-50896). Erlotinib (CP-358774) is a directly acting EGFR tyrosine kinase inhibitor, with an IC50 of 2 nM for human EGFR.
    OSI-413 free base
  • HY-103005R
    Ramelteon metabolite M-II (Standard)
    Amlodipine (maleate) (Standard) is the analytical standard of Amlodipine (maleate). This product is intended for research and analytical applications. Amlodipine maleate is a dihydropyridine calcium channel blocker, acts as an orally active antianginal agent. Amlodipine maleate blocks the voltage-dependent L-type calcium channels, thereby inhibiting the initial influx of calcium. Amlodipine maleate can be used for the research of high blood pressure and cancer.
    Ramelteon metabolite M-II (Standard)
Cat. No. Product Name / Synonyms Application Reactivity