Idasanutlin (Standard)
Idasanutlin (Standard) (RG7388 (Standard)) is the analytical standard of Idasanutlin (HY-15676). This product is intended for research and analytical applications. Idasanutlin (RG7388) is an orally bioavailable MDM2 inhibitor with an IC50 of 6 nM. Idasanutlin disrupts MDM2-p53 binding, stabilizes and activates p53, triggering cell cycle arrest, apoptosis, and reduced cancer cell viability. Idasanutlin reduces EGFR protein expression and phosphorylation, suppresses downstream SHP2, MEK1/2, ERK1/2, AKT, mTOR, p70(S6K1), and S6 signaling. Idasanutlin induces mitochondrial ROS production, drives p38 MAPK phosphorylation, upregulates NOXA, and mediates caspase-3-dependent apoptosis and gasdermin E-mediated pyroptosis. Idasanutlin can be used for the research of TP53-mutant non-small cell lung cancer, T-cell acute lymphoblastic leukemia, colorectal carcinoma, melanoma, diffuse large B-cell lymphoma, mantle cell lymphoma, non-Hodgkin lymphoma, severe fever with thrombocytopenia syndrome, neuroblastoma, acute lymphoblastic leukemia, relapsed or refractory acute myeloid leukemia, osteosarcoma, solid tumors, and hematological tumors.
For research use only. We do not sell to patients.
- Purity : 98%
- CAS No.: 1229705-06-9
- Formula: C31H29Cl2F2N3O4
- Molecular Weight:616.48
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Product Information
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Chemical Information
- Purity & Documentation
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Help & FAQs
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Product Information
Information
Application
The compound is the grade of analytical standard, which is the reference standard supplied assay. It is commonly used in qualitative, quantitative and methodological research experiments in HPLC, GC and MS.
Chemical Information
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CAS No. 1229705-06-9
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Molecular Weight 616.48
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Formula C31H29Cl2F2N3O4
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SMILES
O=C(O)C1=CC(OC)=C(NC([C@H]2[C@H](C3=C(F)C(Cl)=CC=C3)[C@](C4=CC=C(Cl)C=C4F)(C#N)[C@H](CC(C)(C)C)N2)=O)C=C1
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Synonyms
RG7388 (Standard)
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Idasanutlin (Standard) Related Classifications
HY-15676R Related Classifications
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Keywords
- Idasanutlin (Standard)
- 1229705-06-9
- RG7388 (Standard)
- Reference Standards
- MDM-2/p53
- E1/E2/E3 Enzyme
- Apoptosis
- Pyroptosis
- Reactive Oxygen Species (ROS)
- Caspase
- E1 activating enzyme
- E2 conjugating enzyme
- E3 ligating enzyme
- Ubiquitin activating enzyme
- Ubiquitin conjugating enzyme
- Ubiquitin ligase
- non-small cell lung cancer
- diffuse large B-cell lymphoma
- severe fever with thrombocytopenia syndrome virus
- neuroblastoma
- acute myeloid leukemia
- MDM2
- T-cell acute lymphoblastic leukemia
- p53
- colorectal carcinoma
- melanoma
- Inhibitor
- inhibitor
- inhibit