E1/E2/E3 Enzyme
E1 activating enzyme; E2 conjugating enzyme; E3 ligating enzyme; Ubiquitin activating enzyme; Ubiquitin conjugating enzyme; Ubiquitin ligase
Ubiquitin (UB) is a protein modifier that regulates many essential cellular processes. To initiate protein modification by UB, the E1 enzyme activates the C-terminal carboxylate of UB to launch its transfer through the E1-E2-E3 cascade onto target proteins. The E1 enzyme is the activating enzyme, to which ubiquitin is attached in an ATP-dependent reaction by a thioester bond. The E2 enzyme is the conjugating enzyme, to which the ubiquitin is transferred from the E1. The E3 is the ubiquitin ligase, which directly or indirectly catalyzes the transfer of the ubiquitin to the target protein (the substrate), with the formation of an isopeptide bond.
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E1/E2/E3 Enzyme Inhibitors
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E1/E2/E3 Enzyme Agonists
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E1/E2/E3 Enzyme Antagonist
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E1/E2/E3 Enzyme Activators
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E1/E2/E3 Enzyme Modulators
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E1/E2/E3 Enzyme Inducer
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E1/E2/E3 Enzyme Degraders
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E1/E2/E3 Enzyme Control
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E1/E2/E3 Enzyme Ligands
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Ubiquitin Enzymes Proteins
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E1/E2/E3 Enzyme Related Products (319)
Related Products (319)
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Recombinant Proteins (116)
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Antibodies (88)
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Related Compound Screening Libraries (1)
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HLI98C
0 ImagesCat. No.: HY-18327CAS No.: 317326-90-2HLI98C is a ubiquitin ligase inhibitor. HLI98C inhibits p53 ubiquitylation. HLI98C inhibits HDM2 auto-ubiquitylation.
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Alrizomadlin (Standard)
0 ImagesCat. No.: HY-101518RCAS No.: 1818393-16-6Synonyms: APG-115 (Standard); AA-115 (Standard)Alrizomadlin (Standard) is the analytical standard of Alrizomadlin (HY-101518). This product is intended for research and analytical applications. Alrizomadlin (APG-115) is an orally active MDM2 protein inhibitor binding to MDM2 protein with IC50 and Ki values of 3.8 nM and 1 nM, respectively. Alrizomadlin blocks the interaction of MDM2 and p53 and induces cell-cycle arrest and apoptosis in a p53-dependent manner.
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RG7112 (Standard)
0 ImagesCat. No.: HY-10959RCAS No.: 939981-39-2Synonyms: RO5045337 (Standard)
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Nutlin-3 (Standard)
0 ImagesNutlin-3 (Standard) is the analytical standard of Nutlin-3. This product is intended for research and analytical applications. Nutlin-3 is a commercial available p53-MDM2 inhibitor, with Ki of 90 nM.
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NAcM-OPT (Standard)
0 ImagesCat. No.: HY-111505RCAS No.: 2089293-61-6
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Hinokiflavone (Standard)
0 ImagesCat. No.: HY-N2360RCAS No.: 19202-36-9Hinokiflavone is a novel modulator of pre-mRNA splicing activity extracted from plants with anti-inflammatory, anti-tumor and antiviral activities. Hinokiflavone is also a potent inhibitor for matrix metalloproteinases (MMPs). Hinokiflavone attenuates the virulence of Methicillin (HY-121544)-resistant staphylococcus aureus by inhibiting caseinolytic protease P (ClpP) with an IC50 value of 34.36 mg/mL. Hinokiflavone induces apoptosis via the reactive oxygen species-mitochondria-mediated apoptotic pathway and inhibits tumor cell migration and invasion. Hinokiflavone is a SUMO protease inhibitor against sentrin-specific protease 1 (SENP1) activity.
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NX-1607 (GMP)
0 ImagesCat. No.: HY-141432GCAS No.: 2573775-59-2Synonyms: Cbl-b-IN-3 (GMP)
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SMER3 (Standard)
0 ImagesCat. No.: HY-10949RCAS No.: 67200-34-4SMER3 (Standard) is the analytical standard of SMER3 (HY-10949). This product is intended for research and analytical applications. SMER3, a Rapamycin enhancer, is a selective Skp1-Cullin-F-box (SCF)Met30 ubiquitin ligase inhibitor. SMER3 enhances Rapamycin's growth inhibitory effect by inhibition of SCFMet30.
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Idasanutlin (Standard)
0 ImagesSynonyms: RG7388 (Standard)Idasanutlin (Standard) (RG7388 (Standard)) is the analytical standard of Idasanutlin (HY-15676). This product is intended for research and analytical applications. Idasanutlin (RG7388) is an orally bioavailable MDM2 inhibitor with an IC50 of 6 nM. Idasanutlin disrupts MDM2-p53 binding, stabilizes and activates p53, triggering cell cycle arrest, apoptosis, and reduced cancer cell viability. Idasanutlin reduces EGFR protein expression and phosphorylation, suppresses downstream SHP2, MEK1/2, ERK1/2, AKT, mTOR, p70(S6K1), and S6 signaling. Idasanutlin induces mitochondrial ROS production, drives p38 MAPK phosphorylation, upregulates NOXA, and mediates caspase-3-dependent apoptosis and gasdermin E-mediated pyroptosis. Idasanutlin can be used for the research of TP53-mutant non-small cell lung cancer, T-cell acute lymphoblastic leukemia, colorectal carcinoma, melanoma, diffuse large B-cell lymphoma, mantle cell lymphoma, non-Hodgkin lymphoma, severe fever with thrombocytopenia syndrome, neuroblastoma, acute lymphoblastic leukemia, relapsed or refractory acute myeloid leukemia, osteosarcoma, solid tumors, and hematological tumors.
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VHL Ligand 38
0 ImagesCat. No.: HY-122570CAS No.: 1360616-29-0VHL Ligand 38 (Compound 1) is a competitive E3 ubiquitin-protein ligase VHL inhibitor with IC50s of 4.1 and 7.0 μM in 1% and 10% DMSO, respectively. VHL Ligand 38 contains a hydroxyproline residue and an isoxazolylacetamide fragment. VHL Ligand 38 significantly inhibits the binding of a fluorescent peptide derived from HIF1α (FAM-DEALA-Hyp-YIPD) (HY-P5908F) to VHL.
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Erioflorin
0 ImagesCat. No.: HY-187654CAS No.: 27542-17-2Erioflorin is a sesquiterpene lactone compound originally isolated from plants of the Asteraceae family (such as Eriophyllum confertiflorum and species of the Podanthus genus). Erioflorin acts as a selective β-TrCP1 modulator. Erioflorin induces cell apoptosis by increasing intracellular reactive oxygen species (ROS) production and decreasing mitochondrial membrane potential, inhibits the NF-κB signaling pathway by blocking the phosphorylation of IκBα, and prevents the ubiquitination and degradation of the tumor suppressor Pdcd4 by inhibiting the interaction between Pdcd4 and the E3 ubiquitin ligase β-TrCP1. Erioflorin can be used in research related to breast cancer, colon cancer, advanced prostate cancer, and Chagas disease.
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N106 (Standard)
0 ImagesCat. No.: HY-110273RCAS No.: 862974-25-2N106 (Standard) is the analytical standard of N106 (HY-110273). This product is intended for research and analytical applications. N106 is a first-in-class sarcoplasmic reticulum calcium ATPase (SERCA2a) SUMOylation activator. N106 directly activates the SUMO-activating enzyme, E1 ligase. N106 can be used for heart failure research.
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Subasumstat (Standard)
0 ImagesCat. No.: HY-111789RCAS No.: 1858276-04-6Synonyms: TAK-981 (Standard)Subasumstat (Standard) is the analytical standard of Subasumstat (HY-111789). This product is intended for research and analytical applications. Subasumstat (TAK-981) is a first in class and selective inhibitor of the SUMOylation enzymatic cascade, with potential immune-activating and antineoplastic activities.
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SZL P1-41 (Standard)
0 ImagesCat. No.: HY-100237RCAS No.: 222716-34-9SZL P1-41 (Standard) is the analytical standard of SZL P1-41 (HY-100237). This product is intended for research and analytical applications. SZL P1-41 is a specific Skp2 inhibitor, binds to the F-box domain of Skp2 to prevent Skp1 association and Skp2 SCF complex formation. SZL P1-41, like Skp2 deficiency, augments p27-mediated apoptosis/senescence, while it impairs Akt-driven glycolysis. Anti-tumor activities.
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Teslexivir hydrochloride (Standard)
0 ImagesCat. No.: HY-109045ARCAS No.: 1075281-70-7Synonyms: BTA074 hydrochloride (Standard); AP 611074 hydrochloride (Standard)Teslexivir hydrochloride (Standard) is the analytical standard of Teslexivir (hydrochloride) (HY-109045A). This product is intended for research and analytical applications. Teslexivir (BTA074) hydrochloride is a potent antiviral agent. Teslexivir hydrochloride is a potent and selective inhibitor of the interaction between two essential viral proteins, E1 and E2, an association that is a necessary step in the DNA replication and thus viral production for Human Papilloma Virus (HPV) 6 and 11. Teslexivir hydrochloride can be used for condyloma research.
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MX69 (Standard)
0 ImagesCat. No.: HY-100892RCAS No.: 1005264-47-0
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Nutlin-3a (Standard)
0 ImagesCat. No.: HY-10029RCAS No.: 675576-98-4Synonyms: Rebemadlin (Standard)Nutlin-3a (Standard) is the analytical standard of Nutlin-3a (HY-10029). This product is intended for research and analytical applications. Nutlin-3a (Rebemadlin), an active enantiomer of Nutlin-3, is a potent murine double minute (MDM2) inhibitor (IC50=90 nM). Nutlin-3a inhibits MDM2-p53 interactions and stabilizes the p53 protein, and induces cell autophagy and apoptosis. Nutlin-3a has the potential for the study of TP53 wild-type ovarian carcinomas.
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p53 and MDM2 proteins-interaction-inhibitor (racemic)
0 ImagesCat. No.: HY-70028CAS No.: 939983-14-9
