Glycosidase

Related Products

Glycosidase are a class of enzymes which catalyze the hydrolysis of glycosidic bonds. In living organisms, Glycosidase are involved in carbohydrate metabolism. They can degrade polysaccharides such as starch and glycogen into monosaccharides, providing energy for cells. Glycosidase also participate in the synthesis and modification of biological macromolecules such as glycoproteins and glycolipids, playing a crucial role in cell recognition and signal transduction. Additionally, in plants and microorganisms, Glycosidase are involved in the metabolism of cell wall polysaccharide components, affecting cell growth, differentiation, and morphogenesis. Gene mutations of Glycosidase can trigger genetic diseases, leading to abnormal metabolism in the body and damage to organ functions. Changes in their activity are associated with various diseases such as diabetes, infectious diseases, and tumors, and can influence the occurrence and development of diseases^[1]^[2].

References:

[1]. Wang X, et al. Metabolites extracted from microorganisms as potential inhibitors of glycosidases (α-glucosidase and α-amylase): A review. Front Microbiol. 2022 Nov 17;13:1050869.

[2]. Ohtsubo K, et al. Glycosylation in cellular mechanisms of health and disease. Cell. 2006 Sep 8;126(5):855-67. [Content Brief]

Glycosidase Related Products (605)
Antibodies (3)

By Effects:	Inhibitors (419) Degraders (2) Controls (4) Substrates (18) Ligands (3) Antagonist (1) Activators (18) Modulators (7) Chemical (1) Inducers (2)

Cat. No.	Product Name	Effect	Purity	Chemical Structure

HY-118434

3,4-Methylenedioxychalcone	Inhibitor
3,4-Methylenedioxychalcone (Compound 40) is an α-glucosidase inhibitor with an IC₅₀ of 1870 μM. 3,4-Methylenedioxychalcone is applicable to the research of type 2 diabetes.

HY-N15602

Isosojagol	Inhibitor
Isosojagol (Compound 5) is a α-Glucosidase inhibitor with an IC₅₀ of 32.2  μM. Isosojagol can be isolated from the Roots of Dolichos trilobus. Isosojagol has anti-inflammatory activity and inhibits LPS (HY-D1056A1)-induced NO production in RAW264.7 cells. Isosojagol can be used for fracture, soft tissue injuries and rheumatoid arthritis research.

HY-N10606

Uvagrandol	Inhibitor
Uvagrandol potently inhibits α-glucosidase and porcine lipase (IC₅₀: 15.2 μM, 11.2 μM respectively). Uvagrandol can be used in the research of Type 2 diabetes and obesity.

HY-P2950L

α1-2,3 Mannosidase, Xanthomonas manihotis
α1-2,3 Mannosidase, Xanthomonas manihotis is an acid hydrolase which is located in plant vacuoles and is thought to be involved with the turnover of N-linked glycoproteins.

HY-146156

α-Glucosidase-IN-7	Inhibitor
α-Glucosidase-IN-7 is a noncompetitive α-glucosidase inhibitor with an IC₅₀ value of 18.9 µM.

HY-P2802B

α-Glucosidase, rice
α-Glucosidase, rice is a GH31 glycoside hydrolase in rice seeds, with high selectivity for α-1,4-glycosidic bonds. α-Glucosidase, rice can be inhibited by rice husk extracts (IC₅₀ = 1.25 μg/mL) and steroidal components (IC₅₀ = 1.83 μg/mL). α-Glucosidase, rice exists in two major isoforms, among which isoform II is more sensitive to inhibitors. α-Glucosidase, rice can directly bind to and degrade starch granules in rice seeds. α-Glucosidase, rice can form ONG2-I and ONG2-II via post-translational proteolysis. α-Glucosidase, rice can be used in type 2 diabetes research.

HY-149557

α-Amylase/α-Glucosidase-IN-5	Inhibitor
α-Amylase/α-Glucosidase-IN-5 (compound 4l) is a dual inhibitor of α-glucosidase (Glucosidase) and α-amylase (Amylases) with IC₅₀s of 5.96 μM and 1.62 μM, respectively. α-Amylase/α-Glucosidase-IN-4 has potential antidiabetic activity.

HY-E71305H

β-Glucosidase 1A, Saccharophagus degradans
β-Glucosidase 1A, Saccharophagus degradans (EC 3.2.1.21) is a glucosidase enzyme that acts upon β1->4 bonds linking two glucose or glucose-substituted molecules (i.e., the disaccharide cellobiose) . β-Glucosidase is one of the cellulases, enzymes involved in the decomposition of cellulose and related polysaccharides; more specifically, an exocellulase with specificity for a variety of beta-D-glycoside substrates. It catalyzes the hydrolysis of terminal non-reducing residues in beta-D-glucosides with release of glucose.

HY-147823

α-Glucosidase-IN-6	Inhibitor
α-Glucosidase-IN-6 (compound 18) is a competitive α-glucosidase inhibitor with an IC₅₀ of 5.69 µM. α-Glucosidase-IN-6 has anti-diabetic potential.

HY-170588

α-Glucosidase-IN-78	Inhibitor
α-Glucosidase-IN-78 (Compound 12m) is an inhibitor for α-glucosidase with a reversible, competitive IC₅₀ 6.0 μM. α-Glucosidase-IN-78 can be used in research of diabete for its hypoglycemic property.

HY-N12138

Flaccidoside III	Inhibitor
Flaccidoside III is a triterpenoid isolated from the aerial parts of N. sativa (Ranunculaceae). Flaccidoside III inhibits α-Glucosidase (IC₅₀: 256.7 μM) and has potential antioxidant and antidiabetic activities.

HY-161355

α-Amylase/α-Glucosidase-IN-9	Inhibitor
α-Amylase/α-Glucosidase-IN-9 (compound 5h) is a dual inhibitor for both α-amylase (IC₅₀ = 16.4 μM) and α-glucosidase (IC₅₀ = 31.6 μM) enzymes.

HY-N12688

2,3-Dihydrocalodenin B	Inhibitor
2,3-Dihydrocalodenin B (Compound 6) is a compound that can be isolated from Knema globularia. 2,3-Dihydrocalodenin B is a potent and non-competitive inhibitor against α-glucosidase and α-amylase, with IC₅₀ values of 1.1 and 2.6 μM, respectively. 2,3-Dihydrocalodenin B can be used for the research of diabetes.

HY-169737

Inulobiose	Inhibitor
Inulobiose is a difructan disaccharide that can be isolated from Pistacia vera L.. Inulobiose inhibits α-glycosidase and α-amylase activities with IC₅₀s of 1.87 and 40.72 mg/mL, respectively. Inulobiose can be used for the research of diabetes and glomerular filtration rate testing.

HY-N10440

3-Oxo-hop-22(29)-ene	Inhibitor
3-Oxo-hop-22(29)-ene is a yeast α-glucosidase inhibitor. 3-Oxo-hop-22(29)-ene shows a moderate effect on the viability of T. cruzi and L. mexicana. 3-Oxo-hop-22(29)-ene shows marginal activity of anti-inflammatory.

HY-170866

α-Glucosidase-IN-81	Inhibitor
α-Glucosidase-IN-81 (Compound 5) is a potent α-Glucosidase inhibitor with an IC₅₀ value of 5.30 μM. α-Glucosidase-IN-81 is promising for research of diabetes.

HY-146305

α-Glucosidase-IN-4	Inhibitor	99.05%
α-Glucosidase-IN-4 is a reversible and mixed type α-glucosidase inhibitor with an IC₅₀ of 12.98 μM, a K_I of 27.02 μM, and a K_IS of 13.65 μM, respectively.

HY-N9846

Luteolin 5,3'-dimethyl ether
Luteolin 5,3'-dimethyl ether is a flavonoid compound that exhibits strong binding to enzymes such as acetylcholinesterase (AChE), butyrylcholinesterase (BChE), and α-Glycosidase. Luteolin 5,3'-dimethyl ether can be naturally extracted from the dried roots of Alhagi maurorum (camel thorn). The methanol extract of this plant has significant free radical scavenging ability and enzyme inhibitory potential. Luteolin 5,3'-dimethyl ether can be used in research related to neurodegenerative diseases, diabetes, and skin pigmentation-related diseases.

HY-172622

α-Amylase/α-Glucosidase-IN-19	Inhibitor
α-Amylase/α-Glucosidase-IN-19 (compound 10) is a dual inhibitor of α-amylase /α-glucosidase (IC₅₀= 170.7 μM and 60.37 μM, respectively).

HY-161522

α-Glucosidase-IN-63	Inhibitor
α-Glucosidase-IN-63 (Compound 4d) is an inhibitor of α-Glucosidase (IC₅₀=0.44 μM). α-Glucosidase-IN-63 inhibits hCA II with an activity of K_i= 7.0 nM. α-Glucosidase-IN-63 is orally effective..

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Glycosidase

Glycosidase

Glycosidase Related Products (605)

Antibodies (3)

Glycosidase Related Products (605):