E1/E2/E3 Enzyme
E1 activating enzyme; E2 conjugating enzyme; E3 ligating enzyme; Ubiquitin activating enzyme; Ubiquitin conjugating enzyme; Ubiquitin ligase
Ubiquitin (UB) is a protein modifier that regulates many essential cellular processes. To initiate protein modification by UB, the E1 enzyme activates the C-terminal carboxylate of UB to launch its transfer through the E1-E2-E3 cascade onto target proteins. The E1 enzyme is the activating enzyme, to which ubiquitin is attached in an ATP-dependent reaction by a thioester bond. The E2 enzyme is the conjugating enzyme, to which the ubiquitin is transferred from the E1. The E3 is the ubiquitin ligase, which directly or indirectly catalyzes the transfer of the ubiquitin to the target protein (the substrate), with the formation of an isopeptide bond.
All Product Categories
-
E1/E2/E3 Enzyme Inhibitors
(223)
View all products
-
E1/E2/E3 Enzyme Agonists
(6)
View all products
-
E1/E2/E3 Enzyme Antagonist
(1)
View all products
-
E1/E2/E3 Enzyme Activators
(5)
View all products
-
E1/E2/E3 Enzyme Modulators
(9)
View all products
-
E1/E2/E3 Enzyme Inducer
(1)
View all products
-
E1/E2/E3 Enzyme Degraders
(13)
View all products
-
E1/E2/E3 Enzyme Control
(1)
View all products
-
E1/E2/E3 Enzyme Ligands
(15)
View all products
-
Ubiquitin Enzymes Proteins
(116)
View all products
-
E1/E2/E3 Enzyme Related Products (320)
Related Products (320)
-
Recombinant Proteins (116)
-
Antibodies (88)
-
Related Compound Screening Libraries (1)
-
Keap1-Nrf2-IN-4
0 ImagesCat. No.: HY-144099CAS No.: 2851480-01-6Keap1-Nrf2-IN-4 is a potent neddylation inhibitor. Keap1-Nrf2-IN-4 exhibits potent anti-proliferation activity against MGC-803 cells (IC50=2.55 µM). Keap1-Nrf2-IN-4 blocks the migration ability and induces apoptosis of gastric cancer cells. Keap1-Nrf2-IN-4 inhibits tumor growth without obvious toxicity.
-
Ginkgolic Acid (Standard)
0 ImagesCat. No.: HY-N0077RCAS No.: 22910-60-7Synonyms: Ginkgolic acid (15:1) (Standard); Ginkgolic acid I (Standard); Romanicardic acid (Standard)Ginkgolic Acid (Standard) is the analytical standard of Ginkgolic Acid. This product is intended for research and analytical applications. Ginkgolic Acid is a natural compound that inhibits SUMOylation with an IC50 of 3.0 μM in in vitro assay.
-
Leucettamol A
0 ImagesCat. No.: HY-125660CAS No.: 151124-32-2Leucettamol A is an inhibitor of Ubc13 (ubiquitin E2 enzyme)-Uev1A interaction, with an IC50 of 50 μg/mL. Leucettamol A can potentially activate the expression of cancer suppressor p53 and is a precursor of anticancer agents. Leucettamol A can be isolated from a marine sponge, Leucetta aff. Microrhaphis.
-
CRBN ligand-12
0 ImagesCat. No.: HY-170058CAS No.: 2820501-20-8
-
Hakin-1
0 ImagesCat. No.: HY-176861CAS No.: 346660-34-2Hakin-1 is a E3 Ubiquitin-Ligase Hakai inhibitor. Hakin-1 blocks Hakai-mediated global ubiquitination and specific ubiquitination of E-cadherin and inhibits epithelial-mesenchymal transition (EMT) progression. Hakan-1 inhibits tumor progression and cancer metastasis. Hakin-1 can be used for the study of carcinoma such as colorectal cancer.
-
p62-ZZ ligand 1
0 ImagesCat. No.: HY-168293CAS No.: 2409960-13-8p62-ZZ ligand 1 (Compound 7) is an p62-ZZ ligand. p62-ZZ ligand 1 can be used for synthesis of VinclozolinM2-2204 (HY-161741).
-
Obudanersen
0 ImagesCat. No.: HY-177651CAS No.: 2834724-31-9Synonyms: ION-582Obudanersen is an antisense oligonucleotide targeted to ubiquitin protein ligase E3A-antisense transcript (UBE3A-ATS). It is used for the study of Angelman syndrome.
-
LO-3-62
0 ImagesCat. No.: HY-175186LO-3-62 is a SMARCA2/4 degrader. LO-3-62 incorporates a truncated fumaramide linker and conjugates it to a SMARCA2/4 inhibitor. LO-3-62 binds covalently to the CUL4DCAF16 E3 ubiquitin ligase, inducing proteasome-dependent degradation of SMARCA2/4. LO-3-62 can be used in studies of monocytic leukemia.
-
Pomalidomide-β-D-glucose
0 ImagesCat. No.: HY-189288CAS No.: 2894135-13-6Pomalidomide-β-D-glucose is an orally active Molecular glue degrader of IKZF1 and CK1α. Pomalidomide-β-D-glucose forms a ternary complex with CRBN and substrate proteins, inducing ubiquitination and proteasomal degradation of IKZF1 and CK1α. Pomalidomide-β-D-glucose undergoes GLUT1-mediated cellular uptake. Pomalidomide-β-D-glucose can be used for research on multiple myeloma.
-
MCULE-3064932370
0 ImagesCat. No.: HY-181772CAS No.: 315698-78-3MCULE-3064932370 is a covalent and allosteric SUMO E1 (heterodimer of Aos1 and Uba2) inhibitor with IC50 values ranging from 16.66 μM to 2.96 μM. MCULE-3064932370 inhibits SUMOylation of Uba2. MCULE-3064932370 has anti-cancer activity against breast cancer.
-
Smurf-1-IN-3
0 ImagesCat. No.: HY-157195CAS No.: 1825312-08-0Smurf-1-IN-3 is a selective Smurf-1 inhibitor with an IC50 value of 2.2 nM. Smurf-1-IN-3 can be used for the research of pulmonary arterial hypertension.
-
Cbl-b-IN-31
0 ImagesCat. No.: HY-P11479CAS No.: 3029912-63-5Cbl-b-IN-31 (Compound Pep 1) is a Cbl-b inhibitor with a Kd of 0.42 μM. Cbl-b-IN-31 is inactive in cellular assays. Cbl-b-IN-31 can be used in the research of immune-mediated diseases.
-
Rugonersen sodium scrambled negative control
0 ImagesCat. No.: HY-148130CRugonersen sodium scrambled negative control is the sequence scrambled negative control of Rugonersen sodium.
-
NAMPT activator-9
0 ImagesCat. No.: HY-182062CAS No.: 931366-46-0NAMPT activator-9 (Compound DIPM) is an allosteric, non-competitive NAMPT activator, with an EC50 of 3.366 μM against hNAMPT. NAMPT activator-9 enhances the enzymatic activity of NAMPT via an allosteric, non-competitive mechanism. NAMPT activator-9 increases intracellular NAD+ levels. NAMPT activator-9 restores myotube diameter and reduces the expression of atrophy markers Atrogin-1 and MuRF1. NAMPT activator-9 is applicable to research related to muscle atrophy.
-
DCN1-UBC12-IN-2
0 ImagesCat. No.: HY-142694CAS No.: 2374827-47-9DCN1-UBC12-IN-2 is a potent and specific DCN1-UBC12 inhibitor (IC50=9.55 nM). DCN1-UBC12-IN-2 could specifically target DCN1-UBC12 interaction and relieve Ang II-induced cardiac fibroblast activation.
-
Cbl-b-IN-6
0 ImagesCat. No.: HY-156762CAS No.: 2815221-33-9Cbl-b-IN-6 (Compound 246) is a casitas B-lineage lymphoma-b (Cbl-b) and c-Cbl inhibitor with IC50s of 6.7 nM and 5.2 nM, respectively.
