Drug Metabolite
Drug metabolite results when a drug is metabolized into a modified form which continues to produce effects. Drug metabolism redox reactions such as heteroatom dealkylations, hydroxylations, heteroatom oxygenations, reductions, and dehydrogenations can yield active metabolites, and in rare cases even conjugation reactions can yield an active metabolite.
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Drug Metabolite Related Products (1999)
Related Products (1999)
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Antibodies (1)
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Related Compound Screening Libraries (1)
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4-tert-Amylphenol
0 ImagesCat. No.: HY-W099987CAS No.: 80-46-64-tert-Amylphenol is the hydrolysis product of the mixture of phosphorous acid 2,4-bis (1,1-dimethylpropyl) phenyl ester and phosphorous acid 4-(1,1-dimethylpropyl) phenyl triester.
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Lansoprazole sulfone N-Oxide
0 ImagesCat. No.: HY-Z7659CAS No.: 953787-54-7Lansoprazole sulfone N-Oxide (Comound 3) is the overoxidized by-product found in the synthesis of the proton pump inhibitor Lansoprazole (HY-13662). Lansoprazole sulfone N-Oxide is promising for research of duodenal and gastric ulcers, reflux oesophagitis, and Zollinger–Ellison syndrome.
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Penicillamine (Standard)
0 ImagesPenicillamine (Standard) is the analytical standard of Penicillamine. This product is intended for research and analytical applications. Penicillamine (D-(-)-Penicillamine) is a penicillin metabolic degradation product, can be used as a heavy metal chelator. Penicillamine increases free copper and increases oxidative stress. Penicillamine has effect of seizures through nitric oxide/NMDA pathways. Penicillamine is a potential immune modulator. Penicillamine can be used for the research of Wilson disease, rheumatoid arthritis, and cystinuria.
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2-NP-AMOZ (Standard)
0 ImagesCat. No.: HY-136456RCAS No.: 183193-59-12-NP-AMOZ (Standard) is the analytical standard of 2-NP-AMOZ. This product is intended for research and analytical applications. 2-NP-AMOZ is a 2-nitrophenyl derivative of AMOZ (a metabolite of antibiotic Furaltadone), can be used to detect protein bound AMOZ.
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2',2'‐Difluorodeoxyuridine 5'‐triphosphate
0 ImagesCat. No.: HY-185843CAS No.: 1062136-15-5Synonyms: dFdUTP2',2'-Difluorodeoxyuridine 5'-triphosphate (dFdUTP) is the intracellular phosphorylated metabolite of dFdU (HY-138253), which in turn is the deaminated metabolite of Gemcitabine (HY-17026). 2',2'-Difluorodeoxyuridine 5'-triphosphate incorporates into DNA and RNA, contributing to Gemcitabine-associated cytotoxicity and hepatotoxicity. 2',2'-Difluorodeoxyuridine 5'-triphosphate accumulates in the liver and kidneys of mice, and is detectable in mouse plasma and urine. 2',2'-Difluorodeoxyuridine 5'-triphosphate can be used in the research of breast cancer and non-small cell lung cancer.
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Desmethyltrimipramine
0 ImagesSynonyms: DTRIDesmethyltrimipramine (DTRI) is a metabolite of Trimipramine (HY-B1213A) (a 5-HT receptor antagonist and antidepressant).
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Mebendazole-amine (Standard)
0 ImagesCat. No.: HY-114750RCAS No.: 52329-60-9Mebendazole-amine (Standard) is the analytical standard of Mebendazole-amine. This product is intended for research and analytical applications. Mebendazole-amine is a metabolite of Mebendazole. Mebendazole is a broad-spectrum benzimidazole anti-helminthic agent.
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Deslanoside (Standard)
0 ImagesCat. No.: HY-A0154RCAS No.: 17598-65-1Synonyms: Deacetyllanatoside C (Standard); Desacetyllanatoside C (Standard)Deslanoside (Standard) is the analytical standard of Deslanoside. This product is intended for research and analytical applications. Deslanoside (Desacetyllanatoside C) is a rapidly acting cardiac glycoside used to treat congestive heart failure and supraventricular arrhythmias due to reentry mechanisms, and to control ventricular rate in the treatment of chronic atrial fibrillation. Deslanoside inhibits the Na-K-ATPase membrane pump, resulting in an increase in intracellular sodium and calcium concentrations .
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ETM-305
0 ImagesCat. No.: HY-177966CAS No.: 250159-76-3ETM-305 is a degradation product of the anticancer agent ET-743 (HY-50936). ET-743 (Ecteinascidin 743; Trabectedin) is a tetrahydroisoquinoline alkaloid that binds to the minor groove of DNA, blocks the transcription of stress-induced proteins, induces DNA backbone cleavage and cancer cell apoptosis, and increases ROS production in MCF-7 and MDA-MB-453 cells. Trabectedin is used in the research of soft tissue sarcoma and ovarian cancer.
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3-Hydroxy desalkylgidazepam
0 ImagesCat. No.: HY-171043CAS No.: 37891-18-23-Hydroxy desalkylgidazepam (compound 2) is the active metabolite of Gidazepam (HY-U00315) and Desalkylgidazepam (HY-W634748).
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Bisphenol A bissulfate disodium
0 ImagesCat. No.: HY-W587516CAS No.: 10040-44-5Bisphenol A bissulfate disodium is a metabolite of Bisphenol A (HY-18260). Bisphenol A bissulfate disodium (compound 7) show complement-inhibiting activity with an IC50 of 247 μM.
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3-(Methylphosphinico)propionic acid
0 ImagesCat. No.: HY-W335576CAS No.: 15090-23-03-(Methylphosphinico)propionic acid serves as a metabolite of the pesticide glufosinate ammonium.
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N-Acetylprocainamide hydrochloride (Standard)
0 ImagesCat. No.: HY-101433RCAS No.: 34118-92-8Synonyms: Acecainide hydrochloride (Standard); NAPA hydrochloride (Standard)N-Acetylprocainamide (Acecainide) hydrochloride (Standard) is the analytical standard of N-Acetylprocainamide hydrochloride (HY-101433). This product is intended for research and analytical applications. N-Acetylprocainamide hydrochloride is a class III antiarrhythmic, which blocks K+ channels. N-Acetylprocainamide hydrochloride exerts inhibitory effects on the maximum following frequency (MFF) of isolated rabbit atria. N-Acetylprocainamide hydrochloride can be used for the study of arrhythmias.
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Dapagliflozin keto impurity (Standard)
0 ImagesCat. No.: HY-I1198RCAS No.: 2169998-23-4Synonyms: Oxo-dapagliflozin (Standard)Dapagliflozin keto impurity (Standard) (Oxo-dapagliflozin (Standard)) is the analytical standard of Dapagliflozin keto impurity (HY-I1198). This product is intended for research and analytical applications. Dapagliflozin keto impurity (Oxo-dapagliflozin) is an oxo metabolite and related impurity of Dapagliflozin (HY-10450). Dapagliflozin keto impurity can be characterized by 1H NMR, 13C NMR and HRMS, and can be used in studies related to Dapagliflozin impurities and metabolites.
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Morinidazole metabolite-1
0 ImagesCat. No.: HY-128406CAS No.: 1413431-46-5
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Ipriflavone metabolites IV
0 ImagesCat. No.: HY-174298CAS No.: 97846-18-9
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Tolcapone 3-β-D-glucuronide
0 ImagesCat. No.: HY-126194CAS No.: 204853-33-8Synonyms: Ro 61-1448Tolcapone 3-β-D-glucuronide (Ro 61-1448) is an O-methyl metabolite of Tolcapone (HY-17406) and is pharmacologically inactive. Tolcapone (Ro 40-7592) is a selective, potent and orally active COMT inhibitor with an IC50of 773 nM. Tolcapone can inhibits α-syn and Aβ42 oligomerization and fibrillogenesis. Tolcapone can cause oxidative stress and induce cancer cells apoptosis and ROS production. Tolcapone can be used for the researches of cancer and neurological disease, such as Parkinson disease and neuroblastoma.
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Nomelidine
0 ImagesCat. No.: HY-123001CAS No.: 60324-59-6Nomelidine is the metabolite of Zimelidine (HY-118835), that exhibits antidepressant and analgesic properties.
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MMB-ICA
0 ImagesCat. No.: HY-150333CAS No.: 1188516-52-0MMB-ICA is a metabolite of MMB-CHMICA.
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Bupivacaine N-oxide hydrochloride
0 ImagesCat. No.: HY-W585873CAS No.: 1796927-05-3Bupivacaine N-oxide hydrochloride is a metabolite of Bupivacaine (HY-B0405). Bupivacaine is a NMDA receptor inhibitor. Bupivacaine can block sodium, L-calcium, and potassium channels.Bupivacaine potently blocks SCN5A channels with the IC50 of 69.5 μM. Bupivacaine can be used for the research of chronic pain.
