E1/E2/E3 Enzyme
E1 activating enzyme; E2 conjugating enzyme; E3 ligating enzyme; Ubiquitin activating enzyme; Ubiquitin conjugating enzyme; Ubiquitin ligase
Ubiquitin (UB) is a protein modifier that regulates many essential cellular processes. To initiate protein modification by UB, the E1 enzyme activates the C-terminal carboxylate of UB to launch its transfer through the E1-E2-E3 cascade onto target proteins. The E1 enzyme is the activating enzyme, to which ubiquitin is attached in an ATP-dependent reaction by a thioester bond. The E2 enzyme is the conjugating enzyme, to which the ubiquitin is transferred from the E1. The E3 is the ubiquitin ligase, which directly or indirectly catalyzes the transfer of the ubiquitin to the target protein (the substrate), with the formation of an isopeptide bond.
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E1/E2/E3 Enzyme Inhibitors
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E1/E2/E3 Enzyme Agonists
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E1/E2/E3 Enzyme Antagonist
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E1/E2/E3 Enzyme Activators
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E1/E2/E3 Enzyme Modulators
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E1/E2/E3 Enzyme Inducer
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E1/E2/E3 Enzyme Degraders
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E1/E2/E3 Enzyme Control
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E1/E2/E3 Enzyme Ligands
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Ubiquitin Enzymes Proteins
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E1/E2/E3 Enzyme Related Products (320)
Related Products (320)
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Recombinant Proteins (116)
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Antibodies (88)
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Related Compound Screening Libraries (1)
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Cbl-b-IN-20
0 ImagesCat. No.: HY-158174CAS No.: 3033319-99-9Cbl-b-IN-20 (Example 50) is a casitas proto-oncogene-B ( CPL-B ) inhibitor with IC50 <100 nM.
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DCN1-UBC12-IN-1
0 ImagesCat. No.: HY-142691CAS No.: 2374827-31-1DCN1-UBC12-IN-1 is potent and selective DCN1-UBC12 inhibitor with an IC50 of 2.86 nM. Anticardiac fibrotic effect.
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NSC-217913
0 ImagesCat. No.: HY-168602CAS No.: 79100-27-9NSC-217913 is an inhibitor of WWP1 with an IC50 value of 158.3 μM.
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BRD9 Degrader-3
0 ImagesCat. No.: HY-163810CAS No.: 3033018-77-5BRD9 Degrader-3 is a selective BRD9 BRD9 molecular glue degrader degrader. BRD9 Degrader-3 consists of a BRD9-binding ligand, a linker, and a warhead that promotes proteasomal degradation of BRD9 via a non-canonical PROTAC mechanism independent of CRBN or VHL E3 ligases. BRD9 Degrader-3 can be used in cancer research, including studies of malignant rhabdoid tumors, specific sarcomas, and acute myeloid leukemia.
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Cbl-b-IN-34
0 ImagesCat. No.: HY-184236CAS No.: 2925237-58-5Cbl-b-IN-34 is an orally active and selective Cbl-b inhibitor with a human Kd of 2.4 nM. Cbl-b-IN-34 induces T-cell activation. Cbl-b-IN-34 can be used for the research of colorectal cancer.
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NU-8231
0 ImagesCat. No.: HY-119014CAS No.: 878022-36-7NU-8231 (Compound 2) is a p53-MDM2 binding inhibitor with an IC50 of 5.3-200 μM for inhibiting the p53-MDM2 interaction. NU-8231 is applicable for cancer research.
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EST1140
0 ImagesCat. No.: HY-187458CAS No.: 3105892-11-0EST1140 is a covalent molecular glue degrader targeting RNF126 for AR/AR-V7, with DC50 values of 33 μM and 30 μM, respectively, in 22Rv1 cells. EST1140 covalently binds to the E3 ligase RNF126 to achieve targeted protein degradation. EST1140 can be used in the research of androgen-independent prostate cancer.
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Apazunersen
0 ImagesCat. No.: HY-177615CAS No.: 2919324-01-7Synonyms: GTX-102Apazunersen is an antisense oligonucleotide (ASO) that targets and inhibits expression of the UBE3A antisense transcript (UBE3A-AS) to prevent silencing of the paternally inherited allele of the UBE3A gene and reactivate expression of the deficient protei
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LO-3-61
0 ImagesCat. No.: HY-175179LO-3-61, a JQ-1 (HY-13030) analog bearing a truncated fumaramide handle, is a PROTAC (proteolysis-targeting chimeras)-like BRD4 degrader. LO-3-61 degrades both the long and short isoforms of BRD4 CUL4DcAr16-dependently in cells. LO-3-61 shows selectivity for BRD3 and BRD4 degradation in MDA-MB-231 cells.
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AM-6761
0 ImagesCat. No.: HY-12737CAS No.: 1584732-36-4AM-6761 is a potent MDM2 inhibitor with an IC50 of 0.1 nM.
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GID4-IN-1
0 ImagesCat. No.: HY-163576CAS No.: 3034834-45-9GID4-IN-1 (compd 169) is a GID4 inhibitor with an IC50 <500 nM.
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DCN1-UBC12-IN-3
0 ImagesCat. No.: HY-142692CAS No.: 2374827-45-7DCN1-UBC12-IN-3 is potent and selective DCN1-UBC12 inhibitor with an IC50 of 2.25 nM. Anticardiac fibrotic effect.
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Apazunersen sodium
0 ImagesCat. No.: HY-177615ASynonyms: GTX-102 sodiumApazunersen sodium is an antisense oligonucleotide (ASO) that targets and inhibits expression of the UBE3A antisense transcript (UBE3A-AS) to prevent silencing of the paternally inherited allele of the UBE3A gene and reactivate expression of the deficient
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MurF-IN-1
0 ImagesMurF-IN-1 (Compound 7) is a MurF inhibitor with an pIC50 of 5.19 against S. pneumoniae MurF.
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Apazunersen sodium scrambled negative control
0 ImagesCat. No.: HY-177615BApazunersen sodium scrambled negative control is the sequence scrambled negative control of Apazunersen sodium.
