LO-3-62
LO-3-62 is a SMARCA2/4 degrader. LO-3-62 incorporates a truncated fumaramide linker and conjugates it to a SMARCA2/4 inhibitor. LO-3-62 binds covalently to the CUL4DCAF16 E3 ubiquitin ligase, inducing proteasome-dependent degradation of SMARCA2/4. LO-3-62 can be used in studies of monocytic leukemia.
(Pink: SMARCA2 and SMARCA4 ligand (HY-44012); Blue: CUL4DCAF16 E3 ligase ligand; Black: linker).
For research use only. We do not sell to patients.
- Formula: C23H22ClN7O3
- Molecular Weight:479.92
-
Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
- Purity & Documentation
- References
-
Help & FAQs
Biological Activity
Description
IC50 & Target
[1]|
SMARCA2 |
SMARCA4 |
CUL4DCAF16 |
In Vitro
LO-3-62 (1-10 μM; 24 h) degrades SMARCA2 and SMARCA4 in MV-4-11 cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Cell Line:MV-4-11 cells
-
Concentration:1, 10 μM
-
Incubation Time:24 h
-
Result:Degraded SMARCA2/4 in MV-4-11 cells.
Chemical Information
-
Molecular Weight 479.92
-
Formula C23H22ClN7O3
-
SMILES
O=C(NC1=CC(Cl)=CN=C1)/C=C/C(N2CCN(C3=CC(C4=CC=CC=C4O)=NN=C3N)CC2)=O
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
LO-3-62 Related Classifications
HY-175186 Related Classifications
Powered by Bioz