Drug Metabolite
Drug metabolite results when a drug is metabolized into a modified form which continues to produce effects. Drug metabolism redox reactions such as heteroatom dealkylations, hydroxylations, heteroatom oxygenations, reductions, and dehydrogenations can yield active metabolites, and in rare cases even conjugation reactions can yield an active metabolite.
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Drug Metabolite Related Products (1984)
Related Products (1984)
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Antibodies (1)
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Related Compound Screening Libraries (1)
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Desmethyl Erlotinib hydrochloride (Standard)
0 ImagesCat. No.: HY-13256RCAS No.: 183320-51-6Synonyms: OSI-420 (Standard); CP-373420 hydrochloride (Standard)Metoclopramide (hydrochloride hydrate) (Standard) is the analytical standard of Metoclopramide (hydrochloride hydrate). This product is intended for research and analytical applications. Metoclopramide hydrochloride hydrate is a potent antagonist of 5-HT3 and dopamine D2 receptor, with IC50s of 308 nM and 483 nM, respectively. Metoclopramide hydrochloride hydrate can be used for the research of nausea and vomiting, gastro-oesophageal reflux, and gastroparesis.
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α-Hydroxysalmeterol
0 ImagesCat. No.: HY-177997CAS No.: 152405-02-2α-Hydroxysalmeterol is a metabolite that can be formed via cytochrome P450 isoform 3A4-induced hydroxylation of Salmeterol (HY-14302). α-Hydroxysalmeterol is a potentially relevant urine biomarker to include when screening for Salmeterol misuse.
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Tacapenem
0 ImagesCat. No.: HY-138024CAS No.: 193811-33-5Synonyms: R-95867Tacapenem (R-95867), the active metabolite of CS-834, is an antibacterial agent. Tacapenem exhibits a broad antibacterial spectrum, with activity against gram-positive and -negative aerobes and anaerobes. Tacapenem shows potent bactericidal activity against S. aureus and Escherichia coli.
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4(Z),7(Z),10(Z),13(Z),16(Z)-N-(2-Hydroxyethyl)-docosapentaenamide
0 ImagesCat. No.: HY-170697CAS No.: 211817-55-94(Z),7(Z),10(Z),13(Z),16(Z)-N-(2-hydroxyethyl)-Docosapentaenamide is a long-chain ω-6 fatty acid with a hydroxyethylamide group attached at the alpha chain.
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α-Hydroxy etizolam
0 ImagesCat. No.: HY-W705371CAS No.: 64546-10-7α-Hydroxy etizolam is the primary metabolite of Etizolam, possessing nearly identical pharmacological potency and high affinity for benzodiazepine receptors as Etizolam.
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INCB-056868
0 ImagesCat. No.: HY-172233CAS No.: 2252320-89-9INCB-056868 is the metabolite M11 of Epacadostat (HY-15689). INCB-056868 can also serve as a substrate for BCRP. INCB-056868 is promising for research of metabolic diseases.
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AGI-16903
0 ImagesCat. No.: HY-165546CAS No.: 1643852-84-9AGI-16903 is a metabolite of Enasidenib (HY-18690). Enasidenib is an orally available, reversible, and selective inhibitor of mutant IDH2 enzymes, with IC50 values of 100 nM and 400 nM against IDH2R140Q and IDH2R172K, respectively.
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N-Desethyl Sunitinib-d4 TFA
0 ImagesCat. No.: HY-10873S1CAS No.: 2012601-57-7Synonyms: SU-12662-d4 TFA
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4-tert-Amylphenol
0 ImagesCat. No.: HY-W099987CAS No.: 80-46-64-tert-Amylphenol is the hydrolysis product of the mixture of phosphorous acid 2,4-bis (1,1-dimethylpropyl) phenyl ester and phosphorous acid 4-(1,1-dimethylpropyl) phenyl triester.
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Lansoprazole sulfone N-Oxide
0 ImagesCat. No.: HY-Z7659CAS No.: 953787-54-7Lansoprazole sulfone N-Oxide (Comound 3) is the overoxidized by-product found in the synthesis of the proton pump inhibitor Lansoprazole (HY-13662). Lansoprazole sulfone N-Oxide is promising for research of duodenal and gastric ulcers, reflux oesophagitis, and Zollinger–Ellison syndrome.
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Penicillamine (Standard)
0 ImagesPenicillamine (Standard) is the analytical standard of Penicillamine. This product is intended for research and analytical applications. Penicillamine (D-(-)-Penicillamine) is a penicillin metabolic degradation product, can be used as a heavy metal chelator. Penicillamine increases free copper and increases oxidative stress. Penicillamine has effect of seizures through nitric oxide/NMDA pathways. Penicillamine is a potential immune modulator. Penicillamine can be used for the research of Wilson disease, rheumatoid arthritis, and cystinuria.
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2-NP-AMOZ (Standard)
0 ImagesCat. No.: HY-136456RCAS No.: 183193-59-12-NP-AMOZ (Standard) is the analytical standard of 2-NP-AMOZ. This product is intended for research and analytical applications. 2-NP-AMOZ is a 2-nitrophenyl derivative of AMOZ (a metabolite of antibiotic Furaltadone), can be used to detect protein bound AMOZ.
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2',2'‐Difluorodeoxyuridine 5'‐triphosphate
0 ImagesCat. No.: HY-185843CAS No.: 1062136-15-5Synonyms: dFdUTP2',2'-Difluorodeoxyuridine 5'-triphosphate (dFdUTP) is the intracellular phosphorylated metabolite of dFdU (HY-138253), which in turn is the deaminated metabolite of Gemcitabine (HY-17026). 2',2'-Difluorodeoxyuridine 5'-triphosphate incorporates into DNA and RNA, contributing to Gemcitabine-associated cytotoxicity and hepatotoxicity. 2',2'-Difluorodeoxyuridine 5'-triphosphate accumulates in the liver and kidneys of mice, and is detectable in mouse plasma and urine. 2',2'-Difluorodeoxyuridine 5'-triphosphate can be used in the research of breast cancer and non-small cell lung cancer.
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Desmethyltrimipramine
0 ImagesSynonyms: DTRIDesmethyltrimipramine (DTRI) is a metabolite of Trimipramine (HY-B1213A) (a 5-HT receptor antagonist and antidepressant).
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Mebendazole-amine (Standard)
0 ImagesCat. No.: HY-114750RCAS No.: 52329-60-9Mebendazole-amine (Standard) is the analytical standard of Mebendazole-amine. This product is intended for research and analytical applications. Mebendazole-amine is a metabolite of Mebendazole. Mebendazole is a broad-spectrum benzimidazole anti-helminthic agent.
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Deslanoside (Standard)
0 ImagesCat. No.: HY-A0154RCAS No.: 17598-65-1Synonyms: Deacetyllanatoside C (Standard); Desacetyllanatoside C (Standard)Deslanoside (Standard) is the analytical standard of Deslanoside. This product is intended for research and analytical applications. Deslanoside (Desacetyllanatoside C) is a rapidly acting cardiac glycoside used to treat congestive heart failure and supraventricular arrhythmias due to reentry mechanisms, and to control ventricular rate in the treatment of chronic atrial fibrillation. Deslanoside inhibits the Na-K-ATPase membrane pump, resulting in an increase in intracellular sodium and calcium concentrations .
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ETM-305
0 ImagesCat. No.: HY-177966CAS No.: 250159-76-3ETM-305 is a degradation product of the anticancer agent ET-743 (HY-50936). ET-743 (Ecteinascidin 743; Trabectedin) is a tetrahydroisoquinoline alkaloid that binds to the minor groove of DNA, blocks the transcription of stress-induced proteins, induces DNA backbone cleavage and cancer cell apoptosis, and increases ROS production in MCF-7 and MDA-MB-453 cells. Trabectedin is used in the research of soft tissue sarcoma and ovarian cancer.
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3-Hydroxy desalkylgidazepam
0 ImagesCat. No.: HY-171043CAS No.: 37891-18-23-Hydroxy desalkylgidazepam (compound 2) is the active metabolite of Gidazepam (HY-U00315) and Desalkylgidazepam (HY-W634748).
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Bisphenol A bissulfate disodium
0 ImagesCat. No.: HY-W587516CAS No.: 10040-44-5Bisphenol A bissulfate disodium is a metabolite of Bisphenol A (HY-18260). Bisphenol A bissulfate disodium (compound 7) show complement-inhibiting activity with an IC50 of 247 μM.
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3-(Methylphosphinico)propionic acid
0 ImagesCat. No.: HY-W335576CAS No.: 15090-23-03-(Methylphosphinico)propionic acid serves as a metabolite of the pesticide glufosinate ammonium.
